Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Linda B. Adams"'
Autor:
Sara Ballouz, Risa Karakida Kawaguchi, Maria T. Pena, Stephan Fischer, Megan Crow, Leon French, Frank M. Knight, Linda B. Adams, Jesse Gillis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Genetic and environmental variation are key contributors during organism development, but the influence of minor perturbations or noise is difficult to assess. This study focuses on the stochastic variation in allele-specific expression that
Externí odkaz:
https://doaj.org/article/dbed84c7e6f645c68b35621128732694
Publikováno v:
Emerging Infectious Diseases, Vol 28, Iss 3, Pp 749-751 (2022)
The treatment of leprosy is long and complex, benefiting from the development of sterilizing, rapidly-acting drugs. Reductive evolution made Mycobacterium leprae exquisitely sensitive to Telacebec, a phase 2 drug candidate for tuberculosis. The unpre
Externí odkaz:
https://doaj.org/article/53bf318753124148a7988971ad8da103
Autor:
Maria Teresa Pena, Ramanuj Lahiri, Gigi J. Ebenezer, Stephen W. Wheat, John Figarola, Richard W. Truman, Linda B. Adams
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Mycobacterium leprae infection of peripheral nerves and the subsequent nerve function impairment (NFI), especially in response to reactional episodes, are hallmarks of leprosy. Improved treatments for M. leprae-induced nerve injury are needed, as mos
Externí odkaz:
https://doaj.org/article/fffb1c2834784935a5cbbda301c3c6c0
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)
Mycobacterium leprae, the causative agent of leprosy, is an obligate intracellular pathogen primarily residing within host macrophages and Schwann cells. Whole genome sequencing predicts a highly degraded genome with approximately one third of the co
Externí odkaz:
https://doaj.org/article/7c3a718263ed494091aeec13497346a1
Autor:
Natthida Tongluan, Layne T. Shelton, J. Hunter Collins, Patrick Ingraffia, Gregory McCormick, Maria Pena, Rahul Sharma, Ramanuj Lahiri, Linda B. Adams, Richard W. Truman, Kevin R. Macaluso
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Leprosy is a zoonosis in the southern United States involving humans and wild armadillos. The majority of patients presenting with zoonotic strains of Mycobacterium leprae note extensive outdoor activity but only rarely report any history of direct c
Externí odkaz:
https://doaj.org/article/6474a3f7ea9346d5a977f09fad885f71
Autor:
Nora Cardona-Castro, María Victoria Escobar-Builes, Héctor Serrano-Coll, Linda B. Adams, Ramanuj Lahiri
Publikováno v:
Emerging Infectious Diseases, Vol 28, Iss 5, Pp 1067-1068 (2022)
Leprosy is a granulomatous infection caused by infection with Mycobacterium leprae or M. lepromatosis. We evaluated skin biopsy and slit skin smear samples from 92 leprosy patients in Colombia by quantitative PCR. Five (5.4%) patients tested positive
Externí odkaz:
https://doaj.org/article/695642de87144d7b9e577f5a8e343e03
Autor:
Shannon M. Lenz, Jaymes H. Collins, Nashone A. Ray, Deanna A. Hagge, Ramanuj Lahiri, Linda B. Adams, Susilene Maria Tonelli Nardi
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 9 (2020)
Background Subclinical infection with Mycobacterium leprae is one potential source of leprosy transmission, and post-exposure prophylaxis (PEP) regimens have been proposed to control this source. Because PEP trials require considerable investment, we
Externí odkaz:
https://doaj.org/article/805180bb52f244ce8d7b4d55de82a19f
Autor:
Deanna A. Hagge, Pawan Parajuli, Chhatra B. Kunwar, Divya R.S.J.B. Rana, Ruby Thapa, Kapil D. Neupane, Peter Nicholls, Linda B. Adams, Annemieke Geluk, Mahesh Shah, Indra B. Napit
Publikováno v:
EBioMedicine, Vol 23, Iss C, Pp 119-124 (2017)
Background: >94% of new annual leprosy cases are diagnosed in populations co-endemic for soil-transmitted helminths (STH). STH can profoundly dysregulate host immune responses towards Th2 bias, which can be restored over time after deworming. We hypo
Externí odkaz:
https://doaj.org/article/e9ea3e576076414884ba4d8fe8ce4a8e
Autor:
Mariateresa Coppola, Susan J. F. van den Eeden, Naoko Robbins, Louis Wilson, Kees L. M. C. Franken, Linda B. Adams, Tom P. Gillis, Tom H. M. Ottenhoff, Annemieke Geluk
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Tuberculosis (TB) and leprosy still represent significant public health challenges, especially in low- and lower middle-income countries. Both poverty-related mycobacterial diseases require better tools to improve disease control. For leprosy, there
Externí odkaz:
https://doaj.org/article/49c9e376fa99417d989ffed5d1b239b3
Autor:
Rahul Sharma, Ramanuj Lahiri, David M. Scollard, Maria Pena, Diana L. Williams, Linda B. Adams, John Figarola, Richard W. Truman
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 1, Pp 19-24 (2013)
Leprosy (also known as Hansen’s disease) is an infectious peripheral neurological disorder caused by Mycobacterium leprae that even today leaves millions of individuals worldwide with life-long disabilities. The specific mechanisms by which this ba
Externí odkaz:
https://doaj.org/article/38434564fc1144518a2a84ecd9922453