Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Linda B. von Weymarn"'
Autor:
Linda B. von Weymarn, Xiaotong Lu, Nicole M. Thomson, Loic LeMarchand, Sungshim L. Park, Sharon E. Murphy
Publikováno v:
Chem Res Toxicol
Smoking intensity varies across smokers and is influenced by individual variability in the metabolism of nicotine, the major addictive agent in tobacco. Therefore, lung cancer risk, which varies by racial ethnic group is influenced by the primary cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e900c73b74bcfb72af3742a167c07a6b
https://doi.org/10.1021/acs.chemrestox.2c00413
https://doi.org/10.1021/acs.chemrestox.2c00413
Nicotine replacement therapy is often used to maintain smoking cessation. However, concerns exist about the safety of long-term nicotine replacement therapy use in ex-smokers and its concurrent use in smokers. In this study, we determined the effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d077e894dee27aac70d563d3143563fe
https://doi.org/10.1158/1940-6207.c.6544277
https://doi.org/10.1158/1940-6207.c.6544277
Perspectives on This Article from Chronic Nicotine Consumption Does Not Influence 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone–Induced Lung Tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc7fcc7976dc15558627c4f64a734c8
https://doi.org/10.1158/1940-6207.22524494.v1
https://doi.org/10.1158/1940-6207.22524494.v1
Autor:
Sungshim L. Park, Linda B. von Weymarn, Sharon E. Murphy, Loic LeMarchand, Maarit Tiirikainen, Irina Stepanov, Marc Parenteau
Publikováno v:
Chemical Research in Toxicology. 31:168-175
At similar smoking levels, African American’s lung cancer risk is as much as twice that of whites. We hypothesized that racial/ethnic differences in UDP-glucuronosyltransferase (UGT)-catalyzed glucuronidation of 4-(methylnitrosamino)-1-(3-pyridyl)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a59556b127d63f3feab338d4999b53e
https://doi.org/10.1021/acs.chemrestox.7b00264
https://doi.org/10.1021/acs.chemrestox.7b00264
Autor:
Medjda Bellamri, Francis Johnson, Radha Bonala, Robert J. Turesky, Linda B. von Weymarn, Lihua Yao
Publikováno v:
Arch Toxicol
Occupational and tobacco exposure to aromatic amines (AAs) including 4-aminobiphenyl (4-ABP) and 2-naphthylamine (2-NA) are associated with bladder cancer (BC) risk. Several epidemiological studies have also reported a possible role for structurally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47250b21694dd3d70171dc474d9b1f8a
https://europepmc.org/articles/PMC6714057/
https://europepmc.org/articles/PMC6714057/
Autor:
Romel P Dator, Linda B. von Weymarn, Cory J. Hooyman, Laura A. Maertens, Peter W. Villalta, Pramod Upadhyaya, Silvia Balbo, Sharon E. Murphy
Publikováno v:
Analytical chemistry. 90(20)
The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is a potent lung carcinogen and exerts its carcinogen effects upon metabolic activation. The identification and quantitation of NNK metabolites could identify pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ca75a58b4bc54228448464c28fa069
https://pubmed.ncbi.nlm.nih.gov/30086646
https://pubmed.ncbi.nlm.nih.gov/30086646
Autor:
Laura J. Bierut, Sharon E. Murphy, A. Joseph Bloom, Alison Goate, Maribel Martinez, Linda B. von Weymarn
Publikováno v:
Pharmacogenetics and Genomics. 23:706-716
BACKGROUND To develop a predictive genetic model of nicotine metabolism. UDP-glucuronosyltransferase-2B10 (UGT2B10) is the primary catalyst of nicotine glucuronidation. MATERIALS AND METHODS The conversion of deuterated (D2)-nicotine to D2-nicotine-g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab34b14b986333c101b9b4a356aee3b7
https://doi.org/10.1097/fpc.0000000000000011
https://doi.org/10.1097/fpc.0000000000000011
Autor:
Sharon E. Murphy, Laura J. Bierut, Maribel Martinez, A. Joseph Bloom, Alison Goate, Linda B. von Weymarn
Publikováno v:
Pharmacogenetics and Genomics. 23:62-68
Flavin-containing monooxygenases (FMO) catalyze the metabolism of nucleophilic heteroatom-containing drugs and xenobiotics, including nicotine. Rare mutations in FMO3 are responsible for defective N-oxidation of dietary trimethylamine leading to trim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c854a3cdd6b9a6ca42fa7646e7c95a
https://doi.org/10.1097/fpc.0b013e32835c3b48
https://doi.org/10.1097/fpc.0b013e32835c3b48
Autor:
Eric C. Donny, Sharon E. Murphy, Dorothy K. Hatsukami, Nicole M. Thomson, Linda B. von Weymarn
Publikováno v:
Chemical research in toxicology. 29(3)
Nicotine is the most abundant alkaloid in tobacco accounting for 95% of the alkaloid content. There are also several minor tobacco alkaloids; among these are nornicotine, anatabine, and anabasine. We developed and applied a 96 well plate-based capill
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082d59fcff67fee6d27f322145ef90b2
https://pubmed.ncbi.nlm.nih.gov/26825008
https://pubmed.ncbi.nlm.nih.gov/26825008
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 343:307-315
Nicotine, the major addictive agent in tobacco, is metabolized primarily by CYP2A6-catalyzed oxidation. The product of this reaction, 5'-hydroxynicotine, is in equilibrium with the nicotine Δ5'(1')iminium ion and is further metabolized to cotinine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2bd58384c49ae409e2aac76a483a60
https://doi.org/10.1124/jpet.112.195255
https://doi.org/10.1124/jpet.112.195255