Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lina Sakhneny"'
Autor:
Guzel Burganova, Anat Schonblum, Lina Sakhneny, Alona Epshtein, Tomer Wald, Mika Tzaig, Limor Landsman
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionImmune cells were recently shown to support β-cells and insulin secretion. However, little is known about how islet immune cells are regulated to maintain glucose homeostasis. Administration of various cytokines, including Interleukin-33
Externí odkaz:
https://doaj.org/article/5bb295c115024a1d86543465a537de3e
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract β-Cells depend on the islet basement membrane (BM). While some islet BM components are produced by endothelial cells (ECs), the source of others remains unknown. Pancreatic pericytes directly support β-cells through mostly unidentified sec
Externí odkaz:
https://doaj.org/article/04c49dec808b409ab8df48674718bbbd
Publikováno v:
Molecular Metabolism, Vol 6, Iss 10, Pp 1330-1338 (2017)
Objective: The maintenance and expansion of β-cell mass rely on their proliferation, which reaches its peak in the neonatal stage. β-cell proliferation was found to rely on cells of the islet microenvironment. We hypothesized that pericytes, which
Externí odkaz:
https://doaj.org/article/3413ca3a5f9347d2bafa4222dd64acae
Autor:
Laura Glorieux, Aleksandra Sapala, David Willnow, Manon Moulis, Anna Salowka, Jean-Francois Darrigrand, Shlomit Edri, Anat Schonblum, Lina Sakhneny, Laura Schaumann, Harold F. Gómez, Christine Lang, Lisa Conrad, Fabien Guillemot, Shulamit Levenberg, Limor Landsman, Dagmar Iber, Christophe E. Pierreux, Francesca M. Spagnoli
Publikováno v:
Development, 149 (3)
Development (Cambridge, England), Vol. 149, no.3, p. dev199655 [1-14] (2022)
Development (Cambridge, England), Vol. 149, no.3, p. dev199655 [1-14] (2022)
Generating comprehensive image maps, while preserving spatial three-dimensional (3D) context, is essential in order to locate and assess quantitatively specific cellular features and cell-cell interactions during organ development. Despite recent adv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549a2a83bba3bec8803fc07efef75b20
https://hdl.handle.net/20.500.11850/530558
https://hdl.handle.net/20.500.11850/530558
Publikováno v:
Seminars in Cell & Developmental Biology. 92:89-96
Pancreas organogenesis depends on proper interactions of endoderm-derived epithelial cells, which will form the exocrine and endocrine cells of the adult organ, with their surrounding mesenchymal layer. Research on the role of pancreatic mesenchyme,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15903b7b9a8fa8ec20d3548285e2a1f2
https://doi.org/10.1016/j.semcdb.2018.08.012
https://doi.org/10.1016/j.semcdb.2018.08.012
Autor:
Lina Sakhneny, Neta Harari, Klemens J. Hertel, Laura Khalifa-Malka, Matthias Hebrok, Anke Busch, Limor Landsman
Publikováno v:
Developmental Biology
The embryonic origin of pericytes is heterogeneous, both between and within organs. While pericytes of coelomic organs were proposed to differentiate from the mesothelium, a single-layer squamous epithelium, the embryonic origin of pancreatic pericyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4df29adf691032b223f81e052e7044
https://doi.org/10.1016/j.ydbio.2019.01.020
https://doi.org/10.1016/j.ydbio.2019.01.020
Autor:
Shani Blanga-Kanfi, Assaf Ganoth, Ekaterina Lazdon, Limor Landsman, Dan Frenkel, Yossi Tsfadia, Guy Goldsmith, Lina Sakhneny, Hilit Levy-Barazany, Yuval Nash, Nofit Borenstein-Auerbach, Adi Kopelevich, Tali Benromano, Raphael Alhadeff, Katia Pozyuchenko
Publikováno v:
The FASEB Journal. 35
Inhibition of insulin-degrading enzyme (IDE) is a possible target for treating diabetes. However, it has not yet evolved into a medical intervention, mainly because most developed inhibitors target the zinc in IDE's catalytic site, potentially causin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b344a579d7e7513f01f0bb1b5ee06b
https://doi.org/10.1096/fj.201901945r
https://doi.org/10.1096/fj.201901945r
Autor:
Lina Sakhneny, Francesca M. Spagnoli, Laura Mueller, Anat Schonblum, Guzel Burganova, Abigail Isaacson, Heather Wilson, Sivan Azaria, Limor Landsman, Alona Epshtein
Publikováno v:
Developmental cell. 56(19)
Glucose homeostasis depends on regulated insulin secretion from pancreatic β cells, which acquire their mature phenotype postnatally. The functional maturation of β cells is regulated by a combination of cell-autonomous and exogenous factors; the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c867396bf2e6497491f92cd5589b5305
https://pubmed.ncbi.nlm.nih.gov/34499867
https://pubmed.ncbi.nlm.nih.gov/34499867
Autor:
Aleksandra Sapala, Schonblum A, Lina Sakhneny, David Willnow, Edri S, Lang C, Darrigrand J, Conrad L, Glorieux L, Francesca M. Spagnoli, Limor Landsman, Shulamit Levenberg, Schaumann L, Pierreux C, Harold F. Gómez, Guillemot F, Moulis M, Dagmar Iber
Publikováno v:
bioRxiv
bioRxiv, p. [1-43] (2021)
bioRxiv, p. [1-43] (2021)
Generating comprehensive image maps, while preserving spatial 3D context, is essential to quantitatively assess and locate specific cellular features and cell-cell interactions during organ development. Despite the recent advances in 3D imaging appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5375f58e9ee305b7b8d9eb4c291c0c
Autor:
Alona Epshtein, Lina Sakhneny, Daria Baer, Adi Sasson, Limor Landsman, Eleonor Rachi, Michal Lisnyansky
Publikováno v:
Diabetes. 65:3008-3014
β-Cells rely on the islet microenvironment for their functionality and mass. Pericytes, along with endothelial cells, make up the dense islet capillary network. However, although the role of endothelial cells in supporting β-cell homeostasis has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d714118325c4bd4c8e3c70d3bb4f828
https://doi.org/10.2337/db16-0365
https://doi.org/10.2337/db16-0365