Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Linah Mahmoud"'
Autor:
Zeyad Muazzen, Walid Moghrabi, Tala Bakheet, Linah Mahmoud, Maher Al-Saif, Khalid S. A. Khabar, Edward G. Hitti
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Glucocorticoids (GC) like dexamethasone (Dex) are potent anti-inflammatory agents with diverse cellular functions including the potentiation of the activity of AU-rich elements (AREs). AREs are cis-acting instability sequence elements locate
Externí odkaz:
https://doaj.org/article/41f8c1bd4da6413b9fafd53175f244c2
Autor:
Qamraa H. Al‐Qahtani, Walid N. Moghrabi, Suhad Al‐Yahya, Latifa Al‐Haj, Maher Al‐Saif, Linah Mahmoud, Falah Al‐Mohanna, Norah Al‐Souhibani, Ayodele Alaiya, Edward Hitti, Khalid S. A. Khabar
Publikováno v:
Molecular Oncology, Vol 15, Iss 8, Pp 2120-2139 (2021)
Dysfunctions in post‐transcriptional control are observed in cancer and chronic inflammatory diseases. Here, we employed a kinome inhibitor library (n = 378) in a reporter system selective for 3′‐untranslated region–AU‐rich elements (ARE).
Externí odkaz:
https://doaj.org/article/9b16b262c2074fbf8d05f478d8b4d7df
Autor:
Linah Mahmoud, Alaa S. Abdulkarim, Shaima Kutbi, Walid Moghrabi, Sulaiman Altwijri, Khalid S. A. Khabar, Edward G. Hitti
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Cyclic-di-AMP (c-di-AMP) is a bacterial second messenger that is produced by intracellular bacterial pathogens in mammalian host macrophages. Previous reports have shown that c-di-AMP is recognized by intracellular pattern recognition receptors of th
Externí odkaz:
https://doaj.org/article/5399ffcf3b0a4fd5ab22a050c0a099b7
Autor:
Ayodele Alaiya, Norah Al-Souhibani, Latifa Al-Haj, Qamraa H. Al‐Qahtani, Falah Al-Mohanna, Edward Hitti, Suhad Al-Yahya, Walid Moghrabi, Maher Al-Saif, Khalid S.A. Khabar, Linah Mahmoud
Publikováno v:
Molecular Oncology, Vol 15, Iss 8, Pp 2120-2139 (2021)
Molecular Oncology
Molecular Oncology
Dysfunctions in post‐transcriptional control are observed in cancer and chronic inflammatory diseases. Here, we employed a kinome inhibitor library (n = 378) in a reporter system selective for 3′‐untranslated region–AU‐rich elements (ARE).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db036870787f3266b37aae25edb28f2
https://doaj.org/article/9b16b262c2074fbf8d05f478d8b4d7df
https://doaj.org/article/9b16b262c2074fbf8d05f478d8b4d7df
Publikováno v:
RNA Biology
AU-rich elements (AREs) are cis-acting instability and translation inhibition elements that are present in the 3ʹUTR of most inducible inflammatory mRNAs such as TNF and Cxcl2. mRNAs that contain AREs are, by default, repressed and only transiently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c8c8110d5ac98f56435c9c734cb59fe
https://doi.org/10.1080/15476286.2019.1572437
https://doi.org/10.1080/15476286.2019.1572437
Autor:
Sulaiman Altwijri, Linah Mahmoud, Shaima Kutbi, Alaa S. Abdulkarim, Khalid S.A. Khabar, Walid Moghrabi, Edward Hitti
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Frontiers in Immunology
Frontiers in Immunology
Cyclic-di-AMP (c-di-AMP) is a bacterial second messenger that is produced by intracellular bacterial pathogens in mammalian host macrophages. Previous reports have shown that c-di-AMP is recognized by intracellular pattern recognition receptors of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49831e8c2879ee874c3a02fddfbfe790
https://doi.org/10.3389/fimmu.2019.03050
https://doi.org/10.3389/fimmu.2019.03050
Autor:
Arjumand S. Warsy, Linah Mahmoud, Maher Al-Saif, Edward Hitti, Khalid S.A. Khabar, Fatma Al-Enezi
Publikováno v:
RNA Biology. 11:124-133
The mRNAs of most inflammatory mediators are short-lived due to AU-rich elements (AREs) in their 3′-untranslated regions. AREs ensure a low basal level of expression during homeostasis and a transient nature of expression during the inflammatory re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0b688a495d55a5e169bea86b02e832
https://doi.org/10.4161/rna.27863
https://doi.org/10.4161/rna.27863
Autor:
Latifa Al-Haj, Irina G. Luzina, Khalid Alkattan, Luke J. Janssen, Eid Almutairy, Mohammed Khalid, Brian F. Meyer, Azizah Al-Enazi, Abeer Abdelsayed, Muzamil Chisti, Faiga Ahmad Imtiaz, Sergei P. Atamas, Futwan Al-Mohanna, Ihab Weheba, Khalid S.A. Khabar, Khushnooda Ramzan, Shamayel Mohammed, Ayodele Alaiya, Linah Mahmoud, Abdullah Mobeireek, Soad Saleh, Somaya Al Qattan, Maher Al-Saif, Mohammed Al-Owain, Kate S. Collison, Jeffrey D. Hasday, Abdullah M. AlJebreen, Walter Conca
Publikováno v:
European Respiratory Journal. 54:1802041
BackgroundPulmonary fibrosis is one of the leading indications for lung transplantation. The disease, which is of unknown aetiology, can be progressive, resulting in distortion of the extracellular matrix (ECM), inflammation, fibrosis and eventual de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9fd05f9c9205ad54feddaa0384cf78f
https://doi.org/10.1183/13993003.02041-2018
https://doi.org/10.1183/13993003.02041-2018
Autor:
Paul R. Bohjanen, Irina Vlasova-St. Louis, Linah Mahmoud, Anason S. Halees, Maher Al-Saif, Daniel Beisang, Edward Hitti, Khalid S.A. Khabar
Publikováno v:
RNA Biology. 8:681-691
Unlike AU-rich elements (ARes) that are largely present in the 3′UTRs of many unstable mammalian mRNAs, the function and abundance of GU-rich elements (GRes) are poorly understood. We performed a genome-wide analysis and found that at least 5% of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9555836a6b4d7341f27db7663c6f13d0
https://doi.org/10.4161/rna.8.4.16283
https://doi.org/10.4161/rna.8.4.16283
Autor:
Khalid S.A. Khabar, Maher Al-Saif, Haitham M. Amer, Linah Mahmoud, Fahad N. Almajhdi, Mustafa Sheikh
Publikováno v:
Journal of Virology
Interferon (IFN) is produced and secreted by various mammalian cell lines when they are infected by viruses, and it plays a regulatory role in innate immunity against viral infections. It also represents a significant therapeutic molecule in a number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e13befb3c6b3c6512502028e2e02e99
https://europepmc.org/articles/PMC3165742/
https://europepmc.org/articles/PMC3165742/
