Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Linda A. Warnke"'
Autor:
Sherry F. Queener, Vivian Cody, Jim Pace, Dixy W. Green, Linda A. Warnke, Michael A. Ihnat, Yibin Zeng, Lu Lin, Wei Li, Aleem Gangjee
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:7324-7336
To optimize dual receptor tyrosine kinase (RTK) and dihydrofolate reductase (DHFR) inhibition, the E- and Z-isomers of 5-[2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamines (1a and 1b) were separated by HPLC and the X-ray crystal st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb30c9e6b007559f2d20b90bf070a20
https://doi.org/10.1016/j.bmc.2009.08.044
https://doi.org/10.1016/j.bmc.2009.08.044
Autor:
Jennifer C. Davey, Athena P. Nomikos, Brian P. Jackson, Linda A. Warnke, Julie A. Gosse, Thomas H. Hampton, Jessica E. Thorpe, Joshua W. Hamilton, Courtney D. Kozul, Michael A. Ihnat
Publikováno v:
Chemico-Biological Interactions. 173:129-140
Nutritional studies in laboratory animals have long shown that various dietary components can contribute to altered gene expression and metabolism, but diet alone has not been considered in whole animal genomic studies. In this study, global gene exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03894b366772ed7834261df6b81a53af
https://doi.org/10.1016/j.cbi.2008.02.008
https://doi.org/10.1016/j.cbi.2008.02.008
Autor:
Linda A. Warnke, Aleem Gangjee, Michael A. Ihnat, Jianming Yu, Ojas A. Namjoshi, Jessica E. Thorpe
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:5514-5528
Direct and indirect involvement of receptor tyrosine kinases (RTKs) in tumor growth and metastasis makes them ideal targets for anticancer therapy. A paradigm shift from inhibition of single RTK to inhibition of multiple RTKs has been recently demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1142f9304d06a7c93045807678419c93
https://doi.org/10.1016/j.bmc.2008.04.019
https://doi.org/10.1016/j.bmc.2008.04.019
Autor:
Joshua W. Hamilton, Linda A. Warnke, Jennifer C. Davey, Rebecca A. Mason, Viviane Bernardo, Angeline S. Andrew, Thomas H. Hampton, Michael A. Ihnat, Jessica E. Thorpe
Publikováno v:
Toxicological Sciences. 100:75-87
The mechanisms of action of drinking water arsenic in the lung and the threshold for biologic effects remain controversial. Our study utilizes Affymetrix 22,690 transcript oligonucleotide microarrays to assess the long-term effects of increasing dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800bb48541881a6eddd68d9cd1afb57c
https://doi.org/10.1093/toxsci/kfm200
https://doi.org/10.1093/toxsci/kfm200
Autor:
Jessica E. Thorpe, Ludovica Piconi, Linda A. Warnke, K. Ross, Antonio Ceriello, Michael A. Ihnat, Csaba Szabó, Chandrashekhar D. Kamat, A. Cselenyák, R. C. Kaltreider, Z. Lacza, S. Shakir, Dixy E. Green
Publikováno v:
Diabetologia. 50:1523-1531
A long-term 'memory' of hyperglycaemic stress, even when glycaemia is normalised, has been previously reported in endothelial cells. In this report we sought to duplicate and extend this finding.HUVECs and ARPE-19 retinal cells were incubated in 5 or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72b016526b2f403d16d1ddeebfd3366
https://doi.org/10.1007/s00125-007-0684-2
https://doi.org/10.1007/s00125-007-0684-2
Autor:
Antonio Ceriello, Michael A. Ihnat, Chandrashekhar D. Kamat, Linda A. Warnke, Jessica E. Thorpe, Dixy E. Green
Publikováno v:
Cancer Letters. 249:209-219
There is much controversy in the literature regarding the role of p53 status response on hypoxia inducible factor (HIF) signaling in response to chronic relative hypoxia (CRH). The goal of this paper was to methodically examine this response in isoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd5051d3020525345e72ed923029958
https://doi.org/10.1016/j.canlet.2006.08.017
https://doi.org/10.1016/j.canlet.2006.08.017
Publikováno v:
Biomedical Materials. 2:55-61
The angiogenic potential of a biomaterial is a critical factor for successful graft intake in tissue engineering. We developed a modified, rapid and reproducible chicken embryo chorioallantoic membrane (CAM) assay to evaluate the ability of biomateri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749219065d3aca44d2cc30fa115760b0
https://doi.org/10.1088/1748-6041/2/2/001
https://doi.org/10.1088/1748-6041/2/2/001
Autor:
Antonio Ceriello, Dixy E. Green, Amanda C. Shanner, Ludovica Piconi, Linda A. Warnke, Ronald C. Kaltreider, Melissa Leeper, Chandrashekhar D. Kamat, Michael A. Ihnat, Jessica E. Thorpe
Publikováno v:
American Journal of Biochemistry and Biotechnology. 3:16-23
High glucose, particularly in oscillating conditions, produces an increase in oxidative stress and has been shown to result in an increase in diabetic complications, retinopathy in particular. The hypothesis of this work was that chronic exposure to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5277b632a8fdce6aa646a73f0865689d
https://doi.org/10.3844/ajbbsp.2007.16.23
https://doi.org/10.3844/ajbbsp.2007.16.23
Autor:
Linda A. Warnke, Dixy W. Green, Fu Tyan Lin, Aleem Gangjee, Roy L. Kisliuk, Michael A. Ihnat, Yibin Zeng
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:5475-5491
Recent evidence suggests that combination therapy of cancer with receptor tyrosine kinase (RTK) inhibitors, which are usually cytostatic, with conventional chemotherapeutic agents, which are usually cytotoxic, provide an improved treatment option. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78998357cc028126c7a2ea2d1c8ab57e
https://doi.org/10.1016/j.bmc.2005.04.087
https://doi.org/10.1016/j.bmc.2005.04.087
Autor:
Stefan Stürup, Callie Clark, Joshua W. Hamilton, Dixy E. Green, Susan Curilla, Chandrashekhar D. Kamat, Michael A. Ihnat, Linda A. Warnke
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 86(2)
Trivalent inorganic arsenic (arsenite, arsenic trioxide, As(III)) is a primary contaminant of groundwater supplies worldwide. As(III), marketed as trisenox, is also an FDA-approved agent to treat cancer It has been previously shown by our laboratory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07a2f89051632c8f4f5a65d0cdc8e35
https://pubmed.ncbi.nlm.nih.gov/15888669
https://pubmed.ncbi.nlm.nih.gov/15888669