Ready and waiting to go

Autor: Laura Rivino, Linda Wooldridge

Publikováno v: eLife, Vol 12 (2023)

Some T cells that have been activated by a herpesvirus can also respond to SARS-CoV-2, even if the original herpesvirus infection happened before the COVID-19 pandemic.

Externí odkaz: https://doaj.org/article/f36f91b051ea41f3b2ef8735b0dbfe3b

Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia

Autor: Michaela Gregorova, Daniel Morse, Tarcisio Brignoli, Joseph Steventon, Fergus Hamilton, Mahableshwar Albur, David Arnold, Matthew Thomas, Alice Halliday, Holly Baum, Christopher Rice, Matthew B Avison, Andrew D Davidson, Marianna Santopaolo, Elizabeth Oliver, Anu Goenka, Adam Finn, Linda Wooldridge, Borko Amulic, Rosemary J Boyton, Daniel M Altmann, David K Butler, Claire McMurray, Joanna Stockton, Sam Nicholls, Charles Cooper, Nicholas Loman, Michael J Cox, Laura Rivino, Ruth C Massey

Publikováno v: eLife, Vol 9 (2020)

Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis

Externí odkaz: https://doaj.org/article/80d0b79d831147a8857f8e7ec24cafa9

Supplementary Figure S1 from Profound Inhibition of Antigen-Specific T-Cell Effector Functions by Dasatinib

Autor: Ruth Seggewiss, Hermann Einsele, David A. Price, Emma Gostick, Elisabeth Greiner, Josef Zezula, Andrew K. Sewell, Angharad Fenton-May, Matthew Clement, Linda Wooldridge, Carolin Dix, Ralf Weichsel

Supplementary Figure S1 from Profound Inhibition of Antigen-Specific T-Cell Effector Functions by Dasatinib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5821466118d913f354f426793e0511ce
https://doi.org/10.1158/1078-0432.22439325.v1

Prolonged T-cell activation and long COVID symptoms independently associate with severe disease at 3 months in a UK cohort of hospitalized COVID-19 patients

Autor: Marianna Santopaolo, Michaela Gregorova, Fergus Hamilton, David Arnold, Anna Long, Aurora Lacey, Elizabeth Oliver, Alice Halliday, Holly Baum, Kristy Hamilton, Rachel Milligan, Olivia Pearce, Lea Knezevic, Begonia Morales Aza, Alice Milne, Emily Milodowski, Rajeka Lazarus, Anu Goenka, Adam Finn, Nick Maskell, Andrew Davidson, Kathleen Gillespie, Linda Wooldridge, Laura Rivino

COVID-19 causes immune perturbations which may persist long-term, and patients frequently report ongoing symptoms for months after recovery. We assessed the extent and nature of immune activation at 3 months post hospital admission in patients with m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9240a30f2e953c4fd1e33afde53a2d34
https://doi.org/10.1101/2022.11.25.22282759

Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19

Autor: Christopher M Rice, Philip Lewis, Fernando M Ponce-Garcia, Willem Gibbs, Sarah Groves, Drinalda Cela, Fergus Hamilton, David Arnold, Catherine Hyams, Elizabeth Oliver, Rachael Barr, Anu Goenka, Andrew Davidson, Linda Wooldridge, Adam Finn, Laura Rivino, Borko Amulic

Publikováno v: Rice, C M, Lewis, P, Ponce-Garcia, F M, Gibbs, W, Groves, S, Cela, D, Hamilton, F, Arnold, D, Hyams, C, Oliver, E, Barr, R, Goenka, A, Davidson, A, Wooldridge, L, Finn, A, Rivino, L & Amulic, B 2022, ' Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19 ', Life Science Alliance, vol. 6, no. 2, e202201658, pp. 1-13 . https://doi.org/10.26508/lsa.202201658

Neutrophils are vital in defence against pathogens, but excessive neutrophil activity can lead to tissue damage and promote acute respiratory distress syndrome. COVID-19 is associated with systemic expansion of immature neutrophils, but the functiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101394793974f4e503b9f284a6d03748
https://doi.org/10.26508/lsa.202201658