Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Linda C. Johansson"'
Autor:
Nilkanth Patel, Xi Ping Huang, Jessica M Grandner, Linda C Johansson, Benjamin Stauch, John D McCorvy, Yongfeng Liu, Bryan Roth, Vsevolod Katritch
Publikováno v:
eLife, Vol 9 (2020)
Melatonin receptors MT1 and MT2 are involved in synchronizing circadian rhythms and are important targets for treating sleep and mood disorders, type-2 diabetes and cancer. Here, we performed large scale structure-based virtual screening for new liga
Externí odkaz:
https://doaj.org/article/ae3b26d29f104825bba96ae407a6e98e
Autor:
Uwe Weierstall, Reid H.J. Olsen, Raymond C. Stevens, Samuel T. Slocum, Vadim Cherezov, Sahba Zaare, Cornelius Gati, Alexandra R. Tribo, Benjamin Stauch, Chufeng Li, Lan Zhu, Xi Ping Huang, Linda C. Johansson, Gye Won Han, Nadia A. Zatsepin, Saïd Yous, Shuming Hao, Wei Liu, Alexander Batyuk, Bryan L. Roth, John D. McCorvy, Vsevolod Katritch, Jessica M. Grandner, Nilkanth Patel
Publikováno v:
Nature
The human MT1 and MT2 melatonin receptors1,2 are G-protein-coupled receptors (GPCRs) that help to regulate circadian rhythm and sleep patterns3. Drug development efforts have targeted both receptors for the treatment of insomnia, circadian rhythm and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8004f22b43d62595f6b21dd5e7d9bf46
https://doi.org/10.1038/s41586-019-1144-0
https://doi.org/10.1038/s41586-019-1144-0
Autor:
Saïd Yous, Wei Liu, Uwe Weierstall, Raymond C. Stevens, Reid H.J. Olsen, Nairie Michaelian, Alexandra R. Tribo, Anna Shiriaeva, Nilkanth Patel, Vadim Cherezov, Xi Ping Huang, Benjamin Stauch, Gye Won Han, Linda C. Johansson, Bryan L. Roth, Cornelius Gati, Vsevolod Katritch, Alexander Batyuk, Caleb Madsen, Samuel T. Slocum, Thomas D. Grant, Jessica M. Grandner, Andrii Ishchenko, W. Brehm, Lan Zhu, John D. McCorvy, Thomas A. White
Publikováno v:
Nature
Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that maintains circadian rhythms1 by synchronization to environmental cues and is involved in diverse physiological processes2 such as the regulation of blood pressure and core body temperatu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01db116d89c6d5f70d3b37fd9574f72e
http://europepmc.org/articles/PMC6696938
http://europepmc.org/articles/PMC6696938
Autor:
Rebecka Andersson, Gisela Brändén, Gergely Katona, Michał Maj, Antoine Royant, David Arnlund, Hoi Ling Luk, Oleksandr Yefanov, Despina Milathianaki, Sergio Carbajo, Robert Bosman, Greger Hammarin, Linda C. Johansson, Adams Vallejos, Elin Claesson, Joseph Robinson, Cecilia Wickstrand, Erik Malmerberg, Cecilia Safari, Garth J. Williams, Chelsie E. Conrad, Kenneth R. Beyerlein, Richard Neutze, Anton Barty, Chufeng Li, Rajiv Harimoorthy, Daniel P. DePonte, Amit Sharma, Mark S. Hunter, Sébastien Boutet, Viktor Ahlberg Gagnér, Garrett Nelson, Dmitry Morozov, Stella Lisova, Jan Davidsson, Joachim Kübel, Petra Båth, Robert Dods, Mengning Liang, Sebastian Westenhoff, Peter Dahl, Peter Berntsen, Gerrit Groenhof
Publikováno v:
Nature
Nature, Nature Publishing Group, 2021, 589, pp.310-314
Nature / Physical science 589, 310-314 (2021). doi:10.1038/s41586-020-3000-7
Nature, 2021, 589, pp.310-314
Nature, Nature Publishing Group, 2021, 589, pp.310-314
Nature
Nature, 2021, 589, pp.310-314
Nature / Physical science 589, 310 - 314 (2021). doi:10.1038/s41586-020-3000-7
Photosynthetic reaction centres harvest the energy content of sunlight by transporting electrons across an energy-transducing biological membrane. Here we use time-re
Photosynthetic reaction centres harvest the energy content of sunlight by transporting electrons across an energy-transducing biological membrane. Here we use time-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b7a63a423931b71f0eaa238288174c
https://hal.archives-ouvertes.fr/hal-03046608/document
https://hal.archives-ouvertes.fr/hal-03046608/document
Autor:
Benjamin Stauch, Bryan L. Roth, Nilkanth Patel, Yongfeng Liu, Jessica M. Grandner, John D. McCorvy, Linda C. Johansson, Xi Ping Huang, Vsevolod Katritch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f43f52d4d9bb89e03b7d8cadb93bea7
https://doi.org/10.7554/elife.53779.sa2
https://doi.org/10.7554/elife.53779.sa2
Autor:
Richard Neutze, Gergely Katona, Linda C. Johansson, Weixiao Yuan Wahlgren, Amit Sharma, Elin Dunevall
Publikováno v:
Acta Crystallographica. Section A, Foundations and Advances
'Acta Crystallographica A ', vol: 73, pages: 93-101 (2017)
'Acta Crystallographica A ', vol: 73, pages: 93-101 (2017)
Distribution analysis of intensity observations in serial femtosecond crystallography data processing helps to separate Bragg reflections from the background detector response.
Serial crystallography is an increasingly important approach to prot
Serial crystallography is an increasingly important approach to prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392f308d3e0c5f5fc7b2747ffe46b31e
http://europepmc.org/articles/PMC5332129
http://europepmc.org/articles/PMC5332129
Autor:
Nilkanth Patel, Jessica M. Grandner, Xi Ping Huang, John D. McCorvy, Linda C. Johansson, Vsevolod Katritch, Yongfeng Liu, Benjamin Stauch, Bryan L. Roth
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Melatonin receptors MT1 and MT2 are involved in synchronizing circadian rhythms and are important targets for treating sleep and mood disorders, type-2 diabetes and cancer. Here, we performed large scale structure-based virtual screening for new liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba83c522d3fc4fd2781348f52e9b847d
https://pubmed.ncbi.nlm.nih.gov/32118583
https://pubmed.ncbi.nlm.nih.gov/32118583
Autor:
Hye Jin Kang, Terry P. Kenakin, Vadim Cherezov, Anthony Jones, Brian K. Shoichet, Linda C. Johansson, Reed M. Stein, John D. McCorvy, Benjamin Stauch, Bryan L. Roth, Samuel T. Slocum, Xi Ping Huang, Margarita L. Dubocovich, Grant C. Glatfelter, Yurii S. Moroz, John J. Irwin, Tao Che, Olena Savych
Publikováno v:
Nature. 579(7800)
The neuromodulator melatonin synchronizes circadian rhythms and related physiological functions through the actions of two G-protein-coupled receptors: MT1 and MT2. Circadian release of melatonin at night from the pineal gland activates melatonin rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3fbf730c7804af55ae6f97262b16f0b
https://pubmed.ncbi.nlm.nih.gov/32340753
https://pubmed.ncbi.nlm.nih.gov/32340753
Autor:
Benjamin, Stauch, Linda C, Johansson, John D, McCorvy, Nilkanth, Patel, Gye Won, Han, Xi-Ping, Huang, Cornelius, Gati, Alexander, Batyuk, Samuel T, Slocum, Andrii, Ishchenko, Wolfgang, Brehm, Thomas A, White, Nairie, Michaelian, Caleb, Madsen, Lan, Zhu, Thomas D, Grant, Jessica M, Grandner, Anna, Shiriaeva, Reid H J, Olsen, Alexandra R, Tribo, Saïd, Yous, Raymond C, Stevens, Uwe, Weierstall, Vsevolod, Katritch, Bryan L, Roth, Wei, Liu, Vadim, Cherezov
Publikováno v:
Nature. 569(7755)
Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that maintains circadian rhythms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ded7b9d8c0da8adffbfaac5c60b4649b
https://pubmed.ncbi.nlm.nih.gov/31048811
https://pubmed.ncbi.nlm.nih.gov/31048811
Autor:
Vadim Cherezov, Gye Won Han, Linda C. Johansson, Benjamin Stauch, Alexander Batyuk, Andrii Ishchenko
Publikováno v:
X-ray Free Electron Lasers ISBN: 9783030005504
G protein-coupled receptors (GPCRs) constitute the largest superfamily of membrane proteins, members of which are involved in regulation of critical sensory and physiological processes in the human body. High-resolution GPCR structures are essential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e52515d9ccd0cac1b0a5851805e82b13
https://doi.org/10.1007/978-3-030-00551-1_10
https://doi.org/10.1007/978-3-030-00551-1_10