Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Linda C. Andersson"'
Autor:
Chandrali Bhattacharya, Ann-Sofie Sandinge, Ryan A. Bragg, Maria Heijer, Jingjing Yan, Linda C. Andersson, Ulrik Jurva, Marta Pelay-Gimeno, Wouter H.J. Vaes, Rianne A.F. de Ligt, Malin Gränfors, Carl Amilon, Eva-Lotte Lindstedt, Somasekhara R. Menakuru, Pavlo Garkaviy, Lars Weidolf, V. Sashi Gopaul
Publikováno v:
Drug Metabolism and Disposition. 51:451-463
Autor:
Bhavik Chouhan, Dominic P. Williams, Magnus Söderberg, James W. Dear, Catherine C. Bell, Håkan Andersson, Linda C. Andersson
Publikováno v:
Archives of Toxicology
Bell, C C, Chouhan, B, Andersson, L C, Andersson, H, Dear, J, Williams, D P & Soderberg, M 2020, ' Functionality of primary hepatic non-parenchymal cells in a 3D spheroid model and contribution to acetaminophen hepatotoxicity. ', Archives of toxicology . https://doi.org/10.1007/s00204-020-02682-w)
Bell, C C, Chouhan, B, Andersson, L C, Andersson, H, Dear, J, Williams, D P & Soderberg, M 2020, ' Functionality of primary hepatic non-parenchymal cells in a 3D spheroid model and contribution to acetaminophen hepatotoxicity. ', Archives of toxicology . https://doi.org/10.1007/s00204-020-02682-w)
In addition to hepatocytes, the liver comprises a host of specialised non-parenchymal cells which are important to consider in the development of in vitro models which are both physiologically and toxicologically relevant. We have characterized a 3D
Autor:
Erio Barale, Katia Karalis, Riccardo Barrile, Kyung-Jin Jang, Monica Singer, Abhishek Srivastava, Anna Herland, Josiah Sliz, Barry Jones, Hyoungshin Park, Janna Nawroth, Geraldine A. Hamilton, Dominic P. Williams, Wing W. Lam, Gauri Kulkarni, Jonathan E. Rubins, Suzzette Haney, Linda C. Andersson, Manisha Sonee, Konstantia Kodella, Debora B. Petropolis, Monicah A. Otieno, Heng-Keang Lim, Lorna Ewart, Bhanu Singh, Carl L. Manthey, Janey Ronxhi, Donald E. Ingber, David Conegliano, Anthony J. Streeter, Damir Simic
Nonclinical rodent and non-rodent toxicity models used to support clinical trials of candidate drugs may produce discordant results or fail to predict complications in humans contributing to drug failures in the clinic. Here we applied microengineere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77153c2fec6be0820279936c4ea70992
Autor:
Bhanu Singh, Suzzette Haney, Carl L. Manthey, Riccardo Barrile, Anna Herland, Dominic P. Williams, Manisha Sonee, Katia Karalis, Monica Singer, David Conegliano, Heng-Keang Lim, Geraldine A. Hamilton, Donald E. Ingber, Monicah A. Otieno, Anthony J. Streeter, Lorna Ewart, Erio Barale, Linda C. Andersson, Barry Jones, Wing W. Lam, Damir Simic, Konstantia Kodella, Debora B. Petropolis, Josiah Sliz, Janey Ronxhi, Janna Nawroth, Abhishek Srivastava, Kyung-Jin Jang, Gauri Kulkarni, Hyoungshin Park, Jonathan E. Rubins
Publikováno v:
Science translational medicine. 11(517)
Nonclinical rodent and nonrodent toxicity models used to support clinical trials of candidate drugs may produce discordant results or fail to predict complications in humans, contributing to drug failures in the clinic. Here, we applied microengineer
Autor:
Stanley E. Lazic, Linda C. Andersson, Alison J. Foster, Helen Rollison, Sophie L. Regan, Geraldine A. Hamilton, Malin Darnell, Bhavik Chouhan, Jonathan Cairns, Dominic P. Williams, Abhishek Srivastava, Lorna Ewart, Paul Morgan, Kyung-Jin Jang, Sara Amberntsson, Jonathan E. Rubins, Konstantia Kodella, Debora B. Petropolis
Publikováno v:
Archives of toxicology. 93(4)
Drug-induced liver injury remains a frequent reason for drug withdrawal. Accordingly, more predictive and translational models are required to assess human hepatotoxicity risk. This study presents a comprehensive evaluation of two promising models to
Autor:
Anna Walentinsson, Marie Ahlqvist, Tommy B. Andersson, Matthew O'Hara, Kajsa P. Kanebratt, Alexander J. Kvist, Anders Björkbom, Linda C. Andersson, Henrik Palmgren
Publikováno v:
Biochemical pharmacology. 155
Primary human hepatocytes (PHH), HepaRG™, HepG2, and two sources of induced pluripotent stem cell (iPSC) derived hepatocytes were characterized regarding gene expression and function of key hepatic proteins, important for the metabolic fate of drug
Autor:
Linda C Andersson, Katarina A. L Rubin, Zsofia Berke, Tommy B. Andersson, Ken Grime, Annika Janefeldt
Publikováno v:
Drug Metabolism and Disposition. 43:119-125
The suppression of hepatic cytochrome P450 (P450) expression during inflammatory and infectious diseases and the relief of this suppression by successful disease treatment have been previously demonstrated to impact drug disposition. To address this
Autor:
Paul Morgan, Malin Darnell, Geraldine A. Hamilton, Sara Amberntsson, Helen Rollison, Lorna Ewart, Alison J. Foster, Dominic P. Williams, Kyung-Jin Jang, Sophie L. Regan, Linda C. Andersson, Jonathan E. Rubins, Abhishek Srivastava, Bhavik Chouhan, Konstantia Kodella, Debora B. Petropolis
Publikováno v:
Toxicology Letters. 295:S66
Autor:
Simone H. Stahl, Jonas Bergare, Marie Elebring, Richard A. Thompson, J. Gerry Kenna, Julie Eakins, Charles S. Elmore, Linda C. Andersson, Alison J. Foster, Martin Billger
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 352(2)
Drug-induced liver injury has been observed in patients treated with the endothelin receptor antagonists sitaxentan and bosentan, but not following treatment with ambrisentan. The aim of our studies was to assess the possible role of multiple contrib