Genome-wide association study of pathological gambling

Autor: Lang, M., Leménager, T., Streit, F., Fauth-Bühler, M., Frank, J., Juraeva, D., Witt, S.H., Degenhardt, F., Hofmann, A., Heilmann-Heimbach, S., Kiefer, F., Brors, B., Grabe, H.-J., John, U., Bischof, A., Bischof, G., Völker, U., Homuth, G., Beutel, M., Lind, P.A., Medland, S.E., Slutske, W.S., Martin, N.G., Völzke, H., Nöthen, M.M., Meyer, C., Rumpf, H.-J., Wurst, F.M., Rietschel, M., Mann, K.F.

Publikováno v: In European Psychiatry August 2016 36:38-46

Assessment of Bidirectional Relationships Between Physical Activity and Depression Among Adults A 2-Sample Mendelian Randomization Study

Autor: Choi, K.W., Chen, C.Y., Stein, M.B., Klimentidis, Y.C., Wang, M.J., Koenen, K.C., Smoller, J.W., Wray, N.R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E.M., Abdellaoui, A., Adams, M.J., Agerbo, E., Air, T., Andlauer, T.F.M., Bacanu, S.A., Baekvad-Hansen, M., Beekman, A.T.F., Bigdeli, T.B., Binder, E.B., Blackwood, D.H.R., Bryois, J., Buttenschon, H.N., Bybjerg-Grauholm, J., Cai, N., Castelao, E., Hvarregaard, J., Christensen, J.H., Clarke, T.K., Coleman, J.R.I., Colodro-Conde, L., Couvy-Duchesne, B., Craddock, N., Crawford, G.E., Davies, G., Deary, I.J., Degenhardt, F., Derks, E.M., Direk, N., Dolan, C.V., Dunn, E.C., Eley, T.C., Escott-Price, V., Kiadeh, F.F.H., Finucane, H.K., Forstner, A.J., Frank, J., Gaspar, H.A., Gill, M., Goes, F.S., Gordon, S.D., Grove, J., Hall, L.S., Hansen, C.S., Hansen, T.F., Herms, S., Hickie, I.B., Hoffmann, P., Homuth, G., Horn, C., Hottenga, J.J., Hougaard, D.M., Ising, M., Jansen, R., Jorgenson, E., Knowles, J.A., Kohane, I.S., Kraft, J., Kretzschmar, W., Krogh, J., Kutalik, Z., Li, Y.H., Lind, P.A., MacIntyre, D.J., MacKinnon, D.F., Maier, R.M., Marchini, J., McGrath, P., McGuffin, P., Medland, S.E., Mehta, D., Middeldorp, C.M., Mihailov, E., Milaneschi, Y., Milani, L., Mondimore, F.M., Montgomery, G.W., Mostafavi, S., Mullins, N., Nauck, M., Ng, B., Nivard, M.G., Nyholt, D.R., O'Reilly, P.F., Oskarsson, H., Owen, M.J., Painter, J.N., Pedersen, C.B., Pedersen, M.G., Peterson, R.E., Pettersson, E., Peyrot, W.J., Pistis, G., Posthuma, D., Quiroz, J.A., Qvist, P., Rice, J.P., Riley, B.P., Rivera, M., Saeed, S., Schoevers, R., Schulte, E.C., Shen, L., Shi, J.X., Shyn, S.I., Sigurdsson, E., Sinnamon, G.C.B., Smit, J.H., Smith, D.J., Stefansson, H., Steinberg, S., Streit, F., Strohmaier, J., Tansey, K.E., Teismann, H., Teumer, A., Thompson, W., Thomson, P.A., Thorgeirsson, T.E., Traylor, M., Treutlein, J., Trubetskoy, V., Uitterlinden, A.G., Umbricht, D., Auwera, S. van der, Hemert, A.M. van, Viktorin, A., Visscher, P.M., Wang, Y.P., Webb, B.T., Weinsheimer, S.M., Wellmann, J., Willemsen, G., Witt, S.H., Wu, Y., Xi, H.L.S., Yang, J., Zhang, F.T., Arolt, V., Baune, B.T., Berger, K., Boomsma, D.I., Cichon, S., Dannlowski, U., Geus, E.J.C. de, DePaulo, J.R., Domenici, E., Domschke, K., Esko, T., Grabe, H.J., Hamilton, S.P., Hayward, C., Heath, A.C., Kendler, K.S., Kloiber, S., Lewis, G., Li, Q.Q.S., Lucae, S., Madden, P.A.F., Magnusson, P.K., Martin, N.G., McIntosh, A.M., Metspalu, A., Mors, O., Mortensen, P.B., Nordentoft, M., Nothen, M.M., O'Donovan, M.C., Paciga, S.A., Pedersen, N.L., Penninx, B.W.J.H., Perlis, R.H., Porteous, D.J., Potash, J.B., Preisig, M., Rietschel, M., Schaefer, C., Schulze, T.G., Stefansson, K., Tiemeier, H., Uher, R., Volzke, H., Weissman, M.M., Werge, T., Lewis, C.M., Levinson, D.F., Breen, G., Borglum, A.D., Sullivan, P.F., Major Depressive Disorder Working

Publikováno v: Choi, K W, Chen, C-Y, Stein, M B, Klimentidis, Y C, Wang, M-J, Koenen, K C, Smoller, J W & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2019, ' Assessment of Bidirectional Relationships Between Physical Activity and Depression Among Adults : A 2-Sample Mendelian Randomization Study ', JAMA Psychiatry, vol. 76, no. 4, pp. 399-408 . https://doi.org/10.1001/jamapsychiatry.2018.4175
JAMA Psychiatry, 76(4), 399-408. AMER MEDICAL ASSOC
JAMA Psychiatry, 76(4), 399-408. American Medical Association
Choi, K W, Chen, C Y, Stein, M B, Klimentidis, Y C, Wang, M J, Koenen, K C, Smoller, J W & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2019, ' Assessment of bidirectional relationships between physical activity and depression among adults : A 2-Sample Mendelian Randomization Study ', JAMA Psychiatry, vol. 76, no. 4, pp. 399-408 . https://doi.org/10.1001/jamapsychiatry.2018.4175
JAMA psychiatry, 76(4), 399-408. American Medical Association
Choi, K W, Abdellaoui, A, Beekman, A T F, Derks, E M, Dolan, C V, Hottenga, J J, Jansen, R, Mbarek, H, Middeldorp, C M, Milaneschi, Y, Nivard, M G, Posthuma, D, Willemsen, G, Boomsma, D I, de Geus, E J C, Penninx, B W J H, Sullivan, P F & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2019, ' Assessment of bidirectional relationships between physical activity and depression among adults a 2-sample Mendelian randomization study ', JAMA Psychiatry, vol. 76, no. 4, pp. 399-408 . https://doi.org/10.1001/jamapsychiatry.2018.4175

Importance: Increasing evidence shows that physical activity is associated with reduced risk for depression, pointing to a potential modifiable target for prevention. However, the causality and direction of this association are not clear; physical ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab17463265a7b6c32312b9668ae25c3a
https://hdl.handle.net/1765/116928

Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland

Autor: Arnau-Soler, A., Macdonald-Dunlop, E., Adams, M.J., Clarke, T.K., MacIntyre, D.J., Milburn, K., Navrady, L., Hayward, C., McIntosh, A.M., Thomson, P.A., Wray, N.R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E.M., Abdellaoui, A., Agerbo, E., Air, T.M., Andlauer, T.F.M., Bacanu, S.A., Baekvad-Hansen, M., Beekman, A.T.F., Bigdeli, T.B., Binder, E.B., Blackwood, D.H.R., Bryois, J., Buttenscon, H.N., Bybjerg-Grauholm, J., Cai, N., Castelao, E., Christensen, J.H., Coleman, J.R.I., Colodro-Conde, L., Couvy-Duchesne, B., Craddock, N., Rawford, G.E.C., Davies, G., Deary, I.J., Degenhardt, F., Derks, E.M., Direk, N., Dolan, C.V., Dunn, E.C., Eley, T.C., Escott-Price, V., Kiadeh, F.F.H., Finucane, H.K., Foo, J.C., Forstner, A.J., Frank, J., Gaspar, H.A., Gill, M., Goes, F.S., Gordon, S.D., Grove, J., Hall, L.S., Hansen, C.S., Hansen, T.F., Herms, S., Hickie, I.B., Hoffmann, P., Homuth, G., Horn, C., Hottenga, J.J., Hougaard, D.M., Ising, M., Jansen, R., Jones, I., Jones, L.A., Jorgenson, E., Knowles, J.A., Kohane, I.S., Kraft, J., Kretzschmar, W.W., Krogh, J., Kutalik, Z., Li, Y.H., Lind, P.A., Macintyre, D.J., MacKinnon, D.F., Maier, R.M., Maier, W., Marchini, J., Mbarek, H., McGrath, P., McGuffin, P., Medland, S.E., Mehta, D., Middeldorp, C.M., Mihailov, E., Milaneschi, Y., Milani, L., Mondimore, F.M., Montgomery, G.W., Mostafavi, S., Mullins, N., Nauck, M., Ng, B., Nivard, M.G., Nyholt, D.R., O'Reilly, P.F., Oskarsson, H., Owen, M.J., Painter, J.N., Pedersen, C.B., Pedersen, M.G., Peterson, R.E., Pettersson, E., Peyrot, W.J., Pistis, G., Posthuma, D., Quiroz, J.A., Qvist, P., Rice, J.P., Riley, B.P., Rivera, M., Mirza, S.S., Schoevers, R., Schulte, E.C., Shen, L., Shi, J.X., Shyn, S.I., Sigurdsson, E., Sinnamon, G.C.B., Smit, J.H., Smith, D.J., Stefansson, H., Steinberg, S., Streit, F., Strohmaier, J., Tansey, K.E., Teismann, H., Teumer, A., Thompson, W., Thorgeirsson, T.E., Traylor, M., Treutlein, J., Trubetskoy, V., Uitterlinden, A.G., Umbricht, D., Auwera, S. van der, Hemert, A.M. van, Viktorin, A., Visscher, P.M., Wang, Y.P., Webb, B.T., Weinsheimer, S.M., Wellmann, J., Willemsen, G., Witt, S.H., Wu, Y., Xi, H.L.S., Yang, J., Zhang, F.T., Arolt, V., Baune, B.T., Berger, K., Boomsma, D.I., Cichon, S., Dannlowski, U., Geus, E.J.C. de, DePaulo, J.R., Domenici, E., Domschke, K., Esko, T., Grabe, H.J., Hamilton, S.P., Heath, A.C., Kendler, K.S., Kloiber, S., Lewis, G., Li, Q.Q.S., Lucae, S., Madden, P.A.F., Magnusson, P.K., Martin, N.G., Metspalu, A., Mors, O., Mortensen, P.B., Muller-Myhsok, B., Nordentoft, M., Nothen, M.M., O'Donovan, M.C., Paciga, S.A., Pedersen, N.L., Penninx, B.W.J.H., Perlis, R.H., Porteous, D.J., Potash, J.B., Preisig, M., Rietschel, M., Schaefer, C., Schulze, T.G., Smoller, J.W., Stefansson, K., Tiemeier, H., Uher, R., Volzke, H., Weissman, M.M., Werge, T., Lewis, C.M., Levinson, D.F., Breen, G., Borglum, A.S.D., Sullivan, P.F., Generation Scotland, Psychiat Genomics Consortium

Publikováno v: Translational Psychiatry, 9. NATURE PUBLISHING GROUP

Stress is associated with poorer physical and mental health. To improve our understanding of this link, we performed genome-wide association studies (GWAS) of depressive symptoms and genome-wide by environment interaction studies (GWEIS) of depressiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::bc638551a82ea0ff6b61793ca09fb0a5
https://doi.org/10.1038/s41398-018-0360-y

Quality of life in the CRITICS study, a multicenter randomized phase III trial of neo-adjuvant chemotherapy followed by surgery and chemotherapy or by surgery and chemoradiotherapy in resectable gastric cancer

Autor: Amelsfoort, R. van, Walraven, I., Jansen, E.P.M., Cats, A., Grieken, N.C.T. van, Aaronson, N.K., Boot, H., Lind, P.A., Kranenbarg, E.M.K., Nordsmark, M., Putter, H., Trip, A.K., Sandick, J.W. van, Sikorska, K., Tinteren, H. van, Velde, C.J.H. van de, Verheij, M.

Publikováno v: Journal of Clinical Oncology, 36(15)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::38429c8869f3cc411598fd5154258c63
https://hdl.handle.net/1887/96332

Directional dominance on stature and cognition in diverse human populations

Autor: Joshi, P.K., Esko, T., Mattsson, H., Eklund, N., Gandin, I., Nutile, T., Jackson, A.U., Schurmann, C., Smith, A.V., Zhang, W., Okada, Y., Stančáková, A., Faul, J.D., Zhao, W., Bartz, T.M., Concas, M.P., Franceschini, N., Enroth, S., Vitart, V., Trompet, S., Guo, X., Chasman, D.I., O'Connel, J.R., Corre, T., Nongmaithem, S.S., Chen, Y., Mangino, M., Ruggiero, D., Traglia, M., Farmaki, A.E., Kacprowski, T., Bjonnes, A., van der Spek, A., Wu, Y., Giri, A.K., Yanek, L.R., Wang, L., Hofer, E., Rietveld, C.A., McLeod, O., Cornelis, M.C., Pattaro, C., Verweij, N., Baumbach, C., Abdellaoui, A., Warren, H.R., Vuckovic, D., Mei, H., Bouchard, C., Perry, J.R., Cappellani, S., Mirza, S.S., Benton, M.C., Broeckel, U., Medland, S.E., Lind, P.A., Malerba, G., Drong, A., Yengo, L., Bielak, L.F., Zhi, D., van der Most, P.J., Shriner, D., Mägi, R., Hemani, G., Karaderi, T., Wang, Z., Liu, T., Demuth, I., Zhao, J.H., Meng, W., Lataniotis, L., van der Laan, S.W., Bradfield, J.P., Wood, A.R., Bonnefond, A., Ahluwalia, T.S., Hall, L.M., Salvi, E., Yazar, S., Carstensen, L., de Haan, H.G., Abney, M., Afzal, U., Allison, M.A., Amin, N., Asselbergs, F.W., Bakker, S.J., Barr, R.G., Baumeister, S.E., Benjamin, D.J., Bergmann, S., Boerwinkle, E., Bottinger, E.P., Campbell, A., Chakravarti, A., Chan, Y., Chanock, S.J., Chen, C., Chen, Y.D., Collins, F.S., Connell, J., Correa, A., Cupples, L.A., Smith, G.D., Davies, G., Dörr, M., Ehret, G., Ellis, S.B., Feenstra, B., Feitosa, M.F., Ford, I., Fox, C.S., Frayling, T.M., Friedrich, N., Geller, F., Scotland, G., Gillham-Nasenya, I., Gottesman, O., Graff, M., Grodstein, F., Gu, C., Haley, C., Hammond, C.J., Harris, S.E., Harris, T.B., Hastie, N.D., Heard-Costa, N.L., Heikkilä, K., Hocking, L.J., Homuth, G., Hottenga, J.J., Huang, J., Huffman, J.E., Hysi, P.G., Ikram, M.A., Ingelsson, E., Joensuu, A., Johansson, Å., Jousilahti, P., Jukema, J.W., Kähönen, M., Kamatani, Y., Kanoni, S., Kerr, S.M., Khan, N.M., Koellinger, P., Koistinen, H.A., Kooner, M.K., Kubo, M., Kuusisto, J., Lahti, J., Launer, L.J., Lea, R.A., Lehne, B., Lehtimäki, T., Liewald, D.C., Lind, L., Loh, M., Lokki, M.L., London, S.J., Loomis, S.J., Loukola, A., Lu, Y., Lumley, T., Lundqvist, A., Männistö, S., Marques-Vidal, P., Masciullo, C., Matchan, A., Mathias, R.A., Matsuda, K., Meigs, J.B., Meisinger, C., Meitinger, T., Menni, C., Mentch, F.D., Mihailov, E., Milani, L., Montasser, M.E., Montgomery, G.W., Morrison, A., Myers, R.H., Nadukuru, R., Navarro, P., Nelis, M., Nieminen, M.S., Nolte, I.M., O'Connor, G.T., Ogunniyi, A., Padmanabhan, S., Palmas, W.R., Pankow, J.S., Patarcic, I., Pavani, F., Peyser, P.A., Pietilainen, K., Poulter, N., Prokopenko, I., Ralhan, S., Redmond, P., Rich, S.S., Rissanen, H., Robino, A., Rose, L.M., Rose, R., Sala, C., Salako, B., Salomaa, V., Sarin, A.P., Saxena, R., Schmidt, H., Scott, L.J., Scott, W.R., Sennblad, B., Seshadri, S., Sever, P., Shrestha, S., Smith, B.H., Smith, J.A., Soranzo, N., Sotoodehnia, N., Southam, L., Stanton, A.V., Stathopoulou, M.G., Strauch, K., Strawbridge, R.J., Suderman, M.J., Tandon, N., Tang, S.T., Taylor, K.D., Tayo, B.O., Töglhofer, A.M., Tomaszewski, M., T?ernikova N., Tuomilehto, J., Uitterlinden, A.G., Vaidya, D., van Hylckama Vlieg, A., van Setten, J., Vasankari, T., Vedantam, S., Vlachopoulou, E., Vozzi, D., Vuoksimaa, E., Waldenberger, M., Ware, E.B., Wentworth-Shields, W., Whitfield, J.B., Wild, S., Willemsen, G., Yajnik, C.S., Yao, J., Zaza, G., Zhu, X., BioBank Japan, Project, Salem, R.M., Melbye, M., Bisgaard, H., Samani, N.J., Cusi, D., Mackey, D.A., Cooper, R.S., Froguel, P., Pasterkamp, G., Grant, S.F., Hakonarson, H., Ferrucci, L., Scott, R.A., Morris, A.D., Palmer, C.N., Dedoussis, G., Deloukas, P., Bertram, L., Lindenberger, U., Berndt, S.I., Lindgren, C.M., Timpson, N.J., Tönjes, A., Munroe, P.B., Sørensen, T.I., Rotimi, C.N., Arnett, D.K., Oldehinkel, A.J., Kardia, S.L., Balkau, B., Gambaro, G., Morris, A.P., Eriksson, J.G., Wright, M.J., Martin, N.G., Hunt, S.C., Starr, J.M., Deary, I.J., Griffiths, L.R., Tiemeier, H., Pirastu, N., Kaprio, J., Wareham, N.J., Pérusse, L., Wilson, J.G., Girotto, G., Caulfield, M.J., Raitakari, O., Boomsma, D.I., Gieger, C., van der Harst, P., Hicks, A.A., Kraft, P., Sinisalo, J., Knekt, P., Johannesson, M., Magnusson, P.K., Hamsten, A., Schmidt, R., Borecki, I.B., Vartiainen, E., Becker, D.M., Bharadwaj, D., Mohlke, K.L., Boehnke, M., van Duijn, C.M., Sanghera, D.K., Teumer, A., Zeggini, E., Metspalu, A., Gasparini, P., Ulivi, S., Ober, C., Toniolo, D., Rudan, I., Porteous, D.J., Ciullo, M., Spector, T.D., Hayward, C., Dupuis, J., Loos, R.J., Wright, A.F., Chandak, G.R., Vollenweider, P., Shuldiner, A.R., Ridker, P.M., Rotter, J.I., Sattar, N., Gyllensten, U., North, K.E., Pirastu, M., Psaty, B.M., Weir, D.R., Laakso, M., Gudnason, V., Takahashi, A., Chambers, J.C., Kooner, J.S., Strachan, D.P., Campbell, H., Hirschhorn, J.N., Perola, M., Pola?ek O., Wilson, J.F.

Publikováno v: Nature
Nature, 523(7561), 459-462. Nature Publishing Group
Nature (Lond.) 523 (2015): 459–462. doi:10.1038/nature14618
info:cnr-pdr/source/autori:Joshi P.K.; Esko T.; Mattsson H.; Eklund N.; Gandin I.; Nutile T.; Jackson A.U.; Schurmann C.; Smith A.V.; Zhang W.; Okada Y.; Stancakova A.; Faul J.D.; Zhao W.; Bartz T.M.; Concas M.P.; Franceschini N.; Enroth S.; Vitart V.; Trompet S.; Guo X.; Chasman D.I.; O'Connel J.R.; Corre T.; Nongmaithem S.S.; Chen Y.; Mangino M.; Ruggiero D.; Traglia M.; Farmaki A.-E.; Kacprowski T.; Bjonnes A.; Van Der Spek A.; Wu Y.; Giri A.K.; Yanek L.R.; Wang L.; Hofer E.; Rietveld C.A.; McLeod O.; Cornelis M.C.; Pattaro C.; Verweij N.; Baumbach C.; Abdellaoui A.; Warren H.R.; Vuckovic D.; Mei H.; Bouchard C.; Perry J.R.B.; Cappellani S.; Mirza S.S.; Benton M.C.; Broeckel U.; Medland S.E.; Lind P.A.; Malerba G.; Drong A.; Yengo L.; Bielak L.F.; Zhi D.; Van Der Most P.J.; Shriner D.; Magi R.; Hemani G.; Karaderi T.; Wang Z.; Liu T.; Demuth I.; Zhao J.H.; Meng W.; Lataniotis L.; Van Der Laan S.W.; Bradfield J.P.; Wood A.R.; Bonnefond A.; Ahluwalia T.S.; Hall L.M.; Salvi E.; Yazar S.; Carstensen L.; De Haan H.G.; Abney M.; Afzal U.; Allison M.A.; Amin N.; Asselbergs F.W.; Bakker S.J.L.; Barr R.G.; Baumeister S.E.; Benjamin D.J.; Bergmann S.; Boerwinkle E.; Bottinger E.P.; Campbell A.; Chakravarti A.; Chan Y.; Chanock S.J.; Chen C.; Chen Y.-D.I.; Collins F.S.; Connell J.; Correa A.; Cupples L.A.; Smith G.D.; Davies G.; Dorr M.; Ehret G.; Ellis S.B.; Feenstra B.; Feitosa M.F.; Ford I.; Fox C.S.; Frayling T.M.; Friedrich N.; Geller F.; Scotland G.; Gillham-Nasenya I.; Gottesman O.; Graff M.; Grodstein F.; Gu C.; Haley C.; Hammond C.J.; Harris S.E.; Harris T.B.; Hastie N.D.; Heard-Costa N.L.; Heikkila K.; Hocking L.J.; Homuth G.; Hottenga J.-J.; Huang J.; Huffman J.E.; Hysi P.G.; Ikram M.A.; Ingelsson E.; Joensuu A.; Johansson A.; Jousilahti P.; Jukema J.W.; Kahonen M.; Kamatani Y.; Kanoni S.; Kerr S.M.; Khan N.M.; Koellinger P.; Koistinen H.A.; Kooner M.K.; Kubo M.; Kuusisto J.; Lahti J.; Launer L.J.; Lea R.A.; Lehne B.; Lehtimaki T.; Liewald D.C.M.; Lind L.; Loh M.; Lokki M.-L.; London S.J.; Loomis S.J.; Loukola A.; Lu Y.; Lumley T.; Lundqvist A.; Mannisto S.; Marques-Vidal P.; Masciullo C.; Matchan A.; Mathias R.A.; Matsuda K.; Meigs J.B.; Meisinger C.; Meitinger T.; Menni C.; Mentch F.D.; Mihailov E.; Milani L.; Montasser M.E.; Montgomery G.W.; Morrison A.; Myers R.H.; Nadukuru R.; Navarro P.; Nalis M.; Nieminen M.S.; Nolte I.M.; O'Connor G.T.; Ogunniyi A.; Padmanabhan S.; Palmas W.R.; Pankow J.S.; Patarcic I.; Pavani F.; Peyser P.A.; Pietilainen K.; Poulter N.; Prokopenko I.; Ralhan S.; Redmond P.; Rich S.S.; Rissanen H.; Robino A.; Rose L.M.; Rose R.; Sala C.; Salako B.; Salomaa V.; Sarin A.-P.; Saxena R.; Schmidt H.; Scott L.J.; Scott W.R.; Sennblad B.; Seshadri S.; Sever P.; Shrestha S.; Smith B.H.; Smith J.A.; Soranzo N.; Sotoodehnia N.; Southam L.; Stanton A.V.; Stathopoulou M.G.; Strauch K.; Strawbridge R.J.; Suderman M.J.; Tandon N.; Tang S.-T.; Taylor K.D.; Tayo B.O.; Toglhofer A.M.; Tomaszewski M.; Tsernikova N.; Tuomilehto J.; Uitterlinden A.G.; Vaidya D.; Van Hylckama Vlieg A.; Van Setten J.; Vasankari T.; Vedantam S.; Vlachopoulou E.; Vozzi D.; Vuoksimaa E.; Waldenberger M.; Ware E.B.; Wentworth-Shields W.; Whitfield J.B.; Wild S.; Willemsen G.; Yajnik C.S.; Yao J.; Zaza G.; Zhu X.; Salem R.M.; Melbye M.; Bisgaard H.; Samani N.J.; Cusi D.; Mackey D.A.; Cooper R.S.; Froguel P.; Pasterkamp G.; Grant S.F.A.; Hakonarson H.; Ferrucci L.; Scott R.A.; Morris A.D.; Palmer C.N.A.; Dedoussis G.; Deloukas P.; Bertram L.; Lindenberger U.; Berndt S.I.; Lindgren C.M.; Timpson N.J.; Tonjes A.; Munroe P.B.; Sorensen T.I.A.; Rotimi C.N.; Arnett D.K.; Oldehinkel A.J.; Kardia S.L.R.; Balkau B.; Gambaro G.; Morris A.P.; Eriksson J.G.; Wright M.J.; Martin N.G.; Hunt S.C.; Starr J.M.; Deary I.J.; Griffiths L.R.; Tiemeier H.; Pirastu N.; Kaprio J.; Wareham N.J.; Perusse L.; Wilson J.G.; Girotto G.; Caulfield M.J.; Raitakari O.; Boomsma D.I.; Gieger C.; Van Der Harst P.; Hicks A.A.; Kraft P.; Sinisalo J.; Knekt P.; Johannesson M.; Magnusson P.K.E.; Hamsten A.; Schmidt R.; Borecki I.B.; Vartiainen E.; Becker D.M.; Bharadwaj D.; Mohlke K.L.; Boehnke M.; Van Duijn C.M.; Sanghera D.K.; Teumer A.; Zeggini E.; Metspalu A.; Gasparini P.; Ulivi S.; Ober C.; Toniolo D.; Rudan I.; Porteous D.J.; Ciullo M.; Spector T.D.; Hayward C.; Dupuis J.; Loos R.J.F.; Wright A.F.; Chandak G.R.; Vollenweider P.; Shuldiner A.R.; Ridker P.M.; Rotter J.I.; Sattar N.; Gyllensten U.; North K.E.; Pirastu M.; Psaty B.M.; Weir D.R.; Laakso M.; Gudnason V.; Takahashi A.; Chambers J.C.; Kooner J.S.; Strachan D.P.; Campbell H.; Hirschhorn J.N.; Perola M.; Polasek O.; Wilson J.F./titolo:Directional dominance on stature and cognition in diverse human populations/doi:10.1038%2Fnature14618/rivista:Nature (Lond.)/anno:2015/pagina_da:459/pagina_a:462/intervallo_pagine:459–462/volume:523
Nature, vol. 523, no. 7561, pp. 459-462
Joshi, P K, Esko, T, Mattsson, H, Eklund, N, Gandin, I, Nutile, T, Jackson, A U, Schurmann, C, Smith, A V, Zhang, W, Okada, Y, Stancáková, A, Faul, J D, Zhao, W, Bartz, T M, Pina Concas, M, Franceschini, N, Enroth, S, Vitart, V, Trompet, S, Guo, X, Chasman, D I, O'Connel, J R, Corre, T, Nongmaithem, S S, Chen, Y, Mangino, M, Ruggiero, D, Traglia, M, Farmaki, A-E, Kacprowski, T, Bjonnes, A, Spek, A, Wu, Y, Giri, A K, Yanek, L R, Wang, L, Hofer, E, Rietveld, C A, McLeod, O, Cornelis, M C, Pattaro, C, Verweij, N, Baumbach, C, Abdellaoui, A, Warren, H R, Vuckovic, D, Mei, H, Bouchard, C, Perry, J R B, Cappellani, S, Mirza, S S, Benton, M C, Broeckel, U, Medland, S E, Lind, P A, Malerba, G, Drong, A, Yengo, L, Bielak, L F, Zhi, D, van der Most, P J, Shriner, D, Mägi, R, Hemani, G, Karaderi, T, Wang, Z, Liu, T, Demuth, I, Zhao, J H, Meng, W, Lataniotis, L, van der Laan, S W, Brafdfield, J P, Wood, A R, Bonnefond, A, Ahluwalia, T S, Hall, L M, Salvi, E, Yazar, S, Carstensen, L, de Haan, H G, Abney, M, Afzal, U, Allison, M A, Amin, N, Asselbergs, F W, Bakker, S J L, Barr, R G, Baumeister, S E, Benjamin, D J, Bergmann, S, Boerwinkle, E, Bottinger, E P, Campbell, A, Chakravarti, A, Chan, Y, Chanock, S J, Chen, C, Chen, Y D I, Colins, F S, Connell, J, Correa, A, Cupples, L A, Davey Smith, G, Davies, G, Dörr, M, Ehret, G, Ellis, S B, Feenstra, B, Feitosa, M F, Ford, I, Fox, C S, Frayling, T M, Friedrich, N, Geller, F, Gillham-Nasenya, I, Gottesman, O, Graff, M, Grodstein, F, Gu, C, Haley, C, Hammond, C J, Harris, S E, Harris, T B, Hastie, N D, Heard-Costa, N L, Heikkilä, K, Hocking, L J, Homuth, G, Hottenga, J J, Huang, J, Huffman, J E, Hysi, P G, Arfan Ikram, M, Ingelsson, E, Joensuu, A, Johansson, A, Jousilahti, P, Jukema, J W, Kähönen, M, Kamatani, Y, Kanoni, S, Kerr, S M, Khan, N M, Koellinger, P, Koistinen, H A, Kooner, M K, Kubo, M, Kuusisto, J, Lahti, J, Launer, L J, Lea, R A, Lehne, B, Lehtimäki, T, Liewald, D C M, Lind, L, Loh, M, Lokki, M L, London, S J, Loomis, S J, Loukola, A, Lu, Y, Lumley, T, Lundqvist, A, Männistö, S, Marques-Vidal, P, Masciullo, C, Matchan, A, Mathias, R A, Matsuda, K, Meigs, J B, Meisinger, C, Meitinger, T, Menni, C, Mentch, F D, Mihailov, E, Milani, L, Montasser, M E, Montgomery, G W, Morrison, A, Myers, R H, Nadukuru, R, Navarro, P, Nelis, M, Nieminen, M S, Nolte, I M, O'Connor, G T, Ogunniyi, A, Padmanabhan, S, Palmas, W R, Pankow, J S, Patarcic, I, Pavani, F, Peyser, P A, Pietilainen, K H, Poulter, N, Prokopenko, I, Ralhan, S, Redmond, P, Rich, S S, Rissanen, H, Robino, A, Rose, L M, Rose, R, Sala, C, Salako, B, Salomaa, V, Sarin, A-P, Saxena, R, Schmidt, H, Scott, L J, Scott, W R, Sennblad, B, Seshadri, S, Sever, P, Shrestha, S, Smith, B H, Smith, J A, Soranzo, N, Sotoodehnia, N, Southam, L, Stanton, A V, Stathopoulou, M G, Strauch, K, Strawbridge, R J, Suderman, M J, Tandon, N, Tang, S T, Taylor, K D, Tayo, B O, Töglhofer, A M, Tomaszewski, M, Tsernikova, N, Tuomilehto, J, Uitterlinden, A G, Vaidya, D, Hylckama Vlieg, A, van Setten, J, Vasankari, T, Vedantam, S, Vlachopoulou, E, Vozzi, D, Vuoksimaa, E, Waldenberger, M, Ware, E B, Wentworth-Shields, W, Whitfield, J B, Wild, S, Willemsen, G, Yajnik, C S, Yao, J, Zaza, G, Zhu, X, Salem, R M, Melbye, M, Bisgaard, H, Samani, N J, Cusi, D, Mackey, D A, Cooper, R S, Froguel, P, Pasterkamp, G, Grant, S F A, Hakonarson, H, Ferrucci, L, Scott, R A, Morris, A D, Palmer, C N A, Dedoussis, G, Deloukas, P, Bertram, L, Lindenberger, U, Berndt, S I, Lindgren, C M, Timpson, N J, Tönjes, A, Munroe, P B, Sorensen, T I A, Rotimi, C N, Arnett, D K, Oldehinkel, A J, Kardia, S L R, Balkau, B, Gambaro, G, Morris, A P, Eriksson, J G, Wright, M J, Martin, N G, Hunt, S C, Starr, J M, Deary, I J, Griffiths, L R, Tiemeier, H, Pirastu, N, Kaprio, J, Wareham, N J, Pérusse, L, Wilson, J G, Girotto, G, Caulfield, M J, Raitakari, O, Boomsma, D I, Gieger, C, van der Harst, P, Hicks, A A, Kraft, P, Sinisalo, J, Knekt, P, Johannesson, M, Magnusson, P K E, Hamsten, A, Schmidt, R, Borecki, I B, Vartiainen, E, Becker, D M, Bharadwaj, D, Mohlke, K L, Boehnke, M, van Duijn, C M, Sanghera, D K, Teumer, A, Zeggini, E, Metspalu, A, Gasparini, P, Ulivi, S, Ober, C, Toniolo, D, Rudan, I, Porteous, D J, Ciullo, M, Spector, T D, Hayward, C, Dupuis, J, Loos, R J F, Wright, A F, Chandak, G R, Vollenweider, P, Shuldiner, A R, Ridker, P M, Rotter, J I, Sattar, N, Gyllensten, U, North, K E, Pirastu, M, Psaty, B M, Weir, D R, Laakso, M, Gudnason, V, Takahashi, A, Chambers, J C, Kooner, J S, Strachan, D P, Campbell, H, Hirschhorn, J N, Perola, M, Polasek, O & Wilson, J F 2015, ' Directional dominance on stature and cognition in diverse human populations ', Nature, vol. 523, no. 7561, pp. 459-462 . https://doi.org/10.1038/nature14618
Nature, 523(7561), 459. Nature Publishing Group
Nature, Vol. 523, No 7561 (2015) pp. 459-462
Joshi, P K, Esko, T, Mattsson, H, Eklund, N, Gandin, I, Nutile, T, Jackson, A U, Schurmann, C, Smith, A V, Zhang, W, Okada, Y, Stančáková, A, Faul, J D, Zhao, W, Bartz, T M, Concas, M P, Franceschini, N, Enroth, S, Vitart, V, Trompet, S, Guo, X, Chasman, D I, O'Connel, J R, Corre, T, Nongmaithem, S S, Chen, Y, Mangino, M, Ruggiero, D, Traglia, M, Farmaki, A-E, Kacprowski, T, Bjonnes, A, van der Spek, A, Wu, Y, Giri, A K, Yanek, L R, Wang, L, Hofer, E, Rietveld, C A, Lataniotis, L, Wood, A R, Hammond, C J, Harris, S E, Hysi, P G, Lehne, B, Menni, C, Wilson, J G, Spector, T D, Weir, D R, Chambers, J C 2015, ' Directional dominance on stature and cognition in diverse human populations ', NATURE, vol. 523, no. 7561, pp. 459-462 . https://doi.org/10.1038/nature14618
Nature, 523, 459-462. Nature Publishing Group
Nature, 523(7561), 459-U176

Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is c

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