Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Lina Misevičienė"'
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Akademický článek
Mechanism of Two-/Four-Electron Reduction of Nitroaromatics by Oxygen-Insensitive Nitroreductases: The Role of a Non-Enzymatic Reduction Step
Autor: Benjaminas Valiauga, Lina Misevičienė, Michelle H. Rich, David F. Ackerley, Jonas Šarlauskas, Narimantas Čėnas
Publikováno v: Molecules, Vol 23, Iss 7, p 1672 (2018)
Oxygen-insensitive NAD(P)H:nitroreductases (NR) reduce nitroaromatics (Ar-NO2) into hydroxylamines (Ar-NHOH) through nitroso (Ar-NO) intermediates. Ar-NO may be reduced both enzymatically and directly by reduced nicotinamide adenine dinucleotide or i
Externí odkaz: https://doaj.org/article/75ad8b375a5f4cbb9451cf4301a5af85
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2
The comparative study of redox properties of recombinant human cytosolic and mitochondrial NADPH: thioredoxin reductases
Autor: Lina Misevičienė, Kastis Krikštopaitis, Narimantas Čėnas
Publikováno v: Chemija. 33
We compared the redox properties of recombinant cytosolic (TrxR1) and mitochondrial (TrxR2) isoforms of human flavosulfoselenoenzyme NADPH:thioredoxin reductase. The standard redox potentials of isoenzymes (E0 7), determined according to the redox eq
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2cbd682dd67a4a95dea07805fa554807
https://doi.org/10.6001/chemija.v33i2.4707
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4
5Flavoenzyme-catalyzed single-electron reduction of nitroaromatic antiandrogens: implications for their cytotoxicity
Autor: Aušra, Nemeikaitė-Čėnienė, Audronė, Marozienė, Lina, Misevičienė, Jelena, Tamulienė, Aliaksei V, Yantsevich, Narimantas, Čėnas
Publikováno v: Free radical research. 55(3)
The therapeutic action of nitroaromatic antiandrogens nilutamide and flutamide may be complicated by their cytotoxicity, whose mechanisms are still incomprehensively understood. In particular this concerns the enzymatic redox cycling of flutamide and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a0ab4f9c91c75d89c7108dfed15a4862
https://pubmed.ncbi.nlm.nih.gov/34098820
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5
Flavoenzyme-catalyzed single-electron reduction of nitroaromatic antiandrogens: implications for their cytotoxicity
Autor: Aušra Nemeikaitė-Čėnienė, A. V. Yantsevich, Jelena Tamulienė, Audronė Marozienė, Narimantas Čėnas, Lina Misevičienė
The therapeutic action of nitroaromatic antiandrogens nilutamide and flutamide may be complicated by their cytotoxicity, whose mechanisms are still incomprehensively understood. In particular this concerns the enzymatic redox cycling of flutamide and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25bd54c0f904b51d745a66926bb0da2
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7
Aerobic cytotoxicity of aromatic N-oxides: the role of NAD(P)H:quinone oxidoreductase (NQO1)
Autor: Audronė Marozienė, Mindaugas Lesanavičius, Aušra Nemeikaitė-Čėnienė, Jonas Šarlauskas, Violeta Jonušienė, Narimantas Čėnas, Lina Misevičienė
Publikováno v: International journal of molecular sciences, Basel : MDPI, 2020, vol. 21, iss. 22, art. no. 8754, p. [1-13]
International Journal of Molecular Sciences
Volume 21
Issue 22
International Journal of Molecular Sciences, Vol 21, Iss 8754, p 8754 (2020)
Derivatives of tirapazamine and other heteroaromatic N-oxides (ArN&rarr
O) exhibit tumoricidal, antibacterial, and antiprotozoal activities, which are typically attributed to bioreductive activation and free radical generation. In this work, we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81792b1b6d53491a269befb96c01c73b
https://repository.vu.lt/VU:ELABAPDB80478955&prefLang=en_US
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8
Kinetics of flavoenzyme-catalyzed reduction of tirapazamine derivatives: implications for their prooxidant cytotoxicity
Autor: Narimantas Čėnas, Violeta Jonušienė, Lina Misevičienė, A. V. Yantsevich, Aušra Nemeikaitė-Čėnienė, Audronė Marozienė, Jonas Šarlauskas
Publikováno v: International journal of molecular sciences: Special issue: Bioreductive activation/detoxification of prooxidant xenobiotics and drugs, Basel : MDPI, 2019, vol. 20, no. 18, p. 4602-4616
International Journal of Molecular Sciences
Volume 20
Issue 18
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4602 (2019)
Derivatives of tirapazamine and other heteroaromatic N-oxides (ArN&rarr
O) exhibit promising antibacterial, antiprotozoal, and tumoricidal activities. Their action is typically attributed to bioreductive activation and free radical generation. I
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea22ff7141a2128b1d6ed5cb463bad9
https://repository.vu.lt/VU:ELABAPDB49008306&prefLang=en_US
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9
Enzymatic single-electron reduction and aerobic cytotoxicity of tirapazamine and its 1-oxide and nor-oxide metabolites
Autor: Aušra Nemeikaitė-Čėnienė, Jonas Šarlauskas, Audronė Marozienė, Narimantas Čėnas, Lina Misevičienė, Mindaugas Lesanavičius
Publikováno v: Chemija. 29
Aerobic cytotoxicity of 3-amino-1,2,4-benzotriazine-1,4-dioxide (tirapazamine, TPZ), a bioreductively activated hypoxia-specific anticancer agent, is responsible for TPZ side effects in chemotherapy. In order to clarify its mechanisms, we examined th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::214cf1b3131929feeb0da74d59ce87b8
https://doi.org/10.6001/chemija.v29i4.3843
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10
Quinones and nitroaromatic compounds as subversive substrates of Staphylococcus aureus flavohemoglobin
Autor: Florence Lederer, Laura Baciou, Narimantas Čėnas, Audronė Marozienė, Myriam Moussaoui, Žilvinas Anusevičius, Lina Misevičienė
Publikováno v: Free Radical Biology and Medicine
Free Radical Biology and Medicine, Elsevier, 2018, 123, pp.107-115. ⟨10.1016/j.freeradbiomed.2018.05.071⟩
In microorganisms, flavohemoglobins (FHbs) containing FAD and heme (Fe3+, metHb) convert NO. into nitrate at the expense of NADH and O2. FHbs contribute to bacterial resistance to nitrosative stress. Therefore, inhibition of FHbs functions may decrea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890d0271819669beb408efa9c3222d2d
https://hal.archives-ouvertes.fr/hal-02368450
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