Výsledky vyhledávání - "Lina Emilsson"

QKI6B mRNA levels are upregulated in schizophrenia and predict GFAP expression

Autor: Bryn Farnsworth, Katarzyna J. Radomska, Bettina M. Zimmermann, Elena Jazin, Petronella Kettunen, Lina Emilsson

Publikováno v: Brain research. 1669

Schizophrenia is a highly heritable disorder with a heterogeneous symptomatology. Research increasingly indicates the importance of the crucial and often overlooked glial perturbations within schizophrenia. Within this study, we examined an isoform o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bfcc536eeb47bebb13a424b2b8e6a5
https://pubmed.ncbi.nlm.nih.gov/28552414

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Reduced gene expression levels ofMunc13-1and additional components of the presynaptic exocytosis machinery upon conditional targeting ofVglut2in the adolescent mouse

Autor: Aparna Rajagopalan, Nadine Schweizer, Karin Nordenankar, Lina Emilsson, Sultana Nilufar Jahan, Åsa Wallén-Mackenzie

Publikováno v: Synapse. 68:624-633

Presynaptic proteins orchestrate an intricate interplay of dynamic interactions in order to regulate quantal exocytosis of transmitter-filled vesicles, and their dysregulation might cause neurological and neuropsychiatric dysfunction. Mice carrying a

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https://doi.org/10.1002/syn.21776

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Characterization and Expression of the Zebrafish qki Paralogs

Autor: Åsa Tellgren-Roth, Petronella Kettunen, Giulia Tuveri, Lina Emilsson, Katarzyna J. Radomska, Elena Jazin, Jonathan Sager, Bryn Farnsworth, Christiane Peuckert

Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0146155 (2016)
PLoS ONE

Quaking (QKI) is an RNA-binding protein involved in post-transcriptional mRNA processing. This gene is found to be associated with several human neurological disorders. Early expression of QKI proteins in the developing mouse neuroepithelium, togethe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57bc5a74d1dbb057bee6c4f4a3e2a517
http://europepmc.org/articles/PMC4699748?pdf=render

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Gene Expression of Quaking in Sporadic Alzheimer’s Disease Patients is Both Upregulated and Related to Expression Levels of Genes Involved in Amyloid Plaque and Neurofibrillary Tangle Formation

Autor: Lina Emilsson, Bettina M. Zimmermann, Elena Jazin, Petronella Kettunen, Christiane Peuckert, Bryn Farnsworth

Publikováno v: Journal of Alzheimer's Disease

Quaking (QKI) is a gene exclusively expressed within glial cells. QKI has previously been implicated in various neurological disorders and diseases, including Alzheimer's disease (AD), a condition for which increasing evidence suggests a central role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ac72e58f47298e2b6bb0e7a527d2e8
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-286589

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Autor: Peter Saetre, Lina Emilsson, Elena Jazin

Publikováno v: Synapse. 65:971-974

In the normal brain, age is associated with changes in gene expression. Age is also a prominent risk factor for Alzheimer's disease (AD), where clinical features are similar to age-related decreases in cognitive performance. We hypothesized that some

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::656ebdf869f2d3794e65c005507c0fbe
https://doi.org/10.1002/syn.20933

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Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline development

Autor: Kuljeet Singh Sandhu, Anita Göndör, Liang Liu, Lina Emilsson, Mikael Sjölinder, Vijay K. Tiwari, Rolf Ohlsson, Sylvain Guibert, Marta P. Imreh, Zhihu Zhao, Chengxi Shi

Publikováno v: Genes & Development. 23:2598-2603

Recent observations highlight that the mammalian genome extensively communicates with itself via long-range chromatin interactions. The causal link between such chromatin cross-talk and epigenetic states is, however, poorly understood. We identify he

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https://doi.org/10.1101/gad.552109

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Immunoaffinity Enrichments Followed by Mass Spectrometric Detection for Studying Global Protein Tyrosine Phosphorylation

Autor: Christopher M. Adams, Lioudmila Elfineh, Åke Engström, Roman A. Zubarev, Ludwig Hedberg, Michael L. Nielsen, Eva Andersson, Magnus Molin, Lina Emilsson, Jonas Åström, Sara Bergström Lind, Mikhail M. Savitski, Ulf Pettersson

Publikováno v: Journal of Proteome Research. 7:2897-2910

Phosphorylation of protein tyrosine residues regulates important cell functions and is, when dysregulated, often crucially involved in oncogenesis. It is therefore important to develop and evaluate methods for identifying and studying tyrosine phosph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb993301389f76c121d1aa29b0a827f
https://doi.org/10.1021/pr8000546

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SLC10A4 is a vesicular amine-associated transporter modulating dopamine homeostasis

Autor: Christiane Peuckert, Carolina Birgner, Emma Arvidsson, Lina Emilsson, Jerker Widengren, Åsa Wallén-Mackenzie, Martin Larhammar, Reinhard Jahn, Martina Blunder, Christoph Limbach, Kalicharan Patra, Hans Blom, Julia Preobraschenski, Daniel Rönnlund, Klas Kullander

Publikováno v: Biological Psychatry
Europe PubMed Central

BACKGROUND: The neuromodulatory transmitters, biogenic amines, have profound effects on multiple neurons and are essential for normal behavior and mental health. Here we report that the orphan transporter SLC10A4, which in the brain is exclusively ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f2547cf77616797ac1497a6df6712b
https://hdl.handle.net/11858/00-001M-0000-0025-7742-E11858/00-001M-0000-0025-7741-011858/00-001M-0000-0025-773F-7

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Low mRNA levels of RGS4 splice variants in Alzheimer's disease: Association between a rare haplotype and decreased mRNA expression

Autor: Lina Emilsson, Elena Jazin, Peter Saetre

Publikováno v: Synapse. 59:173-176

Regulator of G-protein signaling 4 (RGS4) showed decreased mRNA levels in Alzheimer's disease in a large collection of human brain autopsies from prefrontal cortex. The expression levels of three RGS4 splice variants were examined in the same samples

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af3501363c4402e8a1af241f7df5ede
https://doi.org/10.1002/syn.20226

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Alzheimer's disease: mRNA expression profiles of multiple patients show alterations of genes involved with calcium signaling

Autor: Lina Emilsson, Peter Saetre, Elena Jazin

Publikováno v: Neurobiology of Disease, Vol 21, Iss 3, Pp 618-625 (2006)

We combined global and high-resolution strategies to find genes with altered mRNA expression levels in one of the largest collection of brain autopsies from Alzheimer's patients and controls ever studied. Our global analysis involved microarray hybri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a874dcf0dae5dda79452f752d2fe0ea
http://www.sciencedirect.com/science/article/pii/S0969996105002494

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