Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Linbei Wu"'
Autor:
Li Zhong, Zongqi Wang, Daxin Wang, Zhe Wang, Yuka A. Martens, Linbei Wu, Ying Xu, Kai Wang, Jianguo Li, Ruizhi Huang, Dan Can, Huaxi Xu, Guojun Bu, Xiao-Fen Chen
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-12 (2018)
Abstract Background TREM2 is an innate immune receptor specifically expressed in microglia. Coding variations in TREM2 have been reported to increase the risk for Alzheimer’s disease (AD) and other neurodegenerative diseases. While multiple studies
Externí odkaz:
https://doaj.org/article/f413ba11b8e2416fb1992f25f45c6001
Autor:
Guojun Bu, Li Zhong, Chia Chen Liu, Huaxi Xu, Lin Jia, Linbei Wu, Daxin Wang, Zongqi Wang, Zhe Wang, Xinxiu Li, Meghan M. Painter, Yun-wu Zhang, Xiao Fen Chen, Tingting Wang, Chunyan Liao, Yuka Atagi, Honghua Zheng, Ruizhi Huang, John D. Fryer
Publikováno v:
Journal of Experimental Medicine. 214:597-607
Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor expressed in microglia in the brain. A soluble form of TREM2 (sTREM2) derived from proteolytic cleavage of the cell surface receptor is increased in the preclinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2265c555f55c8c5cda643c253b569d5c
https://doi.org/10.1084/jem.20160844
https://doi.org/10.1084/jem.20160844
Autor:
Ying Xu, Xiao Fen Chen, Guojun Bu, Huaxi Xu, Kai Wang, Yuka A. Martens, Li Zhong, Linbei Wu, Daxin Wang, Ruizhi Huang, Zhe Wang, Dan Can, Jianguo Li, Zongqi Wang
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-12 (2018)
Molecular Neurodegeneration
Molecular Neurodegeneration
Background TREM2 is an innate immune receptor specifically expressed in microglia. Coding variations in TREM2 have been reported to increase the risk for Alzheimer’s disease (AD) and other neurodegenerative diseases. While multiple studies support
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1ab601841c55c76f01b97f622902f8
https://doi.org/10.1186/s13024-018-0247-7
https://doi.org/10.1186/s13024-018-0247-7
Autor:
Zhong, Li, Zongqi Wang, Daxin Wang, Wang, Zhe, Martens, Yuka, Linbei Wu, Xu, Ying, Wang, Kai, Jianguo Li, Ruizhi Huang, Can, Dan, Huaxi Xu, Guojun Bu, Chen, Xiao-Fen
Figure S1. Oligomeric Aβ1–42 specifically binds to TREM2. Figure S2. Oligomeric Aβ1–42 specifically activates TREM2 reporter cells. Figure S3. The number of microglia clustered around Aβ is decreased in Trem2-KO mice. (PDF 1369 kb)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00967e0adacdb0d6288333817ce87c89
