Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Linda C Hackfeld"'
Autor:
Tuvshintugs Baljinnyam, Mark L Sowers, Chia Wei Hsu, James W Conrad, Jason L Herring, Linda C Hackfeld, Lawrence C Sowers
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0273509 (2022)
The DNA of all living organisms is persistently damaged by endogenous reactions including deamination and oxidation. Such damage, if not repaired correctly, can result in mutations that drive tumor development. In addition to chemical damage, recent
Externí odkaz:
https://doaj.org/article/7d52410c29cf4496b9561cc56bbf4cf7
Autor:
Mark L. Sowers, James W. Conrad, Bruce Chang-Gu, Ellie Cherryhomes, Linda C. Hackfeld, Lawrence C. Sowers
Publikováno v:
Molecules, Vol 28, Iss 3, p 970 (2023)
Although genomic DNA is predominantly duplex under physiological conditions, particular sequence motifs can favor the formation of alternative secondary structures, including the G-quadruplex. These structures can exist within gene promoters, telomer
Externí odkaz:
https://doaj.org/article/a33412c3fbe443a6b6675c6400251f67
Autor:
Tuvshintugs Baljinnyam, James W. Conrad, Mark L. Sowers, Bruce Chang-Gu, Jason L. Herring, Linda C. Hackfeld, Kangling Zhang, Lawrence C. Sowers
Publikováno v:
Chemical Research in Toxicology. 36:162-176
Autor:
Chia Wei Hsu, James W Conrad, Mark L Sowers, Tuvshintugs Baljinnyam, Jason L Herring, Linda C Hackfeld, Sandra S Hatch, Lawrence C Sowers
Publikováno v:
Nucleic acids research. 50(13)
DNA damage drives genetic mutations that underlie the development of cancer in humans. Multiple pathways have been described in mammalian cells which can repair this damage. However, most work to date has focused upon single lesions in DNA. We presen
Autor:
Chia Wei Hsu, Mark L. Sowers, Tuvshintugs Baljinnyam, Jason L. Herring, Linda C. Hackfeld, Hui Tang, Kangling Zhang, Lawrence C. Sowers
Publikováno v:
The Journal of biological chemistry. 298(3)
The hydrolytic deamination of cytosine and 5-methylcytosine drives many of the transition mutations observed in human cancer. The deamination-induced mutagenic intermediates include either uracil or thymine adducts mispaired with guanine. While a sub
Autor:
Meng Huang, Linda C. Hackfeld, Trevor M. Penning, Ian A. Blair, Clementina Mesaros, Richard P. Hodge, Tianzhu Zang
Publikováno v:
Chemical Research in Toxicology. 30:1093-1101
Exposure to petrogenic polycyclic aromatic hydrocarbons (PPAHs) in the food chain is the major human health hazard associated with the Deepwater Horizon oil spill. C4-Phenanthrenes are representative PPAHs present in the crude oil and could contamina
Autor:
Richard P. Hodge, Jayati Roy Choudhury, Jung Hoon Yoon, Jeseong Park, Linda C. Hackfeld, Louise Prakash, Satya Prakash
Publikováno v:
The Journal of biological chemistry. 293(8)
Acrolein, an α,β-unsaturated aldehyde, is generated in vivo as the end product of lipid peroxidation and from metabolic oxidation of polyamines, and it is a ubiquitous environmental pollutant. The reaction of acrolein with the N2 of guanine in DNA
Autor:
Ian A. Blair, Richard P. Hodge, Trevor M. Penning, Clementina Mesaros, Linda C. Hackfeld, Meng Huang
Publikováno v:
Chemical research in toxicology. 30(12)
Exposure to petrogenic polycyclic aromatic hydrocarbons (PPAHs) is the major human health hazard associated with the Deepwater Horizon oil spill. Alkylated phenanthrenes are the most abundant PPAHs present in the crude oil and could contaminate the f
Autor:
Trevor M. Penning, Richard P. Hodge, Ian A. Blair, Clementina Mesaros, Meng Huang, Li Zhang, Linda C. Hackfeld
Exposure to polycyclic aromatic hydrocarbons (PAHs) in the food chain is the major human health hazard associated with the Deepwater Horizon oil spill. C1-chrysenes are representative PAHs present in the crude oil and have been detected in contaminat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06164790cea970aaa9a21cccaf57147
https://europepmc.org/articles/PMC4709222/
https://europepmc.org/articles/PMC4709222/
Autor:
Ivan D. Kozekov, Priscilla H. Fernandes, Richard P. Hodge, Linda C. Hackfeld, R. Stephen Lloyd
Publikováno v:
Chemical Research in Toxicology. 19:968-976
1,3-Butadiene is a known carcinogen and mutagen that acts through a variety of metabolic intermediates that react with DNA, forming stable and unstable lesions on dG, dA, dC, and dT. The N3 2'-deoxyuridine adducts are a highly stable, stereoisomeric