Výsledky vyhledávání - "Lincoln H. Wilkins"

Potential Value of Changes in Cell Markers in Organotypic Hippocampal Cultures Associated With Chronic EtOH Exposure and Withdrawal: Comparison with NMDA-Induced Changes

Autor: John A. Blanchard, Lincoln H. Wilkins, John M. Littleton, Robert C. Holley, Elton R. Chambers, Mark A. Prendergast

Publikováno v: Alcoholism: Clinical and Experimental Research. 30:1768-1780

Background: Previous studies have shown that withdrawal from ethanol (EtOH) exposure induces neuronal damage, as indicated by propidium iodide (PI) uptake, in organotypic hippocampal slice cultures. This is prevented by MK801, suggesting that damage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8691cc361b92dfcc9a913277fe7ba95
https://doi.org/10.1111/j.1530-0277.2006.00210.x

Zobrazit plný text záznamu

Alcohol-Induced Neurodegeneration: When, Where and Why?

Autor: Roberta J. Pentney, Edward J. Neafsey, Antonio Noronha, Jian Zou, Fulton T. Crews, John M. Littleton, Lawrence D. Snell, Lincoln H. Wilkins, Boris Tabakoff, Cynthia A. Dlugos, Michael A. Collins

Publikováno v: Alcoholism: Clinical & Experimental Research. 28:350-364

This manuscript reviews the proceedings of a symposium organized by Drs. Antonio Noronha and Fulton Crews presented at the 2003 Research Society on Alcoholism meeting. The purpose of the symposium was to examine recent findings on when alcohol induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ae6fab380a1e2998d42d33d1f6f53ec
https://doi.org/10.1097/01.alc.0000113416.65546.01

Zobrazit plný text záznamu

Pharmacology, distribution and development of muscarinic acetylcholine receptor subtypes in the optic tectum of Rana pipiens

Autor: Linda P. Dwoskin, Lincoln H. Wilkins, Elizabeth A. Debski, Christopher M. Butt, James R. Pauly

Publikováno v: Neuroscience. 104:161-179

Visually evoked behaviors mediated by the frog optic tectum require cholinergic activity, but the receptor subtypes through which acetylcholine acts are not yet identified. Using quantitative autoradiography and scintillation spectrometry, we examine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ed043a7dc28fe01587a0da93c5772a
https://doi.org/10.1016/s0306-4522(01)00048-3

Zobrazit plný text záznamu

A genetic comparison of behavioral actions of ethanol and nicotine in the mirrored chamber

Autor: Allan C. Collins, Wu Cao, Lincoln H. Wilkins, Trent Burkholder

Publikováno v: Pharmacology Biochemistry and Behavior. 45:803-809

Human alcoholics are almost invariably heavy users of tobacco, perhaps because both ethanol and nicotine may have anxiolytic activity. However, studies in humans have not uniformly detected anxiolytic effects because significant individual difference

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30184571357a5b7d25e16f5a3ba3d654
https://doi.org/10.1016/0091-3057(93)90124-c

Zobrazit plný text záznamu

N-n-alkylnicotinium analogs, a novel class of antagonists at alpha 4 beta 2* nicotinic acetylcholine receptors: inhibition of S(-)-nicotine-evoked 86Rb+ efflux from rat thalamic synaptosomes

Autor: Linda P. Dwoskin, Joshua T. Ayers, Dennis K. Miller, Lincoln H. Wilkins, Peter A. Crooks

Publikováno v: The AAPS journal. 7(4)

Pyridine N-n-alkylation of S(-)-nicotine (NIC) affords N-n-alkylnicotinium analogs, previously shown to competitively inhibit [(3)H]NIC binding and interact with alpha4beta2* nicotinic receptors (nAChRs). The present study determined the ability of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b481cb36478bb26631ecc39e467bcc
https://pubmed.ncbi.nlm.nih.gov/16594645

Zobrazit plný text záznamu

Introduction of unsaturation into the N-n-alkyl chain of the nicotinic receptor antagonists, NONI and NDNI: effect on affinity and selectivity

Autor: Rui Xu, Linda P. Dwoskin, Jun Zhu, Peter A. Crooks, Sangeetha P. Sumithran, Lincoln H. Wilkins, Agripina G. Deaciuc

Publikováno v: The AAPS journal. 7(1)

N-n-octylnicotinium iodide (NONI) and N-n-decylnicotinium iodide (NDNI) are selective nicotinic receptor (nAChR) antagonists mediating nicotine-evoked striatal dopamine (DA) release, and inhibiting [3H]nicotine binding, respectively. This study evalu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c98d6525a34e0f19ede8619c2c0e2e
https://pubmed.ncbi.nlm.nih.gov/16146341

Zobrazit plný text záznamu

Opposing effects of ethanol and nicotine on hippocampal calbindin-D28k expression

Autor: Patrick J. Mulholland, Rachel L. Self, Lincoln H. Wilkins, John M. Littleton, Mark A. Prendergast, Robert C. Holley, Barton R. Harris, John A. Blanchard

Publikováno v: Alcohol (Fayetteville, N.Y.). 31(1-2)

Long-term ethanol exposure produces multiple neuroadaptations that likely contribute to dysregulation of Ca2+ balance and neurotoxicity during ethanol withdrawal. Conversely, nicotine exposure may reduce the neurotoxic consequences of Ca2+ dysregulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca049d78492c8ee1dbfce1aca7cbacf
https://pubmed.ncbi.nlm.nih.gov/14615005

Zobrazit plný text záznamu

Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release

Autor: Linda P. Dwoskin, Vladimir P. Grinevich, Peter A. Crooks, Lincoln H. Wilkins, David D. Allen, Joshua T. Ayers, A. Gabriela Deaciuc, Sangeetha P. Sumithran, Rui Xu

Publikováno v: Bioorganicmedicinal chemistry letters. 14(8)

N-n-Alkylation of nicotine converts it from an agonist into an antagonist at neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. Conformationally restricted analogues exhibit both high affinity and selectivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4602da638f9a557e64cbeb358d0b6dd0
https://pubmed.ncbi.nlm.nih.gov/15050618

Zobrazit plný text záznamu

N-n-alkylnicotinium analogs, a novel class of nicotinic receptor antagonists: interaction with alpha4beta2* and alpha7* neuronal nicotinic receptors

Autor: Peter A. Crooks, Joshua T. Ayers, Vladimir P. Grinevich, Lincoln H. Wilkins, Linda P. Dwoskin

Publikováno v: The Journal of pharmacology and experimental therapeutics. 304(1)

The current study demonstrates that N-n-alkylnicotinium analogs with increasing n-alkyl chain lengths from 1 to 12 carbons have varying affinity (Ki = 90 nM-20 microM) for S-(-)-[3H]nicotine binding sites in rat striatal membranes. A linear relations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b796056e322e58cde5f1ebc4e74aabe7
https://pubmed.ncbi.nlm.nih.gov/12490617

Zobrazit plný text záznamu

Effects of prolonged nicotinic ligand exposure on function of heterologously expressed, human alpha4beta2- and alpha4beta4-nicotinic acetylcholine receptors

Autor: Cynthia L. Gentry, Lincoln H. Wilkins, Ronald J. Lukas

Publikováno v: The Journal of pharmacology and experimental therapeutics. 304(1)

Effects of prolonged nicotinic ligand exposure on the function of human alpha4beta2- and alpha4beta4-nicotinic acetylcholine receptor (nAChR) subtypes were studied using receptors heterologously expressed in SH-EP1 human epithelial cells. Magnitudes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419c5037654f3b03f669065ff1d57e0c
https://pubmed.ncbi.nlm.nih.gov/12490593

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání