Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Linas Mazutis"'
Autor:
Justina Zvirblyte, Juozas Nainys, Simonas Juzenas, Karolis Goda, Raimonda Kubiliute, Darius Dasevicius, Marius Kincius, Albertas Ulys, Sonata Jarmalaite, Linas Mazutis
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Clear cell renal cell carcinoma (ccRCC) is the most prevalent form of renal cancer, accounting for over 75% of cases. The asymptomatic nature of the disease contributes to late-stage diagnoses and poor survival. Highly vascularized and immun
Externí odkaz:
https://doaj.org/article/53bd88279a69465cae99e3ad5154a85d
Autor:
Álvaro Quintanal-Villalonga, Joseph M. Chan, Ignas Masilionis, Vianne Ran Gao, Yubin Xie, Viola Allaj, Andrew Chow, John T. Poirier, Dana Pe’er, Charles M. Rudin, Linas Mazutis
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101776- (2022)
Summary: We report a protocol for obtaining high-quality single-cell transcriptomics data from human lung biospecimens acquired from core needle biopsies, fine-needle aspirates, surgical resection, and pleural effusions. The protocol relies upon the
Externí odkaz:
https://doaj.org/article/237874114b8a404ab1b404381e5e804b
Autor:
Justina Rutkauskaite, Simon Berger, Stavros Stavrakis, Oliver Dressler, John Heyman, Xavier Casadevall i Solvas, Andrew deMello, Linas Mazutis
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104515- (2022)
Summary: High-throughput screening and enrichment of antibody-producing cells have many important applications. Herein, we present a droplet microfluidic approach for high-throughput screening and sorting of antibody-secreting cells using a Förster
Externí odkaz:
https://doaj.org/article/e5ef9d1f57f34379a24c7ec079b917c6
Autor:
Xiao-Chuan Cai, Tuo Zhang, Eui-jun Kim, Ming Jiang, Ke Wang, Junyi Wang, Shi Chen, Nawei Zhang, Hong Wu, Fengling Li, Carlo C dela Seña, Hong Zeng, Victor Vivcharuk, Xiang Niu, Weihong Zheng, Jonghan P Lee, Yuling Chen, Dalia Barsyte, Magda Szewczyk, Taraneh Hajian, Glorymar Ibáñez, Aiping Dong, Ludmila Dombrovski, Zhenyu Zhang, Haiteng Deng, Jinrong Min, Cheryl H Arrowsmith, Linas Mazutis, Lei Shi, Masoud Vedadi, Peter J Brown, Jenny Xiang, Li-Xuan Qin, Wei Xu, Minkui Luo
Publikováno v:
eLife, Vol 9 (2020)
Externí odkaz:
https://doaj.org/article/529e0f4d945f41b89585de51965cfd50
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11571 (2021)
Protein Carbonic Anhydrase IX (CA IX), which is expressed in various hypoxic solid tumors in order to maintain proper pH, is also related to cancer cell adhesion, invasion, and metastasis processes. Here, we investigated whether CA IX inhibition by a
Externí odkaz:
https://doaj.org/article/579aaccde4884c30b746cc687a0197b9
Autor:
Xiao-Chuan Cai, Tuo Zhang, Eui-jun Kim, Ming Jiang, Ke Wang, Junyi Wang, Shi Chen, Nawei Zhang, Hong Wu, Fengling Li, Carlo C dela Seña, Hong Zeng, Victor Vivcharuk, Xiang Niu, Weihong Zheng, Jonghan P Lee, Yuling Chen, Dalia Barsyte, Magda Szewczyk, Taraneh Hajian, Glorymar Ibáñez, Aiping Dong, Ludmila Dombrovski, Zhenyu Zhang, Haiteng Deng, Jinrong Min, Cheryl H Arrowsmith, Linas Mazutis, Lei Shi, Masoud Vedadi, Peter J Brown, Jenny Xiang, Li-Xuan Qin, Wei Xu, Minkui Luo
Publikováno v:
eLife, Vol 8 (2019)
CARM1 is a cancer-relevant protein arginine methyltransferase that regulates many aspects of transcription. Its pharmacological inhibition is a promising anti-cancer strategy. Here SKI-73 (6a in this work) is presented as a CARM1 chemical probe with
Externí odkaz:
https://doaj.org/article/e2cc04f7ee7c46688f502928eba49e93
Autor:
Greta Zubaite, Karolis Simutis, Robertas Galinis, Valdemaras Milkus, Vaidotas Kiseliovas, Linas Mazutis
Publikováno v:
Micromachines, Vol 8, Iss 2, p 62 (2017)
Protein expression in vitro has broad applications in directed evolution, synthetic biology, proteomics and drug screening. However, most of the in vitro expression systems rely on relatively high DNA template concentrations to obtain sufficient amou
Externí odkaz:
https://doaj.org/article/bf737a10ee0b4ab5accf4da5f3f7e5fa
Autor:
Ariella Glasner, Samuel A. Rose, Roshan Sharma, Herman Gudjonson, Tinyi Chu, Jesse A. Green, Sham Rampersaud, Izabella K. Valdez, Emma S. Andretta, Bahawar S. Dhillon, Michail Schizas, Stanislav Dikiy, Alejandra Mendoza, Wei Hu, Zhong-Min Wang, Ojasvi Chaudhary, Tianhao Xu, Linas Mazutis, Gabrielle Rizzuto, Alvaro Quintanal-Villalonga, Parvathy Manoj, Elisa de Stanchina, Charles M. Rudin, Dana Pe’er, Alexander Y. Rudensky
Publikováno v:
Nature Immunology. 24:1020-1035
While regulatory T (Treg) cells are traditionally viewed as professional suppressors of antigen presenting cells and effector T cells in both autoimmunity and cancer, recent findings of distinct Treg cell functions in tissue maintenance suggest that
Autor:
Joseph M. Chan, Samir Zaidi, Jillian R. Love, Jimmy L. Zhao, Manu Setty, Kristine M. Wadosky, Anuradha Gopalan, Zi-Ning Choo, Sitara Persad, Jungmin Choi, Justin LaClair, Kayla E. Lawrence, Ojasvi Chaudhary, Tianhao Xu, Ignas Masilionis, Irina Linkov, Shangqian Wang, Cindy Lee, Afsar Barlas, Michael J. Morris, Linas Mazutis, Ronan Chaligne, Yu Chen, David W. Goodrich, Wouter R. Karthaus, Dana Pe’er, Charles L. Sawyers
Publikováno v:
Science
Drug resistance in cancer is often linked to changes in tumor cell state or lineage, but the molecular mechanisms driving this plasticity remain unclear. Using murine organoid and genetically engineered mouse models, we investigated the causes of lin
Autor:
Cassandra Burdziak, Direna Alonso-Curbelo, Thomas Walle, José Reyes, Francisco M. Barriga, Doron Haviv, Yubin Xie, Zhen Zhao, Chujun Julia Zhao, Hsuan-An Chen, Ojasvi Chaudhary, Ignas Masilionis, Zi-Ning Choo, Vianne Gao, Wei Luan, Alexandra Wuest, Yu-Jui Ho, Yuhong Wei, Daniela F. Quail, Richard Koche, Linas Mazutis, Ronan Chaligné, Tal Nawy, Scott W. Lowe, Dana Pe’er
Publikováno v:
Science. 380
The response to tumor-initiating inflammatory and genetic insults can vary among morphologically indistinguishable cells, suggesting as yet uncharacterized roles for epigenetic plasticity during early neoplasia. To investigate the origins and impact