Zobrazeno 1 - 10
of 305
pro vyhledávání: '"Lincoln Stein"'
Autor:
Lauren Hughes, Kirsten Farncombe, Michelle Brazas, Melyssa Aronson, Kathleen Bell, Brandon Chan, Andrea Eisen, Harriet Feilotter, Bailey Gallinger, Jordan Lerner-Ellis, David Malkin, Ellen MacDougall, Steven Narod, Karen Panabaker, Trevor Pugh, Sarah Sawyer, Alison Rusnak, Andrea Vaags, Laszlo Radvanyi, Lincoln Stein, Raymond Kim
Publikováno v:
Genetics in Medicine Open, Vol 1, Iss 1, Pp 100073- (2023)
Externí odkaz:
https://doaj.org/article/c38002f5ac4340b7a33c4bab75bdf9a1
Autor:
Shimin Shuai, PCAWG Drivers and Functional Interpretation Working Group, Steven Gallinger, Lincoln Stein, PCAWG Consortium
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding
Externí odkaz:
https://doaj.org/article/142b65513ccf441182a79c2cf78b29df
Autor:
Irina Kalatskaya, Quang M. Trinh, Melanie Spears, John D. McPherson, John M. S. Bartlett, Lincoln Stein
Publikováno v:
Genome Medicine, Vol 9, Iss 1, Pp 1-18 (2017)
Abstract Background A key step in cancer genome analysis is the identification of somatic mutations in the tumor. This is typically done by comparing the genome of the tumor to the reference genome sequence derived from a normal tissue taken from the
Externí odkaz:
https://doaj.org/article/3874531847174a59b6e298ac61eafc3b
Publikováno v:
F1000Research, Vol 8 (2019)
The precision medicine paradigm is centered on therapies targeted to particular molecular entities that will elicit an anticipated and controlled therapeutic response. However, genetic alterations in the drug targets themselves or in genes whose prod
Externí odkaz:
https://doaj.org/article/785f588ef95741b3ae9f3389bc0d9b80
Autor:
Antonio Fabregat, Florian Korninger, Guilherme Viteri, Konstantinos Sidiropoulos, Pablo Marin-Garcia, Peipei Ping, Guanming Wu, Lincoln Stein, Peter D'Eustachio, Henning Hermjakob
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 1, p e1005968 (2018)
Reactome is a free, open-source, open-data, curated and peer-reviewed knowledgebase of biomolecular pathways. One of its main priorities is to provide easy and efficient access to its high quality curated data. At present, biological pathway database
Externí odkaz:
https://doaj.org/article/8e5f59756057424c9d613f9c230eeff0
Autor:
Brian D. O'Connor, Denis Yuen, Vincent Chung, Andrew G. Duncan, Xiang Kun Liu, Janice Patricia, Benedict Paten, Lincoln Stein, Vincent Ferretti
Publikováno v:
F1000Research, Vol 6 (2017)
As genomic datasets continue to grow, the feasibility of downloading data to a local organization and running analysis on a traditional compute environment is becoming increasingly problematic. Current large-scale projects, such as the ICGC PanCancer
Externí odkaz:
https://doaj.org/article/dde76a7db51b43209a4b37b03553209b
Autor:
Lincoln Stein, Peter D'Eustachio, Henning Hermjakob, David Croft, Guanming Wu, Karen Rothfels, Robin Haw, Marija Milacic
Publikováno v:
Cancers, Vol 4, Iss 4, Pp 1180-1211 (2012)
Reactome describes biological pathways as chemical reactions that closely mirror the actual physical interactions that occur in the cell. Recent extensions of our data model accommodate the annotation of cancer and other disease processes. First, we
Externí odkaz:
https://doaj.org/article/d6fd5ab8aa194249b0b9025361bf48ab
Publikováno v:
F1000Research, Vol 3 (2014)
High-throughput experiments are routinely performed in modern biological studies. However, extracting meaningful results from massive experimental data sets is a challenging task for biologists. Projecting data onto pathway and network contexts is a
Externí odkaz:
https://doaj.org/article/40ebb42e7d9e4a81aa3e00d5fedf1808
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97997 (2014)
Studies indicate that high-grade serous ovarian carcinoma (HGSOC), the most common epithelial ovarian carcinoma histotype, originates from the fallopian tube epithelium (FTE). Risk factors for this cancer include reproductive parameters associated wi
Externí odkaz:
https://doaj.org/article/0ec0db3de6b6476abe690f08c4d47e3e
Autor:
Nicolas Nègre, Christopher D Brown, Parantu K Shah, Pouya Kheradpour, Carolyn A Morrison, Jorja G Henikoff, Xin Feng, Kami Ahmad, Steven Russell, Robert A H White, Lincoln Stein, Steven Henikoff, Manolis Kellis, Kevin P White
Publikováno v:
PLoS Genetics, Vol 6, Iss 1, p e1000814 (2010)
Insulators are DNA sequences that control the interactions among genomic regulatory elements and act as chromatin boundaries. A thorough understanding of their location and function is necessary to address the complexities of metazoan gene regulation
Externí odkaz:
https://doaj.org/article/8ba6505ad30c4a3da2eeb57c9ac07ec0