Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lina Meinecke"'
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 11, p e1006569 (2018)
How does pattern formation occur accurately when confronted with tissue growth and stochastic fluctuations (noise) in gene expression? Dorso-ventral (D-V) patterning of the mandibular arch specifies upper versus lower jaw skeletal elements through a
Externí odkaz:
https://doaj.org/article/8c593382691a48bc859cf4965438e83e
Autor:
Martin H. Voss, Arun A. Azad, Aaron R. Hansen, Jhanelle E. Gray, Sarah J. Welsh, Xuyang Song, Michael Kuziora, Lina Meinecke, Jorge Blando, Ikbel Achour, Yi Wang, Farzana L. Walcott, Sjoukje F. Oosting
Publikováno v:
Clinical Cancer Research. 28:3032-3041
Purpose: MEDI0680 is a humanized anti–programmed cell death-1 (PD-1) antibody, and durvalumab is an anti-PD-L1 antibody. Combining treatment using these antibodies may improve efficacy versus blockade of PD-1 alone. This phase II study evaluated an
Autor:
Sjoukje F. Oosting, Farzana L. Walcott, Yi Wang, Ikbel Achour, Jorge Blando, Lina Meinecke, Michael Kuziora, Xuyang Song, Sarah J. Welsh, Jhanelle E. Gray, Aaron R. Hansen, Arun A. Azad, Martin H. Voss
Supplementary Figure from A Randomized Phase II Study of MEDI0680 in Combination with Durvalumab versus Nivolumab Monotherapy in Patients with Advanced or Metastatic Clear-cell Renal Cell Carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15fba7a4c3002c9cc8f82b28dcf07d21
https://doi.org/10.1158/1078-0432.22487043
https://doi.org/10.1158/1078-0432.22487043
Autor:
Sjoukje F. Oosting, Farzana L. Walcott, Yi Wang, Ikbel Achour, Jorge Blando, Lina Meinecke, Michael Kuziora, Xuyang Song, Sarah J. Welsh, Jhanelle E. Gray, Aaron R. Hansen, Arun A. Azad, Martin H. Voss
Purpose:MEDI0680 is a humanized anti–programmed cell death-1 (PD-1) antibody, and durvalumab is an anti-PD-L1 antibody. Combining treatment using these antibodies may improve efficacy versus blockade of PD-1 alone. This phase II study evaluated ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a90975dd8fcf92fc4c41ce20296e40
https://doi.org/10.1158/1078-0432.c.6532443.v1
https://doi.org/10.1158/1078-0432.c.6532443.v1
Autor:
Sjoukje F. Oosting, Farzana L. Walcott, Yi Wang, Ikbel Achour, Jorge Blando, Lina Meinecke, Michael Kuziora, Xuyang Song, Sarah J. Welsh, Jhanelle E. Gray, Aaron R. Hansen, Arun A. Azad, Martin H. Voss
Supplementary Table from A Randomized Phase II Study of MEDI0680 in Combination with Durvalumab versus Nivolumab Monotherapy in Patients with Advanced or Metastatic Clear-cell Renal Cell Carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f7f333933fe113b04c91d3acc099d4
https://doi.org/10.1158/1078-0432.22487034.v1
https://doi.org/10.1158/1078-0432.22487034.v1
Autor:
Marco Gymnopoulos, Tima Thomas, Diana Gasper, Judith Anderton, Ravinder Tammali, Ed Rosfjord, Nick Durham, Chris Ward, Claire Myers, Jixin Wang, Wenyan Zhong, Simon Christ, Lina Meinecke, Katharina Nekolla, Laura Sebastian Monasor, Roger Dodd, Neki Patel, Mark Albertella, Jorge Zeron-Medina, Paula Fraenkel, Puja Sapra
Publikováno v:
Cancer Research. 83:LB025-LB025
Folate receptor alpha (FRα) is a cell surface GPI-anchored protein overexpressed in several solid tumors with highest prevalence in ovarian cancer and lung adenocarcinoma but restricted expression in normal tissues. An antibody drug conjugate (ADC)
Autor:
Farzad Sekhavati, Lina Meinecke, Ansh Kapil, Anatoliy Shumilov, Jan Martin Lesniak, Guenter Schmidt, Thomas Padel
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A392-A393
BackgroundThe pathologist’s visual assessment of tumor proportion score (TPS) with 25% cutoff on PD-L1 stained tissue samples is an established method to select metastatic NSCLC patients that are likely to respond to an anti-PD-L1 monotherapy.1 How
Autor:
Hadassah Sade, Ansh Kapil, Philipp Wortmann, Andreas Spitzmueller, Nicolas Triltsch, Lina Meinecke, Susanne Haneder, Anatoliy Shumilov, Jan Lesniak, Valeria Bertani, Tze-Heng Tan, Ana Hidalgo-Sastre, Simon Christ, Andrea Storti, Regina Alleze, Dasa Medrikova, Jessica Chan, Simon Lanzmich, Markus Schick, Guenter Schmidt, J. Carl Barrett
Publikováno v:
Cancer Research. 82:468-468
Many targeted cancer therapies rely on biomarkers, which are assessed by standard pathologist scoring of immunohistochemically stained tissue. However, this process is subjective, semi-quantitative and does not assess expression heterogeneity. A quan
Autor:
Lina Meinecke, Jorge Blando, Thomas Herz, Michael Surace, Thomas Padel, Monica Azqueta Gavaldon, Harald Hessel, Farzad Sekhavati, Megha Saraiya, Anmarie Boutrin, Karma Da Costa, Jaime Rodriguez Canales, Ashok Gupta, Carl Barrett, Zachary Aaron Cooper, Ikbel Achour
Publikováno v:
Cancer Research. 82:1235-1235
Introduction: Predictive biomarkers of anti‒PD-(L)1 therapies have largely focused on the tumor - T cell axis where tumor cell PD-L1 expression has demonstrated its clinical utility in predicting overall survival (OS) in patients with advanced non-
Autor:
Lina Meinecke, Adam L. MacLean, David E. Clouthier, Qing Nie, Praveer P. Sharma, Thomas F. Schilling
Publikováno v:
Genesis (New York, N.Y. : 2000), vol 57, iss 1
The mandibular or first pharyngeal arch forms the upper and lower jaws in all gnathostomes. A gene regulatory network that defines ventral, intermediate, and dorsal domains along the dorsal-ventral (D-V) axis of the arch has emerged from studies in z