Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lina Abou Saleh"'
Autor:
Daniel Irelan, Abigail Boyd, Edward Fiedler, Peter Lochmaier, Will McDonough, Ileana V. Aragon, Lyudmila Rachek, Lina Abou Saleh, Wito Richter
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3260 (2023)
cAMP-phosphodiesterase 4 (PDE4) inhibitors are currently approved for the treatment of inflammatory diseases. There is interest in expanding the therapeutic application of PDE4 inhibitors to metabolic disorders, as their chronic application induces w
Externí odkaz:
https://doaj.org/article/dc58a982ceaf496c8bc304a240c1f2eb
Autor:
Abigail Boyd, Peter Lochmaier, Daniel Irelan, Edward Fiedler, Ji Young Lee, Brian Fouty, Lina Abou Saleh, Wito Richter
Publikováno v:
Biology, Vol 11, Iss 11, p 1582 (2022)
The analysis of blood samples from mice treated with the PDE4 inhibitor Roflumilast revealed an unexpected reduction in serum potassium levels, while sodium and chloride levels were unaffected. Treatment with several structurally distinct PAN-PDE4 in
Externí odkaz:
https://doaj.org/article/537b5a864ca943e1b182e86e6190e065
Autor:
Abigail Boyd, Ileana V. Aragon, Justin Rich, Will McDonough, Marianna Oditt, Daniel Irelan, Edward Fiedler, Lina Abou Saleh, Wito Richter
Publikováno v:
Biology, Vol 10, Iss 12, p 1355 (2021)
Treatment with PAN-PDE4 inhibitors has been shown to produce hypothermia in multiple species. Given the growing body of evidence that links nausea and emesis to disturbances in thermoregulation in mammals, we explored PDE4 inhibitor-induced hypotherm
Externí odkaz:
https://doaj.org/article/68a9b275b8504172a7584ff248764bbd
Autor:
Brant M. Wagener, Naseem Anjum, Sarah C. Christiaans, Morgan E. Banks, Jordan C. Parker, Adam T. Threet, Rashidra R. Walker, Kayla D. Isbell, Stephen A. Moser, Troy Stevens, Mikhail F. Alexeyev, Jonathon P. Audia, Wito Richter, Kierra S. Hardy, Lina Abou Saleh, Charity Morgan, Jean-François Pittet
Publikováno v:
Toxins, Vol 12, Iss 6, p 369 (2020)
Pseudomonas aeruginosa is an opportunistic pathogen that causes pneumonia in immunocompromised and intensive care unit (ICU) patients. During host infection, P. aeruginosa upregulates the type III secretion system (T3SS), which is used to intoxicate
Externí odkaz:
https://doaj.org/article/79899cf953824f7faf6eb5035ca2568e
Publikováno v:
Biochem J
Saliva, while often taken for granted, is indispensable for oral health and overall well-being, as inferred from the significant impairments suffered by patients with salivary gland dysfunction. Here, we show that treatment with several structurally
Autor:
Abigail Boyd, Lina Abou Saleh, Ileana Aragon, Edward Fiedler, Daniel Irelan, Domenico Spadafora, Robert Barrington, Judy King, Wito Richter
Publikováno v:
The FASEB Journal. 36
Autor:
Abigail Boyd, Ileana V. Aragon, Wito Richter, Wadad Mneimneh, Robert A. Barrington, Anna Koloteva, Domenico Spadafora, Lina Abou Saleh
Publikováno v:
FASEB J
Pseudomonas aeruginosa is a frequent cause of hospital-acquired lung infections characterized by hyperinflammation, antibiotic resistance, and high morbidity/mortality. Here, we show that the genetic ablation of one cAMP-phosphodiesterase 4 subtype,
Autor:
Abigail Boyd, Ileana V. Aragon, Will McDonough, Wito Richter, Justin Rich, Anna Koloteva, Lina Abou Saleh
Publikováno v:
The FASEB Journal. 35
Publikováno v:
The FASEB Journal. 35
Autor:
Will McDonough, Justin Rich, Ileana V. Aragon, Wito Richter, Lina Abou Saleh, Abigail Boyd, Anna Koloteva
Publikováno v:
Biochem Pharmacol
Despite major advances, there remains a need for novel anesthetic drugs or drug combinations with improved efficacy and safety profiles. Here, we show that inhibition of cAMP-phosphodiesterase 4 (PDE4), while not inducing anesthesia by itself, potent