Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Linda A. Feagins"'
Autor:
Victoria Poplaski, Carolyn Bomidi, Amal Kambal, Hoa Nguyen-Phuc, Sara C. Di Rienzi, Heather A. Danhof, Xi-Lei Zeng, Linda A. Feagins, Nan Deng, Eduardo Vilar, Florencia McAllister, Cristian Coarfa, Soyoun Min, Hyun Jung Kim, Richa Shukla, Robert Britton, Mary K. Estes, Sarah E. Blutt
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
Cronkhite-Canada Syndrome (CCS) is a rare, noninherited polyposis syndrome affecting 1 in every million individuals. Despite over 50 years of CCS cases, the etiopathogenesis and optimal treatment for CCS remains unknown due to the rarity of the disea
Externí odkaz:
https://doaj.org/article/7d873d427aea4ddf8d9a215681dfd7ad
Autor:
Joseph A. Garcia, Rui Chen, Min Xu, Sarah A. Comerford, Robert E. Hammer, Shelby D. Melton, Linda A. Feagins
Publikováno v:
PLoS ONE, Vol 18, Iss 3 (2023)
The microenvironment of solid tumors is characterized by oxygen and glucose deprivation. Acss2/HIF-2 signaling coordinates essential genetic regulators including acetate-dependent acetyl CoA synthetase 2 (Acss2), Creb binding protein (Cbp), Sirtuin 1
Externí odkaz:
https://doaj.org/article/c0b1686f6e834cf1a5842d53a8811899
Publikováno v:
Intestinal Research, Vol 18, Iss 3, Pp 282-288 (2020)
Background/Aims Safety for tumor necrosis factor inhibitors (TNFi) in cancer has been focused on risk of incident malignancies, but studies on prognostic effects have been scarce. We determined survival and recurrence rates at 1, 2, and 5 years after
Externí odkaz:
https://doaj.org/article/e637e779141142c6b9c550b49f37518f
Autor:
Kibrom M. Alula, Dakota N. Jackson, Andrew D. Smith, Daniel S. Kim, Kevin Turner, Elizabeth Odstrcil, Benny A. Kaipparettu, Themistocles Dassopoulos, K. Venuprasad, Linda A. Feagins, Arianne L. Theiss
Publikováno v:
Cells, Vol 10, Iss 6, p 1349 (2021)
Paneth cell defects in Crohn’s disease (CD) patients (called the Type I phenotype) are associated with worse clinical outcomes. Recent studies have implicated mitochondrial dysfunction in Paneth cells as a mediator of ileitis in mice. We hypothesiz
Externí odkaz:
https://doaj.org/article/9a244ebc2520425894a647d83e021d73
Autor:
Benjamin R. Chebaa, Brandon Burgman, Andrew D. Smith, Daniel S. Kim, Tisha Lunsford, Miriam Mara, Leon Kundrotas, Kerry B. Dunbar, Stuart J. Spechler, S. Stephen Yi, Linda A. Feagins
Publikováno v:
Digestive Diseases and Sciences. 67:3210-3219
Autor:
Avneesh Chhabra, David I. Fudman, Andrew Gilman, Punya Chittajallu, Denisse Mendez, Yin Xi, Phillip Gu, Linda A. Feagins, Christopher Chang
Publikováno v:
Inflammatory Bowel Diseases. 28:657-666
Background Data describing the effect of obesity on antitumor necrosis factor (anti-TNF) treatment response are inconsistent. Visceral adipose tissue (VAT) is a superior marker of adiposity to body mass index. However, its effect on treatment respons
Autor:
Phillip Gu, Linda A. Feagins
Publikováno v:
Gastroenterology clinics of North America. 51(2)
Crohn's disease (CD) is chronic immune-related disease of the gastrointestinal tract hypothesized to be caused by an interplay of genetic predisposition and environmental exposures. With the global incidence increasing, more patients are exploring di
Autor:
Linda A. Feagins, Page C. Moore, Margaux M. Crabtree, Celeste A. Lemay, Anita M. Loughlin, Jill K. Gaidos
Publikováno v:
American Journal of Gastroenterology. 117:e639-e640
Autor:
Chandershekhar Shori, John Damianos, Clara DiVincenzo, Yetunde Ishola, Dagny Larson, Marissa Burgermaster, Jill K. Gaidos, Linda A. Feagins
Publikováno v:
American Journal of Gastroenterology. 117:e732-e733
Autor:
Jason C. Mills, Linda A. Feagins, Rhonda F. Souza, Arianne L. Theiss, LuAnn Thompson-Snipes, William L. Neumann, Marina Panopoulos, K. Venuprasad, Richard S. Blumberg, Kevin Turner, Themistocles Dassopoulos, Winston E. Thompson, Brandi L. Cantarel, Dakota N Jackson
Publikováno v:
Gut. 69:1928-1938
ObjectiveAlthough perturbations in mitochondrial function and structure have been described in the intestinal epithelium of Crohn’s disease and ulcerative colitis patients, the role of epithelial mitochondrial stress in the pathophysiology of infla