Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Lina E Tze"'
Autor:
Lina E Tze, Brian R Schram, Kong-Peng Lam, Kristin A Hogquist, Keli L Hippen, Jiabin Liu, Susan A Shinton, Kevin L Otipoby, Peter R Rodine, Amanda L Vegoe, Manfred Kraus, Richard R Hardy, Mark S Schlissel, Klaus Rajewsky, Timothy W Behrens
Publikováno v:
PLoS Biology, Vol 3, Iss 3, p e82 (2005)
In developing B lymphocytes, a successful V(D)J heavy chain (HC) immunoglobulin (Ig) rearrangement establishes HC allelic exclusion and signals pro-B cells to advance in development to the pre-B stage. A subsequent functional light chain (LC) rearran
Externí odkaz:
https://doaj.org/article/fb872538aa824b9d9c88f9a8f5d24eae
Autor:
Debbie R. Howard, Satoshi Ishido, Carla M. Roots, Christopher C. Goodnow, Keisuke Horikawa, Christopher E. Andoniou, Heather Domaschenz, Robert J. Rigby, Mari Ohmura-Hoshino, Mariapia A. Degli-Esposti, David A. Way, Lina E. Tze
Publikováno v:
The Journal of Experimental Medicine
By opposing IL-10–driven, MARCH1-mediated ubiquitination and degradation of MHC class II, CD83 may boost the immunogenicity of dendritic cells.
Effective vaccine adjuvants must induce expression of major histocompatability (MHC) class II prote
Effective vaccine adjuvants must induce expression of major histocompatability (MHC) class II prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df20d2ccc525bc64b9f65da4ab2cb291
https://doi.org/10.1084/jem.20092203
https://doi.org/10.1084/jem.20092203
Autor:
Richard R. Hardy, Lydia Najera, Jiabin Liu, Amanda L. Vegoe, Keli L. Hippen, Michael A. Farrar, Brian R. Schram, Timothy W. Behrens, Lina E. Tze, Laura B. Ramsey
Publikováno v:
Experts@Minnesota
BCR editing in the bone marrow contributes to B cell tolerance by orchestrating secondary Ig rearrangements in self-reactive B cells. We have recently shown that loss of the BCR or a pharmacologic blockade of BCR proximal signaling pathways results i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e027d8f6ed7239e3903171fe7a94b2
https://doi.org/10.4049/jimmunol.180.7.4728
https://doi.org/10.4049/jimmunol.180.7.4728
Autor:
Keli L. Hippen, Valerie Kouskoff, Jason G. Cyster, H. Lucy Tang, Marc K. Jenkins, Kathryn A. Pape, David Nemazee, Lina E. Tze, Timothy W. Behrens
Publikováno v:
The Journal of Experimental Medicine
The life history of isotype-switched B cells is unclear, in part, because of an inability to detect rare antigen-specific B cells at early times during the immune response. To address this issue, a small population of B cells carrying targeted antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55889db1758b1a6f86f1dd39c0c7ba1d
https://doi.org/10.1084/jem.20012065
https://doi.org/10.1084/jem.20012065
Publikováno v:
The Journal of Experimental Medicine
Clonal anergy of autoreactive B cells is a key mechanism regulating tolerance. Here, we show that anergic B cells express significant surface levels of CD5, a molecule normally found on T cells and a subset of B-1 cells. Breeding of the hen egg lysoz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800fc65b9f5877e02be3218bb46a9a8f
https://doi.org/10.1084/jem.191.5.883
https://doi.org/10.1084/jem.191.5.883
Autor:
Anselm Enders, Heather Domaschenz, Jason G. Cyster, Katrina L. Randall, Fabienne Mackay, Belinda Whittle, Christopher C. Goodnow, Edyta M. Kucharska, Richard J. Cornall, Stuart G. Tangye, Tyani D. Chan, Robert Brink, Elissa K. Deenick, Tanya L. Crockford, Andy L Johnson, Carola G. Vinuesa, Bebhinn Treanor, Teresa Lambe, Duncan Alston, Tiphaine Bouriez-Jones, Facundo D. Batista, Michael J. Lenardo, Lina E. Tze, Tahra Camidge
To identify genes and mechanisms involved in humoral immunity, we did a mouse genetic screen for mutations that do not affect the first wave of antibody to immunization but disrupt response maturation and persistence. The first two mutants identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50868b2b4184178422fb6ecf36ccd805
https://europepmc.org/articles/PMC3437189/
https://europepmc.org/articles/PMC3437189/
Autor:
Marc K. Jenkins, Kathryn A. Pape, Brian R. Schram, Keli L. Hippen, Timothy W. Behrens, Lina E. Tze
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 175(2)
In normal B cell development, a large percentage of newly formed cells bear receptors with high levels of self-reactivity that must be tolerized before entry into the mature B cell pool. We followed the fate of self-reactive B cells expressing high a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc14b50ebc95acbb70d57f6338446e2
https://pubmed.ncbi.nlm.nih.gov/16002689
https://pubmed.ncbi.nlm.nih.gov/16002689
Autor:
Timothy W. Behrens, Richard R. Hardy, Susan A. Shinton, Kong-Peng Lam, Mark S. Schlissel, Amanda L. Vegoe, Jiabin Liu, Klaus Rajewsky, Keli L. Hippen, Kristin A. Hogquist, Peter R. Rodine, Brian R. Schram, Kevin L. Otipoby, Manfred Kraus, Lina E. Tze
Publikováno v:
PLoS Biology
PLoS Biology, Vol 3, Iss 3, p e82 (2005)
PLoS Biology, Vol 3, Iss 3, p e82 (2005)
In developing B lymphocytes, a successful V(D)J heavy chain (HC) immunoglobulin (Ig) rearrangement establishes HC allelic exclusion and signals pro-B cells to advance in development to the pre-B stage. A subsequent functional light chain (LC) rearran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7b2cc8cd834475d8eb973a1a9b0948
https://pubmed.ncbi.nlm.nih.gov/15752064
https://pubmed.ncbi.nlm.nih.gov/15752064
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 171(2)
Receptor editing is an important mechanism to modify the Ag specificity of newly developing B cells that are reactive with self-Ags. Previous studies have suggested that late immature B cells, bearing high levels of IgM on their cell surface, are una
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b0094e55a60e8be27e54a22d6dc3e0
https://pubmed.ncbi.nlm.nih.gov/12847233
https://pubmed.ncbi.nlm.nih.gov/12847233
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 165(12)
Receptor editing in the bone marrow (BM) serves to modify the Ag receptor specificity of immature self-reactive B cells, while anergy functionally silences self-reactive clones. Here, we demonstrate that anergic B cells in hen egg lysozyme Ig (HEL-Ig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70bc576dd8696cb30370be988adc9e39
https://pubmed.ncbi.nlm.nih.gov/11120801
https://pubmed.ncbi.nlm.nih.gov/11120801