Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Linc Chen"'
Publikováno v:
Molecular Pharmaceutics. 19:1505-1514
Administration of highly concentrated monoclonal antibodies (mAbs) through injection is often not possible as the viscosity can be readily above 50 mPa·s when the concentration exceeds 150 mg/mL. Besides, highly concentrated mAb solutions always exh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a4d503ca309c8ec3a8b090769dde23
https://doi.org/10.1021/acs.molpharmaceut.2c00039
https://doi.org/10.1021/acs.molpharmaceut.2c00039
Publikováno v:
Molecular pharmaceutics. 19(8)
Drug-polymer interactions are of great importance in amorphous solid dispersion (ASD) formulation for both dissolution performance and physical stability considerations. In this work, three felodipine ASD systems with drug loading ranging from 5 to 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2d3dd0611df322d17346fdf15b27c4
https://pubmed.ncbi.nlm.nih.gov/35759395
https://pubmed.ncbi.nlm.nih.gov/35759395
Autor:
Huangliang Zheng, Michael Moehwald, Linc Chen, Shirui Mao, Yuyang Zhang, Xiaoran Li, Chenhong Guo, Moritz Beck-Broichsitter, Jiaqi Li, Ying Sun, Lu Qin, Jian Su
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 143:70-79
Controlled drug delivery to the lungs is promising with plentiful advantages over current rapid release products. However, alveolar macrophage clearance has severely hindered the application of inhaled controlled release preparations. The objective o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb7015dc572d667230403acddabb40f
https://doi.org/10.1016/j.ejpb.2019.08.017
https://doi.org/10.1016/j.ejpb.2019.08.017
Autor:
Lan Zhang, Uwe Muenster, Yuyang Zhang, Jiaqi Li, Lu Qin, Linc Chen, Linglong Yang, Huangliang Zheng, Shirui Mao, Linlin Fan, Xiaofei Zhang, En-Yu Xu, Moritz Beck-Broichsitter
Publikováno v:
Acta Biomaterialia. 96:505-516
Large porous particles (LPPs) are well-known vehicles for drug delivery to the lungs. However, it remains uncertain whether or to which extent the in vitro drug release behavior of LPPs can be predictive of their in vivo performance (e.g., systemic e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ca5860c0d2a89b975d2049d0055290
https://doi.org/10.1016/j.actbio.2019.06.056
https://doi.org/10.1016/j.actbio.2019.06.056
Publikováno v:
Acta biomaterialia. 123
Polyethylene glycol (PEG) modification is one of the promising approaches to overcome both mucus and alveolar macrophage uptake barriers in the deep lung for sustained therapy of pulmonary diseases such as asthma. To investigate the feasibility of us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c310e4466cf357f2b80c355a7883a2f1
https://pubmed.ncbi.nlm.nih.gov/33454386
https://pubmed.ncbi.nlm.nih.gov/33454386
Autor:
Jian Su, Uwe Muenster, Ying Sun, Lan Zhang, Linc Chen, Lu Qin, Xiaofei Zhang, Jiaqi Li, Moritz Beck-Broichsitter, Shirui Mao
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 155
Sustained drug delivery is considered as an effective strategy to improve the treatment of local lung diseases. In this context, inhalation administration of large porous microparticles (LPPs) represents promising prospects. However, one major challe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976bc4b6c540c930f0b5db185168c10b
https://pubmed.ncbi.nlm.nih.gov/32853695
https://pubmed.ncbi.nlm.nih.gov/32853695
Autor:
Shan Wang, Peter Serno, Wouter Tonnis, Huijun Chen, Feng Qian, Linc Chen, Yipshu Pui, Yuejie Chen
Publikováno v:
Molecular Pharmaceutics. 16:205-213
We investigated the drug-polymer interactions in nonaqueous and aqueous environments between a poorly water-soluble drug, BAY1161909 (909), and two commonly used polymers in amorphous solid dispersions, i.e., PVP and HPMC-AS. In an nonaqueous state,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f68fce757d5eb1bd142684480dd32b
https://doi.org/10.1021/acs.molpharmaceut.8b00947
https://doi.org/10.1021/acs.molpharmaceut.8b00947
Autor:
Huijun Chen, Wouter Tonnis, Linc Chen, Shan Wang, Peter Serno, Stefan Bracht, Feng Qian, Chengyu Liu, Yipshu Pui, Yuejie Chen
Publikováno v:
Molecular Pharmaceutics. 15:2754-2763
Amorphous solid dispersion (ASD) is one of the most versatile supersaturating drug delivery systems to improve the dissolution rate and oral bioavailability of poorly water-soluble drugs. PVP based ASD formulation of nimodipine (NMD) has been markete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e9c35638434e55cb18e1930f31b036
https://doi.org/10.1021/acs.molpharmaceut.8b00253
https://doi.org/10.1021/acs.molpharmaceut.8b00253
Autor:
Linc Chen, Shan Wang, Wouter F. Tonnis, Peter Serno, Feng Qian, Huijun Chen, Yuejie Chen, Yipshu Pui
Publikováno v:
Molecular Pharmaceutics. 16:1787-1787
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18020fa15b385ac5cea619494b36f517
https://doi.org/10.1021/acs.molpharmaceut.9b00229
https://doi.org/10.1021/acs.molpharmaceut.9b00229
Publikováno v:
Acta crystallographica. Section D, Biological crystallography. 65(Pt 11)
Cholesterol oxidase is a flavoenzyme that catalyzes the oxidation and isomerization of 3beta-hydroxysteroids. Structural and mutagenesis studies have shown that Asn485 plays a key role in substrate oxidation. The side chain makes an NH...pi interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a5e8cfdbf20976b9e7f4398bcf31e6
https://pubmed.ncbi.nlm.nih.gov/19923719
https://pubmed.ncbi.nlm.nih.gov/19923719