Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lina Happo"'
Autor:
Liz J. Valente, Brandon J. Aubrey, Marco J. Herold, Gemma L. Kelly, Lina Happo, Clare L. Scott, Andrea Newbold, Ricky W. Johnstone, David C.S. Huang, Lyubomir T. Vassilev, Andreas Strasser
Publikováno v:
Cell Reports, Vol 14, Iss 8, Pp 1858-1866 (2016)
Nutlin3a is a small-molecule antagonist of MDM2 that promotes non-genotoxic activation of p53 through p53 protein stabilization and transactivation of p53 target genes. Nutlin3a is the forerunner of a class of cancer therapeutics that have reached cl
Externí odkaz:
https://doaj.org/article/52a55445e4b54bfcb568bd86fe2147c2
Autor:
Clare L. Scott, Liz J. Valente, Andreas Strasser, Ricky W. Johnstone, Brandon J. Aubrey, David C.S. Huang, Gemma L. Kelly, Lyubomir T. Vassilev, Andrea Newbold, Lina Happo, Marco J Herold
Publikováno v:
Cell Reports, Vol 14, Iss 8, Pp 1858-1866 (2016)
SummaryNutlin3a is a small-molecule antagonist of MDM2 that promotes non-genotoxic activation of p53 through p53 protein stabilization and transactivation of p53 target genes. Nutlin3a is the forerunner of a class of cancer therapeutics that have rea
Autor:
Lina Happo, Andreas Strasser, Matthew J. Carter, Stuart Blakemore, Graham Packham, Mark S. Cragg, Yury D. Bogdanov, Clare L. Scott, Kerry L. Cox
Publikováno v:
Cell Death & Differentiation. 23:303-312
Genetic recombination during B-cell development regularly results in the generation of autoreactive, potentially pathogenic B-cell receptors (BCRs). Consequently, multiple mechanisms link inappropriate BCR specificity to clonal deletion. Similar path
Autor:
Asvini K, Subasinghe, Lina, Happo, Yasmin L, Jayasinghe, Suzanne M, Garland, Alexandra, Gorelik, John D, Wark
Publikováno v:
Australian family physician. 45(11)
Little is known about the severity of dysmenorrhoea and attitudes towards its management in young females.The aim of this study was to evaluate the prevalence and severity of dysmenorrhoea in women aged 16-25 years.Participants were recruited via tar
Autor:
Ewa M. Michalak, Lindsay C. Spender, Louise J. Clark, Gareth J. Inman, Mark S. Cragg, Jian Yu, Matthew J. Carter, Lina Happo, Darren I. O'Brien
Publikováno v:
The Journal of Biological Chemistry
Background: TGF-β induces apoptosis in Burkitt's lymphoma cells. Results: PUMA is a direct target gene of TGF-β signaling and is required for rapid apoptosis. Conclusion: TGF-β-mediated direct induction of PUMA contributes to apoptosis in human an
Publikováno v:
Journal of Cell Science. 125:1081-1087
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). Caspases cleave vital proteins, leading the cell to fragment into vesicles that are rap
Autor:
Andreas Strasser, Kylie D. Mason, Lina Happo, Michele Cook, P N Kelly, Stephanie Grabow, Paul Waring
Publikováno v:
Cell Death & Differentiation. 19:623-632
The tumour suppressor p53 transcriptionally regulates a range of target genes that control cell growth and survival. Mutations of p53 have been implicated in the development of approximately 50% of human cancers, including those instigated by exposur
Autor:
Mark S. Cragg, Gordon K. Smyth, Marco J Herold, Andreas Strasser, Clare L. Scott, Lina Happo, Cassandra J. Vandenberg, Elisa S. Jansen, Jon M. Haga, Grant Dewson, Belinda Phipson, Suzanne Cory, Ewa M. Michalak
Publikováno v:
Blood. 116:5256-5267
DNA-damaging chemotherapy is the backbone of cancer treatment, although it is not clear how such treatments kill tumor cells. In nontransformed lymphoid cells, the combined loss of 2 proapoptotic p53 target genes, Puma and Noxa, induces as much resis
Autor:
Georges Garnier, Ludivine A. Pradelli, Laura Mondragón, Johanna Chiche, Jean-François Michiels, Julie Reverso-Meinietti, Ewa M. Michalak, Nicolas Mounier, Michel Carles, Ophélie Meynet, Barbara Zunino, Lina Happo, Jean-Ehrland Ricci, Bruno Taillan, Jean-François Tanti, Clare L. Scott, Marie A. Jacquin
Publikováno v:
Blood. 122(14)
Caloric restriction (CR) is proposed to decrease tumorigenesis through a variety of mechanisms including effects on glycolysis. However, the understanding of how CR affects the response to cancer therapy is still rudimentary. Here, using the Eµ-Myc
Autor:
Andreas Strasser, Lina Happo, Warren S. Alexander, Andrew M. Lew, Jian-Guo Zhang, Philip D. Hodgkin, Susanne Heinzel, Clare L. Scott, Paul G. F. Koenen, Emma M. Carrington, Marco J Herold
Publikováno v:
Nature Communications
Two major processes govern T cell proliferation and survival: interleukin-7-mediated homeostasis and antigen-induced selection. How cells transit between the two states is unknown. Here we show that T cell receptor ligation actively inhibits homeosta