Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Linda Baldini"'
Autor:
Chris Ebeling, Elizabeth A. Woolf, Dennis Huszar, Deborah L. Nagle, Sonja H. McGrail, Karen J. Moore, Barry J. Dussault, Paul Burn, Victoria Fairchild-Huntress, George A. Carlson, Peer Bork, Lisa DiRocco, Pei Ge, Jill Montagno, James Vitale, Lisa Holmgren, Linda Baldini, Julie Gilchrist, John Keilty
Publikováno v:
Nature. 398(6723)
Genetic studies have shown that mutations within the mahogany locus suppress the pleiotropic phenotypes, including obesity, of the agouti-lethal-yellow mutant. Here we identify the mahogany gene and its product; this study, to our knowledge, represen
Identification and Characterization of the Mouse Obesity Gene tubby: A Member of a Novel Gene Family
Autor:
Ye Wu, Nathan D Lakey, Thomas Brody, Karen J. Moore, Janice A. Culpepper, George A. Carlson, Lisa Holmgren, Geoffrey D Alperin, John Lee, Patrick W. Kleyn, Jim Deeds, Elizabeth A. Woolf, Don J Misumi, Lucy R Berkemeier, Olga Tayber, Chris Ebeling, Linda Baldini, Olga Charlat, Jacqueline C. Pulido, Pei Shu, M.Alexandra Glücksmann-Kuis, Geoffrey M. Duyk, Steve G. Kovats, Brenda Kennedy, Fiona Hawkins, Hong Chen, Wei Fan
Publikováno v:
Cell. (2):281-290
The mutated gene responsible for the tubby obesity phenotype has been identified by positional cloning. A single base change within a splice donor site results in the incorrect retention of a single intron in the mature tub mRNA transcript. The conse