Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Linda, Lanting"'
Autor:
Maryam Abdollahi, Mitsuo Kato, Linda Lanting, Ragadeepthi Tunduguru, Mei Wang, Yangmeng Wang, Patrick T. Fueger, Qiong Wang, Wendong Huang, Rama Natarajan
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 115-130 (2022)
We investigated the role of microRNA (miR-379) in the pathogenesis of obesity, adipose tissue dysfunction, and insulin resistance (IR). We used miR-379 knockout (miR-379KO) mice to test whether loss of miR-379 affects high-fat diet (HFD)-induced obes
Externí odkaz:
https://doaj.org/article/98845e06c3e44f98a248b2f2ced158b5
Autor:
Mitsuo Kato, Zhuo Chen, Sadhan Das, Xiwei Wu, Jinhui Wang, Arthur Li, Wei Chen, Walter Tsark, Ragadeepthi Tunduguru, Linda Lanting, Mei Wang, Roger Moore, Markus Kalkum, Maryam Abdollahi, Rama Natarajan
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Background: MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) play key roles in diabetic kidney disease (DKD). The miR-379 megacluster of miRNAs and its host transcript lnc-megacluster (lncMGC) are regulated by transforming growth factor-β (TGF-
Externí odkaz:
https://doaj.org/article/44374e3670e84c119d07b8ac603d7f01
Autor:
Mitsuo Kato, Maryam Abdollahi, Ragadeepthi Tunduguru, Walter Tsark, Zhuo Chen, Xiwei Wu, Jinhui Wang, Zhen Bouman Chen, Feng-Mao Lin, Linda Lanting, Mei Wang, Janice Huss, Patrick T Fueger, David Chan, Rama Natarajan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Kato, Abdollahi et al. identify a redox protein thioredoxin and mitochondrial fission-1 (FIS1) protein as miR-379 targets in mouse kidney. They find that miR-379 knockout mice are protected from diabetic kidney disease by enhancing mitophagy via FIS1
Externí odkaz:
https://doaj.org/article/18cedf624dff4f77b17af0446ccad171
Autor:
Marpadga A. Reddy, Vishnu Amaram, Sadhan Das, Vinay Singh Tanwar, Rituparna Ganguly, Mei Wang, Linda Lanting, Lingxiao Zhang, Maryam Abdollahi, Zhuo Chen, Xiwei Wu, Sridevi Devaraj, Rama Natarajan
Publikováno v:
JCI Insight, Vol 6, Iss 11 (2021)
Long noncoding RNAs (lncRNAs) are increasingly implicated in the pathology of diabetic complications. Here, we examined the role of lncRNAs in monocyte dysfunction and inflammation associated with human type 2 diabetes mellitus (T2D). RNA sequencing
Externí odkaz:
https://doaj.org/article/5f467a5642364bdc98a43bb2b160a7be
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Autophagy plays a key role in the pathogenesis of kidney diseases, however its role in diabetic nephropathy (DN), and particularly in kidney glomerular mesangial cells (MCs) is not very clear. Transforming Growth Factor- β1 (TGF-β), a key
Externí odkaz:
https://doaj.org/article/5255ac3e313a425f815d571d439fd77b
Autor:
Vishnu Amaram Samara, Sadhan Das, Marpadga A. Reddy, Vinay Singh Tanwar, Kenneth Stapleton, Amy Leung, Maryam Abdollahi, Rituparna Ganguly, Linda Lanting, Rama Natarajan
Publikováno v:
Cells, Vol 10, Iss 10, p 2696 (2021)
Long non-coding RNAs (lncRNAs) play key roles in Angiotensin II (AngII) signaling but their role in chondrogenic transformation of vascular smooth muscle cells (VSMCs) is unknown. We describe a novel AngII-induced lncRNA Alivec (Angiotensin II-induce
Externí odkaz:
https://doaj.org/article/bf30d0f40d4f4e429a491aaf3b6ff8e0
Autor:
Mitsuo Kato, Maryam Abdollahi, Ragadeepthi Tunduguru, Walter Tsark, Zhuo Chen, Xiwei Wu, Jinhui Wang, Zhen Bouman Chen, Feng-Mao Lin, Linda Lanting, Mei Wang, Janice Huss, Patrick T. Fueger, David Chan, Rama Natarajan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-2 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-01691-4
Externí odkaz:
https://doaj.org/article/515667da48844983bf3a0b70664fa38a
Autor:
Sadhan Das, Parijat Senapati, Zhuo Chen, Marpadga A. Reddy, Rituparna Ganguly, Linda Lanting, Varun Mandi, Anita Bansal, Amy Leung, Selena Zhang, Ye Jia, Xiwei Wu, Dustin E. Schones, Rama Natarajan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
The repertoire of tissue-specific distal regulators of gene transcription enhancers defines homeostasis or disease. Here, the authors reveal the enhancer and super-enhancer signature of vascular smooth muscle cells under normal and angiotensin II sti
Externí odkaz:
https://doaj.org/article/c12c799c38c64e36a32adeb8061e24ec
Autor:
Vinay Singh Tanwar, Marpadga A. Reddy, Sadhan Das, Vishnu Amaram Samara, Maryam Abdollahi, Suchismita Dey, Vajir Malek, Rituparna Ganguly, Kenneth Stapleton, Linda Lanting, Patrick Pirrotte, Rama Natarajan
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology.
Background: Obesity and diabetes are associated with elevated free fatty acids like palmitic acid (PA), which promote chronic inflammation and impaired inflammation resolution associated with cardiometabolic disorders. Long noncoding RNAs (lncRNAs) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b55a55e54878fd9a453bf14c2d9e1da6
https://doi.org/10.1161/atvbaha.122.318536
https://doi.org/10.1161/atvbaha.122.318536
Autor:
Mitsuo Kato, Mei Wang, Zhuo Chen, Kirti Bhatt, Hyung Jung Oh, Linda Lanting, Supriya Deshpande, Ye Jia, Jennifer Y.C. Lai, Christopher L. O’Connor, YiFan Wu, Jeffrey B. Hodgin, Robert G. Nelson, Markus Bitzer, Rama Natarajan
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Nephropathy is a common and hard-to-treat consequence of diabetes. Here Kato et al. show that a megacluster of microRNAs regulates early development of diabetic nephropathy in mice, and that inhibition of the cluster's host long non-coding RNA transc
Externí odkaz:
https://doaj.org/article/1e41366d4ecd419690836c365275caed