Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Linda C. Hsi"'
Autor:
Shefaa AlAsfoor, Cheryl E. Bernard, Erik Jessen, Vernadette A. Simon, Fariborz Rakhshan, Gianluca Cipriani, Linda C. Hsi, Jack A. Patraw, Kari J. Carothers, Julie S. Lau, Samantha J. McDonough, Surendra Dasari, Gianrico Farrugia, Madhusudan Grover
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103258- (2024)
Summary: Understanding the diversity of gastrointestinal (GI) immune cells, especially in the muscularis propria, is crucial for understanding their role in the maintenance of enteric neurons and smooth muscle and their contribution to GI motility. H
Externí odkaz:
https://doaj.org/article/c451e2ad6c914ccba7a3b09314efade5
Publikováno v:
Journal of Biological Chemistry. 288:2778-2788
IL-13 is a potent stimulator of alternative monocyte/macrophage activation. During alternative activation, the expression of several proteins is induced including 15-lipoxygenase (15-LO), a lipid-peroxidating enzyme and the scavenger receptor CD36. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa13284af173fea88c02412bdbbd8092
https://doi.org/10.1074/jbc.m112.381343
https://doi.org/10.1074/jbc.m112.381343
Autor:
Ryan Ficco, Bo Xu, Juan Martin Palomo, Linda C. Hsi, Michael A. Vogelbaum, Martha K. Cathcart, Suman Kundu
Publikováno v:
Molecular Cancer Therapeutics. 10:1149-1160
Glioblastoma multiforme (GBM) is one of the most lethal forms of cancer, with a survival rate of only 13% to 27% within 2 years of diagnosis despite optimal medical treatment. We hypothesize that the presence of a unique IL-13Rα2 decoy receptor prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b300447b9d15fd5ad7fa00497ca6d1a5
https://doi.org/10.1158/1535-7163.mct-10-1064
https://doi.org/10.1158/1535-7163.mct-10-1064
Publikováno v:
Molecular Cancer Therapeutics. 4:1740-1746
DNA methylation by DNA methyltransferases in CpG-rich promoter regions of genes is a well-described component of epigenetic silencing in human cells. Dysregulation of this process in cancer cells may lead to hypermethylation of promoter CpG islands,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f991647733bc6aaea265f0e8c07b224
https://doi.org/10.1158/1535-7163.mct-05-0218
https://doi.org/10.1158/1535-7163.mct-05-0218
Autor:
Rajeewa D. Abeysinghe, Linda C. Hsi, Renée Micielli, Terry Ball, Caroline Jill Rieke, Steve A. Seibold, Robert I. Cukier, William L. Smith, Denise A. Mills
Publikováno v:
Journal of Biological Chemistry. 278:46163-46170
Prostaglandin-endoperoxide H synthases (PGHSs) have a cyclooxygenase that forms prostaglandin (PG) G2 from arachidonic acid (AA) plus oxygen and a peroxidase that reduces the PGG2 to PGH2. The peroxidase activates the cyclooxygenase. This involves an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbaf910082b5838dbdefb8d6cfbbe29
https://doi.org/10.1074/jbc.m306319200
https://doi.org/10.1074/jbc.m306319200
Publikováno v:
Journal of Biological Chemistry. 278:5845-5853
Troglitazone (TGZ) is a peroxisome proliferator-activated receptor gamma (PPAR gamma) ligand that has pro-apoptotic activity in human colon cancer. Although TGZ binds to PPAR gamma transcription factors as an agonist, emerging evidence suggests that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb81abf7772a2ada1f75496baa78a53c
https://doi.org/10.1074/jbc.m208394200
https://doi.org/10.1074/jbc.m208394200
Publikováno v:
Journal of Biological Chemistry. 277:40549-40556
Human prostate tumors have elevated levels of 15-lipoxygenase-1 (15-LOX-1) and data suggest that 15-LOX-1 may play a role in the development of prostate cancer. In contrast, 15-LOX-2 expression is higher in normal rather than in tumor prostate tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0a603467ac21d0cd261d4d5278ce6a3
https://doi.org/10.1074/jbc.m203522200
https://doi.org/10.1074/jbc.m203522200
Publikováno v:
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA). 64:217-225
In human colorectal carcinoma Caco-2 cells, sodium butyrate (NaBT) induces the expression of the reticulocyte, 15-lipoxygenase-1 (15-LO-1) and causes these cells to undergo differentiation and apoptosis. 15-LO-1 is also expressed in human colorectal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d97b8f299cf4d1adccdfc5244ff8b9d
https://doi.org/10.1054/plef.2001.0263
https://doi.org/10.1054/plef.2001.0263
Publikováno v:
Experimental Cell Research. 256:563-570
Induction of cyclooxygenase-2 (COX-2) is an early event in the sequence of polyp formation to colon carcinogenesis. COX-2 is at elevated levels in human colorectal cancers and in tumors and polyps of mouse models of colorectal cancer. Mutation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ce74b50ae1b02c7faacc8bbd59b209
https://doi.org/10.1006/excr.2000.4863
https://doi.org/10.1006/excr.2000.4863
Autor:
Douglas C. Goodwin, Michael R. Gunther, Brenda C. Crews, Thomas E. Eling, Linda C. Hsi, Ronald P. Mason, Lawrence J. Marnett
Publikováno v:
Journal of Biological Chemistry. 273:8903-8909
Tyrosyl radicals have been detected during turnover of prostaglandin endoperoxide H synthase (PGHS), and they are speculated to participate in cyclooxygenase catalysis. Spectroscopic approaches to elucidate the identity of the radicals have not been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b82cfcbc347f46b21a3cf031669d63c2
https://doi.org/10.1074/jbc.273.15.8903
https://doi.org/10.1074/jbc.273.15.8903