Výsledky vyhledávání - "Linda Aalders"

Akademický článek

N-cadherin-mediated interaction with multiple myeloma cells inhibits osteoblast differentiation

Autor: Richard W.J. Groen, Martin F.M. de Rooij, Kinga A. Kocemba, Rogier M. Reijmers, Anneke de Haan-Kramer, Marije B. Overdijk, Linda Aalders, Henk Rozemuller, Anton C.M. Martens, P. Leif Bergsagel, Marie José Kersten, Steven T. Pals, Marcel Spaargaren

Publikováno v: Haematologica, Vol 96, Iss 11 (2011)

Background Multiple myeloma is a hematologic malignancy characterized by a clonal expansion of malignant plasma cells in the bone marrow, which is accompanied by the development of osteolytic lesions and/or diffuse osteopenia. The intricate bi-direct

Externí odkaz: https://doaj.org/article/4eb6c435303b45fba49c3954e4209c32

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Reconstructing the human hematopoietic niche in immunodeficient mice

Publikováno v: Blood, 120(3), e9-e16. American Society of Hematology
Groen, R W J, Noort, W A, Raymakers, R A, Prins, H-J, Aalders, L, Hofhuis, F M, Moerer, P, van Velzen, J F, Bloem, A C, van Kessel, B, Rozemuller, H, van Binsbergen, E, Buijs, A, Yuan, H, de Bruijn, J D, de Weers, M, Parren, P W H I, Schuringa, J J, Lokhorst, H M, Mutis, T & Martens, A C M 2012, ' Reconstructing the human hematopoietic niche in immunodeficient mice : opportunities for studying primary multiple myeloma ', Blood, vol. 120, no. 3, pp. e9-e16 . https://doi.org/10.1182/blood-2012-03-414920
Blood, 120(3), E9-E16. AMER SOC HEMATOLOGY

Interactions within the hematopoietic niche in the BM microenvironment are essential for maintenance of the stem cell pool. In addition, this niche is thought to serve as a sanctuary site for malignant progenitors during chemotherapy. Therapy resista

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c149343f1eb6720f867cbf4dec702f
https://doi.org/10.1182/blood-2012-03-414920

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N-cadherin-mediated interaction with multiple myeloma cells inhibits osteoblast differentiation

Autor: P. Leif Bergsagel, Kinga A. Kocemba, Martin F. M. de Rooij, Anton C.M. Martens, Marcel Spaargaren, Anneke de Haan-Kramer, Richard W.J. Groen, Marie José Kersten, Steven T. Pals, Henk Rozemuller, Marije B. Overdijk, Rogier M. Reijmers, Linda Aalders

Publikováno v: Haematologica, 96(11), 1653-1661. Ferrata Storti Foundation
Haematologica, 96(11), 1653-61. Ferrata Storti Foundation
Haematologica, 96(11), 1653. Ferrata Storti Foundation
Groen, R W J, de Rooij, M F M, Kocemba, K A, Reijmers, R M, de Haan-Kramer, A, Overdijk, M B, Aalders, L, Rozemuller, H, Martens, A C M, Bergsagel, P L, Kersten, M J, Pals, S T & Spaargaren, M 2011, ' N-cadherin-mediated interaction with multiple myeloma cells inhibits osteoblast differentiation ', Haematologica, vol. 96, no. 11, pp. 1653-61 . https://doi.org/10.3324/haematol.2010.038133

BACKGROUND: Multiple myeloma is a hematologic malignancy characterized by a clonal expansion of malignant plasma cells in the bone marrow, which is accompanied by the development of osteolytic lesions and/or diffuse osteopenia. The intricate bi-direc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733fd87c94636c7076444e62eaa471ba
https://dare.uva.nl/personal/pure/en/publications/ncadherinmediated-interaction-with-multiple-myeloma-cells-inhibits-osteoblast-differentiation(7a94f0dc-cd04-4ebc-910d-c9146278fe71).html

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Abstract PR12: Biological insights into tumor-bone marrow microenvironment interactions derived from a humanized murine model

Autor: Henk M. Lokhorst, Coleman Lindsley, Willy A. Noort, Li Pan, Anton C.M. Martens, Tuna Mutis, Benjamin L. Ebert, Megan Bariteau, Uli Steidl, Jessica Sigmans, Huipin Yuan, Jan Jacob Schuringa, Linda Aalders, Jon C. Aster, Constantine S. Mitsiades, Joost D. de Bruijn, Richard W.J. Groen, Reinier Raymakers

Publikováno v: Cancer Research. 75:PR12-PR12

Interactions with the hematopoietic niche in the bone marrow (BM) microenvironment are essential for hematopoietic stem cell (HSC) self-renewal. In addition, this niche is considered to serve as a sanctuary site for leukemic stem cells during chemoth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d12be40dafb1670f14a51e1670ce025e
https://doi.org/10.1158/1538-7445.chtme14-pr12

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Disregulated Osteogenesis By Mesenchymal Stromal Cells (MSC) After In Vivo Exposure To Multiple Myeloma: Studies In a Novel Humanized Mouse Model For Bone Remodelling In Myeloma

Autor: Constantine S. Mitsiades, Anton C.M. Martens, Aniek van Stralen, Huipin Yuan, Willy A. Noort, Jessica Sigmans, Linda Aalders, Richard W.J. Groen, Reinier Raymakers

Publikováno v: Blood. 122:1906-1906

Multiple myeloma (MM), a B-cell neoplasm characterized by a clonal expansion of malignant plasma cells in the bone marrow (BM), is accompanied by osteolytic lesions and/or diffuse osteopenia in up to 90% of the patients. Even after successful treatme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb93bff800d763e3e907edab06d52898
https://doi.org/10.1182/blood.v122.21.1906.1906

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Daratumumab, a Novel Therapeutic Human CD38 Monoclonal Antibody, Induces Killing of Refractory Patient-Derived Multiple Myeloma Cells, Growing in a Novel Humanized Mouse MM Model

Autor: Anton C.M. Martens, Henk M. Lokhorst, Willy A. Noort, Paul W. H. I. Parren, Joost D. de Bruijn, Richard W.J. Groen, Reinier Raymakers, Berris van Kessel, Andries C. Bloem, Huipin Yuan, Frans M. A. Hofhuis, Tuna Mutis, Linda Aalders, Jeroen J. Lammerts van Bueren, Jeroen F. van Velzen

Publikováno v: Blood. 120:940-940

Abstract 940 The evolution of multiple myeloma (MM) is a multi-step process during which mature B cells acquire genetic mutations in multiple genes, which typically takes place in the bone marrow (BM) microenvironment. This, together with the difficu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3aa21fd47daad9353592c9022860cc75
https://doi.org/10.1182/blood.v120.21.940.940

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Daratumumab, a Novel Human CD38 Monoclonal Antibody for Treatment of Multiple Myeloma, Prevents Intra-Medullary Spreading of Patient Derived Multiple Myeloma Cells Growing in a Humanized Mouse Model

Autor: Jeroen J. Lammerts van Bueren, Willy A. Noort, Henk M. Lokhorst, Tuna Mutis, Joost D. de Bruijn, Linda Aalders, Paul W. H. I. Parren, Richard W.J. Groen, Reinier Raymakers, Huipin Yuan, Anton C.M. Martens

Publikováno v: Blood. 120:1834-1834

Abstract 1834 During progression of Multiple Myeloma (MM), the disease spreads to multiple sites in the bone marrow (BM) and towards terminal stages also to extra-medullary sites. If spreading of MM cells via the circulation could be prevented, it wo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::845094c734228338c5823e8ab6305d0a
https://doi.org/10.1182/blood.v120.21.1834.1834

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Reconstructing the Human Hematopoietic Niche: Opportunities for Studying Normal and Malignant Hematopoiesis

Autor: Henk Rozemuller, Michel de Weers, Petra Moerer, Anton C.M. Martens, Willy A. Noort, Linda Aalders, Tuna Mutis, Paul W. H. I. Parren, Jan Jacob Schuringa, Henk M. Lokhorst, Frans M. A. Hofhuis, Joost D. de Bruijn, Richard W.J. Groen, Henk-Jan Prins, Reinier Raymakers, Berris van Kessel

Publikováno v: Blood. 118:3412-3412

Abstract 3412 Interactions with the hematopoietic niche in the bone marrow (BM) microenvironment are essential for hematopoietic stem cell (HSC) self-renewal. In addition, in hematological malignancies this niche is considered to serve as a sanctuary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ef4ea863f711e57ae5cc25736365594
https://doi.org/10.1182/blood.v118.21.3412.3412

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A Unique New Humanized Mouse Model for Multiple Myeloma (MM): Opportunities for Studying MM In Its Natural Environment and for Preclinical Testing

Autor: Anton C.M. Martens, Henk M. Lokhorst, Frans M. A. Hofhuis, Linda Aalders, Berris van Kessel, Michel de Weers, Richard W.J. Groen, Tuna Mutis

Publikováno v: Blood. 116:981-981

Abstract 981 Here we report the development of a unique mouse model to study the pathobiology of multiple myeloma (MM) by implementing a technology for creating a natural human bone environment in the immune deficient RAG2γ-/-c-/- mouse. To this end

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::979e8649eca35af962acd06c8f56a7ab
https://doi.org/10.1182/blood.v116.21.981.981

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