Zobrazeno 1 - 10
of 261
pro vyhledávání: '"Linda, J Van Eldik"'
Autor:
Hilaree N. Frazier, David J. Braun, Caleb S. Bailey, Meggie J. Coleman, Verda A. Davis, Stephen R. Dundon, Christopher J. McLouth, Hana C. Muzyk, David K. Powell, Colin B. Rogers, Saktimayee M. Roy, Linda J. Van Eldik
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 40, Iss , Pp 100826- (2024)
Background: Inhibition of p38 alpha mitogen activated protein kinase (p38α) has shown great promise as a treatment for Alzheimer's disease (AD) in preclinical tests. However, previous preclinical studies were performed in “pure” models of AD pat
Externí odkaz:
https://doaj.org/article/88b7fccff3084851bc566ef4cb37065a
Autor:
Yuhao Min, Xue Wang, Özkan İş, Tulsi A. Patel, Junli Gao, Joseph S. Reddy, Zachary S. Quicksall, Thuy Nguyen, Shu Lin, Frederick Q. Tutor-New, Jessica L. Chalk, Adriana O. Mitchell, Julia E. Crook, Peter T. Nelson, Linda J. Van Eldik, Todd E. Golde, Minerva M. Carrasquillo, Dennis W. Dickson, Ke Zhang, Mariet Allen, Nilüfer Ertekin-Taner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Progressive supranuclear palsy (PSP) is a neurodegenerative parkinsonian disorder characterized by cell-type-specific tau lesions in neurons and glia. Prior work uncovered transcriptome changes in human PSP brains, although their cell-specif
Externí odkaz:
https://doaj.org/article/7eb936ba3b1b4dcfaae93bda5909f002
Autor:
Maria A. Telpoukhovskaia, Thomas J. Murdy, Olivia J. Marola, Kevin Charland, Michael MacLean, Tain Luquez, Alexandra M. Lish, Sarah Neuner, Amy Dunn, Kristen D. Onos, Jesse Wiley, Derek Archer, Matthew J. Huentelman, Matthias Arnold, Vilas Menon, Alison Goate, Linda J. Van Eldik, Paul R. Territo, Gareth R. Howell, Gregory W. Carter, Kristen M. S. O'Connell, Catherine C. Kaczorowski, the 2022 JAX CADR Workshop
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 1, Pp n/a-n/a (2024)
Abstract INTRODUCTION In September 2022, The Jackson Laboratory Center for Alzheimer's and Dementia Research (JAX CADR) hosted a workshop with leading researchers in the Alzheimer's disease and related dementias (ADRD) field. METHODS During the works
Externí odkaz:
https://doaj.org/article/cf95533f4c0f4321bd855f02582741fa
Autor:
Eseosa T. Ighodaro, Ryan K. Shahidehpour, Adam D. Bachstetter, Erin L. Abner, Ruth S. Nelson, David W. Fardo, Andy Y. Shih, Roger I. Grant, Janna H. Neltner, Frederick A. Schmitt, Gregory A. Jicha, Richard J. Kryscio, Donna M. Wilcock, Linda J. Van Eldik, Peter T. Nelson
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-15 (2023)
Abstract Cerebrovascular pathologies other than frank infarctions are commonly seen in aged brains. Here, we focus on multi-lumen vascular profiles (MVPs), which are characterized by multiple vessel lumens enclosed in a single vascular channel. Littl
Externí odkaz:
https://doaj.org/article/1b7a8921bec849f2afb0d08e63ee89b6
Autor:
Ruth S. Nelson, Erin L. Abner, Gregory A. Jicha, Frederick A. Schmitt, Jing Di, Donna M. Wilcock, Justin M. Barber, Linda J. Van Eldik, Yuriko Katsumata, David W. Fardo, Peter T. Nelson
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract In addition to the memory disorders and global cognitive impairment that accompany neurodegenerative diseases, behavioral and psychological symptoms of dementia (BPSD) commonly impair quality of life and complicate clinical management. To in
Externí odkaz:
https://doaj.org/article/f20b21f32736429c942d8f87267f61a3
Autor:
Nirmal Verma, Gopal Viswanathan Velmurugan, Edric Winford, Han Coburn, Deepak Kotiya, Noah Leibold, Laura Radulescu, Sanda Despa, Kuey C. Chen, Linda J. Van Eldik, Peter T. Nelson, Donna M. Wilcock, Gregory A. Jicha, Ann M. Stowe, Larry B. Goldstein, David K. Powel, Jeffrey H. Walton, Manuel F. Navedo, Matthew A. Nystoriak, Andrew J. Murray, Geert Jan Biessels, Claire Troakes, Henrik Zetterberg, John Hardy, Tammaryn Lashley, Florin Despa
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Converging data from humans and laboratory animals suggest that altering bloodborne amylin could potentially reduce cerebrovascular amylin deposits and Aβ pathology in Alzheimer’s disease brains.
Externí odkaz:
https://doaj.org/article/b6483589f28142ef83c37fe4a6e6a7dc
Autor:
Christopher E. Bauer, Valentinos Zachariou, Tiffany L. Sudduth, Linda J. Van Eldik, Gregory A. Jicha, Peter T. Nelson, Donna M. Wilcock, Brian T. Gold
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 2, Pp n/a-n/a (2023)
Abstract Introduction We evaluated the relationship between plasma levels of transactive response DNA binding protein of 43 kDa (TDP‐43) and neuroimaging (magnetic resonance imaging [MRI]) measures of brain structure in aging. Methods Plasma sample
Externí odkaz:
https://doaj.org/article/5ef99e64ce4a47b0a8e07bb46021b785
Autor:
David J Braun, Hilaree N Frazier, Verda A Davis, Meggie J Coleman, Colin B Rogers, Linda J Van Eldik
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0286495 (2023)
The p38 alpha mitogen-activated protein kinase (p38α) is linked to both innate and adaptive immune responses and is under investigation as a target for drug development in the context of Alzheimer's disease (AD) and other conditions with neuroinflam
Externí odkaz:
https://doaj.org/article/e9d4ebe406c843afb9f1b8f78af3fbef
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-17 (2020)
Abstract Background Elevated blood homocysteine levels, termed hyperhomocysteinemia (HHcy), is a prevalent risk factor for Alzheimer’s disease (AD) in elderly populations. While dietary supplementation of B-vitamins is a generally effective method
Externí odkaz:
https://doaj.org/article/732cc55350ca4962ae59a857730f4354
Autor:
David J. Braun, David K. Powell, Christopher J. McLouth, Saktimayee M. Roy, D. Martin Watterson, Linda J. Van Eldik
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
Alzheimer’s disease (AD) is the leading cause of dementia in the elderly, but therapeutic options are lacking. Despite long being able to effectively treat the ill-effects of pathology present in various rodent models of AD, translation of these st
Externí odkaz:
https://doaj.org/article/69a67c1f686b4320ba1c7d8c518ef159