Zobrazeno 1 - 10
of 295
pro vyhledávání: '"Linda A. Bradley"'
Autor:
Gal Reches, Netta R. Blondheim Shraga, Florent Carrette, Assaf Malka, Natalia Saleev, Yehuda Gubbay, Offir Ertracht, Izhak Haviv, Linda M. Bradley, Fred Levine, Ron Piran
Publikováno v:
Inflammation and Regeneration, Vol 42, Iss 1, Pp 1-20 (2022)
Abstract Background Different factors may lead to hepatitis. Among which are liver inflammation and poisoning. We chose two hepatitis models, typical for these two underlying causes. Thus, we aimed to characterize the role of protease-activated recep
Externí odkaz:
https://doaj.org/article/3aba8cd15bd7498c934b490029892569
Autor:
Jennifer L. Hope, Dennis C. Otero, Eun-Ah Bae, Christopher J. Stairiker, Ashley B. Palete, Hannah A. Faso, Michelle Lin, Monique L. Henriquez, Sreeja Roy, Hyungseok Seo, Xue Lei, Eric S. Wang, Savio Chow, Roberto Tinoco, Gregory A. Daniels, Kevin Yip, Alexandre Rosa Campos, Jun Yin, Peter D. Adams, Anjana Rao, Linda M. Bradley
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112436- (2023)
Summary: PSGL-1 (P-selectin glycoprotein-1) is a T cell-intrinsic checkpoint regulator of exhaustion with an unknown mechanism of action. Here, we show that PSGL-1 acts upstream of PD-1 and requires co-ligation with the T cell receptor (TCR) to atten
Externí odkaz:
https://doaj.org/article/067e0e4ee8fd4b5a973b514304627b4f
Autor:
Marzia Scortegagna, Kathryn Hockemeyer, Igor Dolgalev, Joanna Poźniak, Florian Rambow, Yan Li, Yongmei Feng, Roberto Tinoco, Dennis C. Otero, Tongwu Zhang, Kevin Brown, Marcus Bosenberg, Linda M. Bradley, Jean-Christophe Marine, Ioannis Aifantis, Ze’ev A. Ronai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The ubiquitin ligase Siah2 has been implicated in immune responses. Here, the authors show that Siah2 null immune cells have an increased inflammatory response to inoculated melanoma cells, along with a reduced number of infiltrating immunosuppressiv
Externí odkaz:
https://doaj.org/article/b4571c9b4e094486a2056a1668569d65
Autor:
Roberto Tinoco, Emily N. Neubert, Christopher J. Stairiker, Monique L. Henriquez, Linda M. Bradley
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Effective T cell differentiation during acute virus infections leads to the generation of effector T cells that mediate viral clearance, as well as memory T cells that confer protection against subsequent reinfection. While inhibitory immune checkpoi
Externí odkaz:
https://doaj.org/article/b9bcee28e3d24f1e9ef09d6a55c91578
Autor:
Yan Li, Roberto Tinoco, Lisa Elmén, Igor Segota, Yibo Xian, Yu Fujita, Avinash Sahu, Raphy Zarecki, Kerrie Marie, Yongmei Feng, Ali Khateb, Dennie T. Frederick, Shiri K. Ashkenazi, Hyungsoo Kim, Eva Guijarro Perez, Chi-Ping Day, Rafael S. Segura Muñoz, Robert Schmaltz, Shibu Yooseph, Miguel A. Tam, Tongwu Zhang, Emily Avitan-Hersh, Lihi Tzur, Shoshana Roizman, Ilanit Boyango, Gil Bar-Sela, Amir Orian, Randal J. Kaufman, Marcus Bosenberg, Colin R. Goding, Bas Baaten, Mitchell P. Levesque, Reinhard Dummer, Kevin Brown, Glenn Merlino, Eytan Ruppin, Keith Flaherty, Amanda Ramer-Tait, Tao Long, Scott N. Peterson, Linda M. Bradley, Ze’ev A. Ronai
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
RNF5 is a ubiquitin ligase regulating ER stress response. Here the authors show that Rnf5 deficiency potentiates immune response against melanoma via altered microbiota, and isolate bacterial strains that confer the same phenotype to wild type mice.
Externí odkaz:
https://doaj.org/article/47e63127b17f4776963dab1e5a8faa8f
Autor:
Yan Li, Lisa Elmén, Igor Segota, Yibo Xian, Roberto Tinoco, Yongmei Feng, Yu Fujita, Rafael R. Segura Muñoz, Robert Schmaltz, Linda M. Bradley, Amanda Ramer-Tait, Raphy Zarecki, Tao Long, Scott N. Peterson, Ze’ev A. Ronai
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1753-1766.e6 (2020)
Summary: Growing evidence supports the importance of gut microbiota in the control of tumor growth and response to therapy. Here, we select prebiotics that can enrich bacterial taxa that promote anti-tumor immunity. Addition of the prebiotics inulin
Externí odkaz:
https://doaj.org/article/514aa5afbc774f0dad63305d1537f92d
Autor:
Jennifer L. Hope, Panagiota I. Spantidea, Caoimhe H. Kiernan, Christopher J. Stairiker, Laurine C. Rijsbergen, Marjan van Meurs, Inge Brouwers-Haspels, Yvonne M. Mueller, Delia J. Nelson, Linda M. Bradley, Joachim G. J. V. Aerts, Peter D. Katsikis
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
The immune system, and in particular, cytotoxic CD8+ T cells (CTLs), plays a vital part in the prevention and elimination of tumors. In many patients, however, CTL-mediated tumor killing ultimately fails in the clearance of cancer cells resulting in
Externí odkaz:
https://doaj.org/article/244d90e4006c4431ab1b57e407dbf2cf
Autor:
Megan S. Orlando, Linda D. Bradley
Publikováno v:
Obstetrics & Gynecology. 140:499-513
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dab1e51561b51f720078126590388852
https://doi.org/10.1097/aog.0000000000004898
https://doi.org/10.1097/aog.0000000000004898
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Effective adaptive immune responses are characterized by stages of development and maturation of T and B cell populations that respond to disturbances in the host homeostasis in cases of both infections and cancer. For the T cell compartment, this be
Externí odkaz:
https://doaj.org/article/69cfb3667b96436ab3b9bffae796676b
Autor:
Marzia Scortegagna, Yuanning Du, Linda M. Bradley, Kun Wang, Alfredo Molinolo, Eytan Ruppin, Rabi Murad, Ze'ev A. Ronai
Publikováno v:
Cancer Research.
Cellular components of the tumor microenvironment, including myeloid cells, play important roles in the progression of lung adenocarcinoma (LUAD) and its response to therapy. Here, we characterize the function of the ubiquitin ligases Siah1a/2 in reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aaadab17b9c35c7972109c7b45fd8d61
https://doi.org/10.1158/0008-5472.can-23-0258
https://doi.org/10.1158/0008-5472.can-23-0258