Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review

Autor: Jamie L. Felton, Maria J. Redondo, Richard A. Oram, Cate Speake, S. Alice Long, Suna Onengut-Gumuscu, Stephen S. Rich, Gabriela S. F. Monaco, Arianna Harris-Kawano, Dianna Perez, Zeb Saeed, Benjamin Hoag, Rashmi Jain, Carmella Evans-Molina, Linda A. DiMeglio, Heba M. Ismail, Dana Dabelea, Randi K. Johnson, Marzhan Urazbayeva, John M. Wentworth, Kurt J. Griffin, Emily K. Sims, On behalf of the ADA/EASD PMDI

Publikováno v: Communications Medicine, Vol 4, Iss 1, Pp 1-18 (2024)

Abstract Background Islet autoantibodies form the foundation for type 1 diabetes (T1D) diagnosis and staging, but heterogeneity exists in T1D development and presentation. We hypothesized that autoantibodies can identify heterogeneity before, at, and

Externí odkaz: https://doaj.org/article/113aed4f5d484c8ca50fd405d635e3a3

Disease-modifying therapies and features linked to treatment response in type 1 diabetes prevention: a systematic review

Autor: Jamie L. Felton, Kurt J. Griffin, Richard A. Oram, Cate Speake, S. Alice Long, Suna Onengut-Gumuscu, Stephen S. Rich, Gabriela S. F. Monaco, Carmella Evans-Molina, Linda A. DiMeglio, Heba M. Ismail, Andrea K. Steck, Dana Dabelea, Randi K. Johnson, Marzhan Urazbayeva, Stephen Gitelman, John M. Wentworth, Maria J. Redondo, Emily K. Sims, ADA/EASD PMDI

Publikováno v: Communications Medicine, Vol 3, Iss 1, Pp 1-16 (2023)

Abstract Background Type 1 diabetes (T1D) results from immune-mediated destruction of insulin-producing beta cells. Prevention efforts have focused on immune modulation and supporting beta cell health before or around diagnosis; however, heterogeneit

Externí odkaz: https://doaj.org/article/2767b39b5fa44f12be12f5096aacf63d

Growth differentiation factor 15 (GDF15) elevation in children with newly diagnosed cancer

Autor: Daniel V. Runco, Linda A. DiMeglio, Charles P. Vanderpool, Yan Han, Joanne Daggy, Mary M. Kelley, Raya Mikesell, Teresa A. Zimmers

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

BackgroundGrowth differentiation factor 15 (GDF15), an inflammatory marker and mediator of adult cancer cachexia, remains largely unexplored in children. GDF15 increases nausea, vomiting, and anorexia in cancer and contributes to malnutrition, with t

Externí odkaz: https://doaj.org/article/c572c3dfbd12454b998c485471dbb11d

Cause or effect? A review of clinical data demonstrating beta cell dysfunction prior to the clinical onset of type 1 diabetes

Autor: Emily K. Sims, Linda A. DiMeglio

Publikováno v: Molecular Metabolism, Vol 27, Iss , Pp S129-S138 (2019)

Background: Limited successes of conventional approaches to type 1 diabetes (T1D) prevention and treatment have highlighted the need for improved understanding of risk factors contributing to or hastening progression to clinical diagnosis. Scope of r

Externí odkaz: https://doaj.org/article/6e4f15713f044562965fc30e221f7583

Cambridge hybrid closed-loop algorithm in children and adolescents with type 1 diabetes: a multicentre 6-month randomised controlled trial

Autor: Julia Ware, MD, Charlotte K Boughton, PhD, Janet M Allen, RN, Malgorzata E Wilinska, PhD, Martin Tauschmann, PhD, Louise Denvir, MD, Ajay Thankamony, MPhil, Fiona M Campbell, MD, R Paul Wadwa, ProfMD, Bruce A Buckingham, ProfMD, Nikki Davis, MD, Linda A DiMeglio, ProfMD, Nelly Mauras, MD, Rachel E J Besser, PhD, Atrayee Ghatak, MD, Stuart A Weinzimer, ProfMD, Korey K Hood, ProfPhD, D Steven Fox, MD, Lauren Kanapka, MSc, Craig Kollman, PhD, Judy Sibayan, MPH, Roy W Beck, PhD, Roman Hovorka, ProfPhD, R Hovorka, C L Acerini, A Thankamony, J M Allen, C K Boughton, K Dovc, D B Dunger, J Ware, G Musolino, M Tauschmann, M E Wilinska, J F Hayes, S Hartnell, S Slegtenhorst, Y Ruan, M Haydock, J Mangat, L Denvir, SK Kanthagnany, J Law, T Randell, P Sachdev, M Saxton, A Coupe, S Stafford, A Ball, R Keeton, R Cresswell, L Crate, H Cripps, H Fazackerley, L Looby, H Navarra, C Saddington, V Smith, V Verhoeven, S Bratt, N Khan, L Moyes, K Sandhu, C West, R P Wadwa, G Alonso, G Forlenza, R Slover, L Towers, C Berget, A Coakley, E Escobar, E Jost, S Lange, L Messer, K Thivener, F M Campbell, J Yong, E Metcalfe, M Allen, S Ambler, S Waheed, J Exall, J Tulip, B A Buckingham, L Ekhlaspour, D Maahs, L Norlander, T Jacobson, M Twon, C Weir, B Leverenz, J Keller, N Davis, A Kumaran, N Trevelyan, H Dewar, G Price, G Crouch, R Ensom, L Haskell, LM Lueddeke, N Mauras, M Benson, K Bird, K Englert, J Permuy, K Ponthieux, J Marrero-Hernandez, L A DiMeglio, H Ismail, H Jolivette, J Sanchez, S Woerner, M Kirchner, M Mullen, M Tebbe, R EJ Besser, S Basu, R London, T Makaya, F Ryan, C Megson, J Bowen-Morris, J Haest, R Law, I Stamford, A Ghatak, M Deakin, K Phelan, K Thornborough, J Shakeshaft, S A Weinzimer, E Cengiz, J L Sherr, M Van Name, K Weyman, L Carria, A Steffen, M Zgorski, J Sibayan, R W Beck, S Borgman, J Davis, J Rusnak, A Hellman, P Cheng, L Kanapka, C Kollman, C McCarthy, S Chalasani, K K Hood, S Hanes, J Viana, M Lanning, D S Fox, G Arreaza-Rubin, T Eggerman, N Green, R Janicek, D Gabrielson, S H Belle, J Castle, J Green, L Legault, S M Willi, C Wysham

Publikováno v: The Lancet: Digital Health, Vol 4, Iss 4, Pp e245-e255 (2022)

Summary: Background: Closed-loop insulin delivery systems have the potential to address suboptimal glucose control in children and adolescents with type 1 diabetes. We compared safety and efficacy of the Cambridge hybrid closed-loop algorithm with us

Externí odkaz: https://doaj.org/article/9bf15c000c1f41e1bce13d4bb5d7e2c3