Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Linda Burkly"'
Autor:
Daniel Sidler, Ping Wu, Rana Herro, Meike Claus, Dennis Wolf, Yuko Kawakami, Toshiaki Kawakami, Linda Burkly, Michael Croft
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
TWEAK is a TNF family member that binds the NFκB signalling receptor Fn14. Here the authors show that TWEAK is central to skin inflammation in mouse models of atopic dermatitis and psoriasis and causes similar pathology when injected subcutaneously
Externí odkaz:
https://doaj.org/article/be41c55c70374481a6ffc5f13f861470
Autor:
Anton Kichev, Ana A. Baburamani, Regina Vontell, Pierre Gressens, Linda Burkly, Claire Thornton, Henrik Hagberg
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine member of the TNF family. TWEAK binds to its only known receptor, Fn14, enabling it to activate downstream signaling processes in response to tissue inju
Externí odkaz:
https://doaj.org/article/62a4098eec1c4f3fa55364f625d9a144
Publikováno v:
Mediators of Inflammation, Vol 2014 (2014)
Externí odkaz:
https://doaj.org/article/1ab4f6ee1175455799d1e95efca84b7a
Autor:
Michele Masetti, Maria Chatzipetrou, Allan D. Kirk, Linda Burkly, David M. Harlan, Camillo Ricordi, Alessandra Ranuncoli, Maria Oliveira, Norma S. Kenyon, Joseph L. Wagner
Publikováno v:
Proceedings of the National Academy of Sciences. 96:8132-8137
Reported effects of anti-CD154 treatment on autoimmunity, alloreactivity, and inflammatory events mediated by macrophages and endothelial cells indicated that it might be an ideal agent for the prevention of intrahepatic islet allograft failure. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f751f3d6ca80f48e0e2f6fc50ad2e6b
https://doi.org/10.1073/pnas.96.14.8132
https://doi.org/10.1073/pnas.96.14.8132
Autor:
Thomas M. Kündig, Tak W. Mak, Ken Yamamoto, N. Kamikawaji, Richard Flavell, Josef M. Penninger, Pamela S. Ohashi, Takehiko Sasazuki, Linda Burkly, Rae S. M. Yeung, Yuk Law
Publikováno v:
The Journal of Experimental Medicine
To reconstitute the human immune system in mice, transgenic mice expressing human CD4 and human major histocompatibility complex (MHC) class II (DQw6) molecules in an endogenous CD4- and CD8-deficient background (mCD4/8-/-), after homologous recombin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033fc00b0382e17b2f9a0f11c0794b70
https://doi.org/10.1084/jem.180.5.1911
https://doi.org/10.1084/jem.180.5.1911
Autor:
Jing Wen, Chris Chen, Ariel Stock, Jessica Doerner, Linda Burkly, maria Gulinello, Kamran Khodakhah, Chaim Putterman
Publikováno v:
The Journal of Immunology. 194:186.2-186.2
Fn14, the sole receptor for the TNF family member TWEAK, is inducibly expressed in the brain in endothelial cells, astrocytes, microglia, and neurons. Previously, we had found that Fn14 knockout lupus MRL/lpr mice display significantly attenuated neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45c78e15105fdb1d8afd5c26af9eb5c1
https://doi.org/10.4049/jimmunol.194.supp.186.2
https://doi.org/10.4049/jimmunol.194.supp.186.2
Publikováno v:
The Journal of Immunology. 194:114.16-114.16
Cutaneous lupus erythematosus (CLE) in one of its various forms is seen in the majority of patients with systemic lupus. Photosensitivity is common in lupus, and sunlight (via UVB irradiation) is a well-recognized trigger of CLE. A TNF superfamily me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::824448233cc45dad6c4e1d0786f8445e
https://doi.org/10.4049/jimmunol.194.supp.114.16
https://doi.org/10.4049/jimmunol.194.supp.114.16
Autor:
Yumin Xia, Leal Herlitz, Simona Gindea, Jing Wen, Rahul Pawar, Alexander Misharin, Lan Wu, Ping Wu, Jennifer Michaelson, Linda Burkly, Chaim Putterman
Publikováno v:
The Journal of Immunology. 192:201.1-201.1
The TNF superfamily member TWEAK acts through its receptor, Fn14, to mediate several key pathological processes known to be involved in lupus nephritis. To explore the potential for renal protection by targeting this pathway, we introduced the Fn14 n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69485acdd203b7c583550ac96307ecd6
https://doi.org/10.4049/jimmunol.192.supp.201.1
https://doi.org/10.4049/jimmunol.192.supp.201.1
Autor:
Jessica Doerner, Jing Wen, Yumin Xia, Adam Friedman, Jennifer Michaelson, Linda Burkly, Lan Wu, Chaim Putterman
Publikováno v:
The Journal of Immunology. 192:176.15-176.15
Cutaneous manifestations are very common in the systemic autoimmune disease systemic lupus erythematosus (SLE). TWEAK is a soluble cytokine member of the TNF superfamily that binds to a sole receptor, Fn14. TWEAK/Fn14 signaling is involved in cell su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cfd84f2ab20dc0b928a142d8cf6acd4
https://doi.org/10.4049/jimmunol.192.supp.176.15
https://doi.org/10.4049/jimmunol.192.supp.176.15
Autor:
Jing Wen, Jessica Doerner, Ariel Stock, Rani Sellers, Linda Burkly, Maria Gulinello, Chaim Putterman
Publikováno v:
The Journal of Immunology. 192:115.9-115.9
Neuropsychiatric disease (NPSLE) is one of the most common manifestations of human lupus, but remains poorly understood. TWEAK is a cytokine member of the TNF superfamily; its sole receptor, Fn14, is expressed in brain endothelial cells, astrocytes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b12a72e93318a4b4920f621c6ef9cdc
https://doi.org/10.4049/jimmunol.192.supp.115.9
https://doi.org/10.4049/jimmunol.192.supp.115.9