Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Linda Ariza‐McNaughton"'
Autor:
Syed A. Mian, Linda Ariza‐McNaughton, Fernando Anjos‐Afonso, Remisha Gurung, Sophie Jackson, Aytug Kizilors, John Gribben, Dominique Bonnet
Publikováno v:
HemaSphere, Vol 8, Iss 5, Pp n/a-n/a (2024)
Abstract Immunodeficient mouse models are widely used for the assessment of human normal and leukemic stem cells. Despite the advancements over the years, reproducibility, as well as the differences in the engraftment of human cells in recipient mice
Externí odkaz:
https://doaj.org/article/ec46a21af9d6473380851a2260b85562
Autor:
Fernando Anjos-Afonso, Florian Buettner, Syed A. Mian, Hefin Rhys, Jimena Perez-Lloret, Manuel Garcia-Albornoz, Namrata Rastogi, Linda Ariza-McNaughton, Dominique Bonnet
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The trajectories of hematopoietic stem cells (HSCs) during lineage commitment are complex. Here, the authors use single cell RNA-sequencing and xenotransplantation to uncover CD34 + EPCR + (CD38/CD45RA)- HSCs, which high repopulating and self-renewal
Externí odkaz:
https://doaj.org/article/9098d9db691f404ea49a1ba5251c1c75
Autor:
William Grey, Samantha Atkinson, Beatrice Rix, Pedro Casado, Linda Ariza-McNaughton, Cathy Hawley, Miriam L. Sopoena, Katherine S. Bridge, David Kent, Pedro R. Cutillas, Dominique Bonnet
Publikováno v:
HemaSphere, Vol 7, Iss 3, p e853 (2023)
Long-term hematopoietic stem cells are rare, highly quiescent stem cells of the hematopoietic system with life-long self-renewal potential and the ability to transplant and reconstitute the entire hematopoietic system of conditioned recipients. Most
Externí odkaz:
https://doaj.org/article/4e0fa0757b774e4ca29813340f26d393
Autor:
Sara Campinoti, Asllan Gjinovci, Roberta Ragazzini, Luca Zanieri, Linda Ariza-McNaughton, Marco Catucci, Stefan Boeing, Jong-Eun Park, John C. Hutchinson, Miguel Muñoz-Ruiz, Pierluigi G. Manti, Gianluca Vozza, Carlo E. Villa, Demetra-Ellie Phylactopoulos, Constance Maurer, Giuseppe Testa, Hans J. Stauss, Sarah A. Teichmann, Neil J. Sebire, Adrian C. Hayday, Dominique Bonnet, Paola Bonfanti
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The thymus is essential for T cell maturation and selection, and thymic defects result in severe immune problems. Here the authors identify a thymus cell population that is expandable in vitro, and can repopulate natural thymic matrix to generate tis
Externí odkaz:
https://doaj.org/article/c841855db99048c2a21529c2cdc906b1
Autor:
Michelle Escobedo-Cousin, Nicola Jackson, Raquel Laza-Briviesca, Linda Ariza-McNaughton, Martha Luevano, Sophie Derniame, Sergio Querol, Michael Blundell, Adrian Thrasher, Bernat Soria, Nichola Cooper, Dominique Bonnet, Alejandro Madrigal, Aurore Saudemont
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0138623 (2015)
Cord blood (CB) is increasingly used as a source of hematopoietic stem cells (HSC) for transplantation. Low incidence and severity of graft-versus-host disease (GvHD) and a robust graft-versus-leukemia (GvL) effect are observed following CB transplan
Externí odkaz:
https://doaj.org/article/61338b5b55e84bd6ac0a9b65853c1cf0
Autor:
Juan José Lozano, Linda Ariza-McNaughton, Jonathan M. Irish, Syed A Mian, Benedetta Costantini, Judith C. W. Marsh, Dominique Bonnet, Shahram Kordasti, Thanos P. Mourikis, Shok Ping Lim, Pilar Perez Abellan, Giovanni A M Povoleri, Ghulam J. Mufti, Susanne Heck, Giovanna Lombardi, Ander Abarrategi, Shreyans Gandhi, Marc Martinez Llordella, Rita Antunes Dos Reis
Publikováno v:
Blood. 136:885-897
Idiopathic aplastic anemia (AA) has 2 key characteristics: an autoimmune response against hematopoietic stem/progenitor cells and regulatory T-cells (Tregs) deficiency. We have previously demonstrated reduction in a specific subpopulation of Treg in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c55ae0d92bc89d6a0015a27e7bff1ccb
https://doi.org/10.1182/blood.2019001347
https://doi.org/10.1182/blood.2019001347
Autor:
Sara Ali, Syed Mian, William Grey, Manuel Garcia-Albornoz, Fatihah Mohamad Nor, Aneesh Sharma, Samantha Atkinson, Linda Ariza McNaughton, John G. Gribben, Dominique Bonnet
Publikováno v:
Blood. 140:5781-5781
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ce8cc61ef96e90a34993720f5a84e1f
https://doi.org/10.1182/blood-2022-165316
https://doi.org/10.1182/blood-2022-165316
Autor:
Andrew Clear, Anna Castleton, James D. Cavenagh, Heather Oakervee, Farideh Miraki-Moud, Pedro R. Cutillas, Bella Patel, Koorosh Korfi, Linda Ariza McNaughton, C. Xintaropoulou, F. Mardakheh, Dominique Bonnet, Ania Wilczynska, I. Pislariu, Ai Nagano, Michael J Austin, Martyn T. Smith, Karla J. Suchacki, John G. Gribben, Mariarita Calaminici, Q. Heydt, David Taussig, B. Peck, William P. Cawthorn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Heydt, Q, Xintaropoulou, C, Clear, A, Austin, M, Pislariu, I, Miraki-Moud, F, Cutillas, P, Korfi, K, Calaminici, M, Cawthorn, W P, Oldknow, K, Nagano, A, Gribben, J G, Smith, M, Cavenagh, J D, Oakervee, O, Castleton, A, Taussig, D, Peck, B, Wilczynska, A, McNaughton, L, Bonnett, D, Mardakheh, F & Patel, B 2021, ' Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence ', Nature Communications . https://doi.org/10.1038/s41467-021-25540-4
Nature Communications
Heydt, Q, Xintaropoulou, C, Clear, A, Austin, M, Pislariu, I, Miraki-Moud, F, Cutillas, P, Korfi, K, Calaminici, M, Cawthorn, W P, Oldknow, K, Nagano, A, Gribben, J G, Smith, M, Cavenagh, J D, Oakervee, O, Castleton, A, Taussig, D, Peck, B, Wilczynska, A, McNaughton, L, Bonnett, D, Mardakheh, F & Patel, B 2021, ' Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence ', Nature Communications . https://doi.org/10.1038/s41467-021-25540-4
The specific niche adaptations that facilitate primary disease and Acute Lymphoblastic Leukaemia (ALL) survival after induction chemotherapy remain unclear. Here, we show that Bone Marrow (BM) adipocytes dynamically evolve during ALL pathogenesis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c220a94fddf24cc1f0df4340c2278b
https://eprints.gla.ac.uk/252357/1/252357.pdf
https://eprints.gla.ac.uk/252357/1/252357.pdf
Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells
Autor:
Ander Abarrategi, Henry Wood, Alexander E. Smith, Kar Lok Kong, Syed A Mian, Linda Ariza-McNaughton, Thomas Snoeks, Peter Johnson, Caroline A. Oedekoven, Ghulam J. Mufti, Kevin Rouault-Pierre, Antoniana Batsivari, Dominique Bonnet
Publikováno v:
Blood Cancer Discov
Myelodysplastic syndromes (MDS) are clonal stem cell diseases characterized mainly by ineffective hematopoiesis. Here, we present an approach that enables robust long-term engraftment of primary MDS stem cells (MDS-SC) in mice by implantation of huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5881a32be05364aa192a74f978a5b05
https://pubmed.ncbi.nlm.nih.gov/33778768
https://pubmed.ncbi.nlm.nih.gov/33778768
Autor:
Roberta Ragazzini, Luca Zanieri, Pierluigi G. Manti, Hans J. Stauss, Adrian Hayday, Constance Maurer, Sarah A. Teichmann, Stefan Boeing, Giuseppe Testa, Gianluca Vozza, Miguel Muñoz-Ruiz, John C Hutchinson, Sara Campinoti, Demetra Ellie Phylactopoulos, Dominique Bonnet, Neil J. Sebire, Paola Bonfanti, Linda Ariza-McNaughton, Marco Catucci, Jong-Eun Park, Carlo Emanuele Villa, Asllan Gjinovci
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
The thymus is a primary lymphoid organ, essential for T cell maturation and selection. There has been long-standing interest in processes underpinning thymus generation and the potential to manipulate it clinically, because alterations of thymus deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7b9c561ea535fc62e00013bd9c217e