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of 12
pro vyhledávání: '"Lina Thorvaldson"'
Autor:
Zhengkang Luo, Charlotte Soläng, Mariela Mejia‐Cordova, Lina Thorvaldson, Martin Blixt, Stellan Sandler, Kailash Singh
Publikováno v:
FASEB BioAdvances, Vol 1, Iss 9, Pp 538-549 (2019)
Abstract In type 1 diabetes (T1D), the insulin‐producing β cells are destructed by immune mechanisms. It has been hypothesized that the very first immune response in T1D onset comes from innate immune cells, which further activates the adaptive im
Externí odkaz:
https://doaj.org/article/ca542103895b4ac4b1d72f4ff2bf056e
Publikováno v:
Journal of visualized experiments : JoVE. (144)
Our immune system consists of a number and variety of immune cells including regulatory T cells (Treg) cells. Treg cells can be divided into two subsets, thymic derived Treg (tTreg) cells and peripherally induced Treg (pTreg) cells. They are present
Autor:
Lina Thorvaldson, Stellan Sandler
Publikováno v:
Transplant Immunology. 20:186-194
Many experimental islet studies compare the effect of allogeneic transplantations with either syngeneically transplanted or sham-operated animals. Presently we examined multiple "control" treatments to be able to distinguish effects by the operating
Autor:
Kailash Singh, Marcus Lundberg, Erik Kadesjo, Daniel Espes, Per-Ola Carlsson, Lina Thorvaldson, Julia Lindroos, Marcus Hjort, Stellan Sandler
Publikováno v:
Scientific Reports
The anti-inflammatory cytokine IL-35 is produced by regulatory T (Treg) cells to suppress autoimmune and inflammatory responses. The role of IL-35 in type 1 diabetes (T1D) remains to be answered. To elucidate this, we investigated the kinetics of Tre
Publikováno v:
Scientific Reports
Regulatory T (Treg) cells are characterized by the expression of CD4, CD25 and the intracellular Foxp3. However, these markers do not indicate whether Treg cells are thymic derived Treg (tTreg) cells or peripherally induced Treg (pTreg) cells. Recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f220bc5f717a0e78e51c67f24a7c69
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-244481
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-244481
Publikováno v:
Molecular and Cellular Endocrinology. 220:21-29
Cytokines may be involved in islet destruction during Type 1 diabetes. Exposure to interleukin-1beta (IL-1beta) or IL-1beta plus interferon-gamma (IFN-gamma) of rodent islets induces expression of inducible nitric oxide synthase (iNOS) and cyclooxyge
Publikováno v:
Cytokine. 43(1)
Elevated levels of glucose and free fatty acids as well as changes in the cytokine production are common features of both type 1 and type 2 diabetes. Especially regarding type 1 diabetes, immunological factors are believed to be responsible for much
Publikováno v:
Scandinavian journal of immunology. 63(5)
Occupancy of Fc gamma receptors (FcgammaR) by immune complexes (IC) induces secretion of various inflammatory mediators and cytokines. Therefore, knowledge of the FcR function is fundamental for understanding inflammatory processes. Here, we report a
Publikováno v:
Journal of immunological methods. 307(1-2)
Cytokines produced by Th1 or Th2 cells have been postulated to be important in the development of type 1 diabetes in humans and animal models, such as murine multiple low-dose streptozotocin (MLDSTZ)-induced diabetes. The aim of this study was to inv
Publikováno v:
The Journal of Immunology. 190:43.11-43.11
Despite intense research on the role of the regulatory T cells (Treg) , the kinetics of regulatory T cells in the early development of T1D is still not clear. We have examined the proportions of CD4+CD25+Foxp3+ regulatory T (Treg) cells and CD4+ T he