Zobrazeno 1 - 10
of 552
pro vyhledávání: '"Linda, Partridge"'
Autor:
Maarouf Baghdadi, Tobias Nespital, Carolina Monzó, Joris Deelen, Sebastian Grönke, Linda Partridge
Publikováno v:
Molecular Metabolism, Vol 81, Iss , Pp 101902- (2024)
Objective: Rapamycin, a powerful geroprotective drug, can have detrimental effects when administered chronically. We determined whether intermittent treatment of mice can reduce negative effects while maintaining benefits of chronic treatment. Method
Externí odkaz:
https://doaj.org/article/a82a0bef98704f7ea031b10a51fa7346
Autor:
Javier Morón-Oset, Lilly Katharina Sophie Fischer, Nathalie Jauré, Pingze Zhang, Annika Julia Jahn, Tessa Supèr, André Pahl, Adrian M. Isaacs, Sebastian Grönke, Linda Partridge
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-28 (2023)
Abstract G4C2 hexanucleotide repeat expansions in a non-coding region of the C9orf72 gene are the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). G4C2 insertion length is variable, and patients can
Externí odkaz:
https://doaj.org/article/f57af59b4b8d485cbaeb003fa4f446ff
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The Cre-loxP system has been used to generate cell-type specific mutations in mice, allowing researchers to investigate the underlying biological mechanisms of disease. However, the Cre-recombinase alone can induce phenotypes that confound c
Externí odkaz:
https://doaj.org/article/b028f22cecb945f2b689e00e34a8a555
Autor:
Magda L Atilano, Alexander Hull, Catalina-Andreea Romila, Mirjam L Adams, Jacob Wildfire, Enric Ureña, Miranda Dyson, Jorge Ivan-Castillo-Quan, Linda Partridge, Kerri J Kinghorn
Publikováno v:
PLoS Genetics, Vol 19, Iss 12, p e1011063 (2023)
Mutations in the GBA1 gene cause the lysosomal storage disorder Gaucher disease (GD) and are the greatest known genetic risk factors for Parkinson's disease (PD). Communication between the gut and brain and immune dysregulation are increasingly being
Externí odkaz:
https://doaj.org/article/ac15018b4078410a9ca7e92d2fad388d
Autor:
Virender K. Sahota, Aelfwin Stone, Nathaniel S. Woodling, Jereme G. Spiers, Joern R. Steinert, Linda Partridge, Hrvoje Augustin
Publikováno v:
Open Biology, Vol 13, Iss 9 (2023)
Alterations in the neuromuscular system underlie several neuromuscular diseases and play critical roles in the development of sarcopenia, the age-related loss of muscle mass and function. Mammalian Myostatin (MST) and GDF11, members of the TGF-β sup
Externí odkaz:
https://doaj.org/article/52604fc9b84246b693fbae8899b28894
Autor:
Carolina Monzó, Lisonia Gkioni, Andreas Beyer, Dario Riccardo Valenzano, Sebastian Grönke, Linda Partridge
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112722- (2023)
Summary: Aging impairs the capacity to respond to novel antigens, reducing immune protection against pathogens and vaccine efficacy. Dietary restriction (DR) extends life- and health span in diverse animals. However, little is known about the capacit
Externí odkaz:
https://doaj.org/article/5ae3e8842d5b4add90a8f6f0dea4bb05
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 10 (2022)
Externí odkaz:
https://doaj.org/article/aa758ea584e343299173130a00706b1e
Autor:
Anchal Srivastava, Jiongming Lu, Dennis Said Gadalla, Oliver Hendrich, Sebastian Grönke, Linda Partridge
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Restriction of amino acids in the diet can extend lifespan in diverse species ranging from flies to mammals. However, the role of individual amino acids and the underlying molecular mechanisms are only partially understood. The evolutionarily conserv
Externí odkaz:
https://doaj.org/article/5cadd427e10948988df37e4225517bec
Autor:
Daniel K. Fabian, Matías Fuentealba, Handan Melike Dönertaş, Linda Partridge, Janet M. Thornton
Publikováno v:
Immunity & Ageing, Vol 18, Iss 1, Pp 1-18 (2021)
Abstract At first glance, longevity and immunity appear to be different traits that have not much in common except the fact that the immune system promotes survival upon pathogenic infection. Substantial evidence however points to a molecularly inter
Externí odkaz:
https://doaj.org/article/285ed99620f64e7b9f27de3fb390b3c8
Autor:
Valerie Kuan, Helen C. Fraser, Melanie Hingorani, Spiros Denaxas, Arturo Gonzalez-Izquierdo, Kenan Direk, Dorothea Nitsch, Rohini Mathur, Constantinos A. Parisinos, R. Thomas Lumbers, Reecha Sofat, Ian C. K. Wong, Juan P. Casas, Janet M. Thornton, Harry Hemingway, Linda Partridge, Aroon D. Hingorani
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Reducing the burden of late-life morbidity requires an understanding of the mechanisms of ageing-related diseases (ARDs), defined as diseases that accumulate with increasing age. This has been hampered by the lack of formal criteria to ident
Externí odkaz:
https://doaj.org/article/a4cfa63aeff54b99ac644b906f56e8bb