Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lina Schukur"'
Autor:
Hélène Chassin, Barbara Geering, Lina Schukur, David Ausländer, Brian Lang, Martin Fussenegger
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The standard treatment for an allergic response is anti-histamines, steroids and anti-IgE antibodies. Here the authors present a genetic circuit that senses IL-4 and IL-13 and responses with DARPin production to bind IgE.
Externí odkaz:
https://doaj.org/article/33084c3c97df4da3aeedbbb2271d4033
Autor:
Swann Gaulis, Lina Schukur, Leon Hellmann, Vanessa Cornacchione, Ulrike Naumann, Christoph Gaul, Ralph Tiedt, Francesco Hofmann, Louise Barys, Eric Billy, Elisabetta Traggiai, Sebastian Bergling, Moriko Ito, Ying Lin, Antoine de Weck, Grainne Kerr, Barbara Schacher Engstler, David A. Ruddy, Selina Jansky, Caroline Dafflon, Andreas Weiss, Frédéric Stauffer, Karen Kapur
Publikováno v:
Oncotarget
The histone 3 lysine 79 (H3K79) methyltransferase (HMT) DOT1L is known to play a critical role for growth and survival of MLL-rearranged leukemia. Serendipitous observations during high-throughput drug screens indicated that the use of DOT1L inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d34b52a22b6f0483ff80e96d4167efc
http://europepmc.org/articles/PMC7082114
http://europepmc.org/articles/PMC7082114
Autor:
Britta Knapp, Xiaoyou Liang, Beatrice Bauer-Probst, John S. Reece-Hoyes, Ines Barbosa, Angelica Mendiola, Tamara Zimmermann, Markus Reschke, Lina Schukur, Grainne Kerr, Claudio R. Thoma, Thomas Radimerski, Ole Niewoehner, Scott Gleim, Giorgio G. Galli, Melivoia Rapti
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
MYC oncoprotein is a multifunctional transcription factor that regulates the expression of a large number of genes involved in cellular growth, proliferation and metabolism. Altered MYC protein level lead to cellular transformation and tumorigenesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeaad6db63528f9236a2772f443c1a1a
https://pubmed.ncbi.nlm.nih.gov/33208877
https://pubmed.ncbi.nlm.nih.gov/33208877
Publikováno v:
Biotechnology and Bioengineering. 113:588-597
Encapsulated designer cells implanted into mice are currently used to validate the efficacy of therapeutic gene networks for the diagnosis and treatment of various human diseases in preclinical research. Because many human conditions cannot be adequa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90ab59e3e34bc027184b34bef500a03a
https://doi.org/10.1002/bit.25828
https://doi.org/10.1002/bit.25828
Autor:
Ulrich Schwaneberg, Marco Bocola, Jochen Wachtmeister, Lina Schukur, Marion B. Ansorge-Schumacher, Andre Jakoblinnert, Amol V. Shivange
Publikováno v:
Protein Engineering, Design and Selection. 26:291-298
The carbonyl reductase from Candida parapsilosis (CPCR2) is a versatile biocatalyst for the production of optically pure alcohols from ketones. Prochiral ketones like 2-methyl cyclohexanone are, however, only poorly accepted, despite CPCR2's large su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716263c1dd22a0e468d314c4ba8cf194
https://doi.org/10.1093/protein/gzt001
https://doi.org/10.1093/protein/gzt001
Autor:
Lina Schukur, Martin Fussenegger
Publikováno v:
Wiley interdisciplinary reviews. Systems biology and medicine. 8(5)
Synthetic biology is a promising multidisciplinary field that brings together experts in scientific disciplines from cell biology to engineering with the goal of constructing elements that do not occur in nature for use in various applications, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ae5ec401218fd6f6cc1792ba1ead63
https://pubmed.ncbi.nlm.nih.gov/27341681
https://pubmed.ncbi.nlm.nih.gov/27341681
Publikováno v:
Science translational medicine. 7(318)
Psoriasis is a chronic inflammatory skin disease characterized by a relapsing-remitting disease course and correlated with increased expression of proinflammatory cytokines, such as tumor necrosis factor (TNF) and interleukin 22 (IL22). Psoriasis is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa4ddd91356e75cb964f47c4d4d06c9
https://pubmed.ncbi.nlm.nih.gov/26680184
https://pubmed.ncbi.nlm.nih.gov/26680184