Xeno-free cryopreservation of adherent retinal pigmented epithelium yields viable and functional cells in vitro and in vivo

Autor: Britney O. Pennington, Jeffrey K. Bailey, Mohamed A. Faynus, Cassidy Hinman, Mitchell N. Hee, Rory Ritts, Vignesh Nadar, Danhong Zhu, Debbie Mitra, Juan Carlos Martinez-Camarillo, Tai-Chi Lin, Biju B. Thomas, David R. Hinton, Mark S. Humayun, Jane Lebkowski, Lincoln V. Johnson, Dennis O. Clegg

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Abstract Age-related macular degeneration (AMD) is the primary cause of blindness in adults over 60 years of age, and clinical trials are currently assessing the therapeutic potential of retinal pigmented epithelial (RPE) cell monolayers on implantab

Externí odkaz: https://doaj.org/article/f19a0c25861141a083ed1e359e044d22

Cellular models and therapies for age-related macular degeneration

Autor: David L. Forest, Lincoln V. Johnson, Dennis O. Clegg

Publikováno v: Disease Models & Mechanisms, Vol 8, Iss 5, Pp 421-427 (2015)

Age-related macular degeneration (AMD) is a complex neurodegenerative visual disorder that causes profound physical and psychosocial effects. Visual impairment in AMD is caused by the loss of retinal pigmented epithelium (RPE) cells and the light-sen

Externí odkaz: https://doaj.org/article/78fccc2c51694fcb8b937c2177f5fb75

One-Year Follow-Up in a Phase 1/2a Clinical Trial of an Allogeneic RPE Cell Bioengineered Implant for Advanced Dry Age-Related Macular Degeneration

Autor: Debbie Mitra, Sanford Chen, Hani Salehi-Had, April Ingram, Chih-Min Lin, Mohamed A Faynus, Lincoln V. Johnson, Mark S. Humayun, Amir H. Kashani, Narsing A. Rao, Jane Lebkowski, Clement Chan, Dennis O. Clegg, Robert L. Avery, Jeffrey K Bailey, Neal V. Palejwala, Cassidy R. Hinman, Sukriti Mohan, David R. Hinton, Wei Dang, Firas M. Rahhal, Britney O Pennington

Publikováno v: Translational Vision Science & Technology

Purpose To report 1-year follow-up of a phase 1/2a clinical trial testing a composite subretinal implant having polarized human embryonic stem cell (hESC)-derived retinal pigment epithelium (RPE) cells on an ultrathin parylene substrate in subjects w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c59c05560850894233eba1a8aeca28
https://doi.org/10.1167/tvst.10.10.13

Cellular models and therapies for age-related macular degeneration

Autor: Lincoln V. Johnson, David L. Forest, Dennis O. Clegg

Publikováno v: Disease Models & Mechanisms, Vol 8, Iss 5, Pp 421-427 (2015)
Disease Models & Mechanisms
Forest, DL; Johnson, LV; & Clegg, DO. (2015). Cellular models and therapies for age-related macular degeneration. DMM Disease Models and Mechanisms, 8(5), 421-427. doi: 10.1242/dmm.017236. UC Santa Barbara: Retrieved from: http://www.escholarship.org/uc/item/11s2w3sw
Disease models & mechanisms, vol 8, iss 5

Age-related macular degeneration (AMD) is a complex neurodegenerative visual disorder that causes profound physical and psychosocial effects. Visual impairment in AMD is caused by the loss of retinal pigmented epithelium (RPE) cells and the light-sen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40b8a92c657c6483fd9aafe417ea636
http://dmm.biologists.org/content/8/5/421

Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins

Autor: David E. Buchholz, Lincoln V. Johnson, Teisha J. Rowland, Sherry T. Hikita, Alison J. Blaschke, Dennis O. Clegg

Publikováno v: Journal of Tissue Engineering and Regenerative Medicine. 7:642-653

A potential application of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) is the generation of retinal pigmented epithelium (RPE) to treat age-related macular degeneration (AMD), a common but incurable retinal disease.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a2b24900fc54e8250135d292fc1f27d
https://doi.org/10.1002/term.1458