Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Lina A. Shehadeh"'
Publikováno v:
BMC Nephrology, Vol 24, Iss 1, Pp 1-6 (2023)
Abstract Background Alport syndrome (AS) is caused by mutations in type IV collagen genes that typically target and compromise the integrity of basement membranes in kidney, ocular, and sensorineural cochlear tissues. Type IV and V collagens are also
Externí odkaz:
https://doaj.org/article/17977fde255048d8882e403225b33b87
Autor:
Daniela Aguilar-Caballero, Jose M. C. Capcha, Veronica Caballero, Karen C. Young, Shahnaz Duara, Michael Borchetta, Ivan Gonzalez, Ali G. Saad, Keith A. Webster, Lina A. Shehadeh, Emmalee S. Bandstra, Augusto F. Schmidt
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
Vertical transmission of SARS-CoV-2 from mother to fetus is widely accepted. Whereas most infected neonates present with mild symptoms or are asymptomatic, respiratory distress syndrome (RDS) and abnormal lung images are significantly more frequent i
Externí odkaz:
https://doaj.org/article/1d6865de636c4485bd22d2241280863c
Publikováno v:
Biomedicines, Vol 11, Iss 12, p 3232 (2023)
Alzheimer’s disease (AD) is characterized by progressive accumulations of extracellular amyloid-beta (Aβ) aggregates from soluble oligomers to insoluble plaques and hyperphosphorylated intraneuronal tau, also from soluble oligomers to insoluble ne
Externí odkaz:
https://doaj.org/article/a70d05469e6449a19c289eb90465975b
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Echocardiography is frequently used to evaluate cardiac function in rodent models of cardiovascular disease. Whereas methods to acquire the commonly used echocardiography parameters are well-described in published protocols or manuals, many important
Externí odkaz:
https://doaj.org/article/7821c6d8a09d4acc8176cf3f4dccd52d
Autor:
Monique Williams, Jose Manuel Condor Capcha, Camila Iansen Irion, Grace Seo, Guerline Lambert, Ali Kamiar, Keyvan Yousefi, Rosemeire Kanashiro‐Takeuchi, Lauro Takeuchi, Ali G. Saad, Armando Mendez, Keith A. Webster, Jeffrey J. Goldberger, Joshua M. Hare, Lina A. Shehadeh
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 17 (2022)
Background The pathways of diastolic dysfunction and heart failure with preserved ejection fraction driven by lipotoxicity with metabolic syndrome are incompletely understood. Thus, there is an urgent need for animal models that accurately mimic the
Externí odkaz:
https://doaj.org/article/432212ebf6704b49a53ed9538b43891e
Autor:
Valentina Dargam, Hooi Hooi Ng, Sana Nasim, Daniel Chaparro, Camila Iansen Irion, Suhas Rathna Seshadri, Armando Barreto, Zachary C. Danziger, Lina A. Shehadeh, Joshua D. Hutcheson
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundCalcific aortic valve disease (CAVD) is often undiagnosed in asymptomatic patients, especially in underserved populations. Although artificial intelligence has improved murmur detection in auscultation exams, murmur manifestation depends on
Externí odkaz:
https://doaj.org/article/b3a8ac504ace4d16acb35e1c707cd4d2
Autor:
Camila I. Irion, Monique Williams, Jose Condor Capcha, Trevor Eisenberg, Guerline Lambert, Lauro M. Takeuchi, Grace Seo, Keyvan Yousefi, Rosemeire Kanashiro-Takeuchi, Keith A. Webster, Karen C. Young, Joshua M. Hare, Lina A. Shehadeh
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6674 (2022)
Alport syndrome (AS) is a hereditary renal disorder with no etiological therapy. In the preclinical Col4a3-/- model of AS, disease progression and severity vary depending on mouse strain. The sodium-glucose cotransporter 2 (SGLT2) is emerging as an a
Externí odkaz:
https://doaj.org/article/fbf60d0410904b11b6dde6632eeaf219
Autor:
Sung-Ting Chuang, Henrietta Papp, Anett Kuczmog, Rebecca Eells, Jose M. Condor Capcha, Lina A. Shehadeh, Ferenc Jakab, Peter Buchwald
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 621 (2022)
We have previously identified methylene blue, a tricyclic phenothiazine dye approved for clinical use for the treatment of methemoglobinemia and for other medical applications as a small-molecule inhibitor of the protein–protein interaction (PPI) b
Externí odkaz:
https://doaj.org/article/8868187349fc4584abc3edc950bc0ece
Autor:
Jose Manuel Condor Capcha, Guerline Lambert, Derek M. Dykxhoorn, Alessandro G. Salerno, Joshua M. Hare, Michael A. Whitt, Savita Pahwa, Dushyantha T. Jayaweera, Lina A. Shehadeh
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2021)
The COVID-19 pandemic caused by the SARS-CoV-2 coronavirus requires reliable assays for studying viral entry mechanisms which remains poorly understood. This knowledge is important for the development of therapeutic approaches to control SARS-CoV-2 i
Externí odkaz:
https://doaj.org/article/1f2f57c7537c4768944f2e70a6238ceb
Autor:
Mausam Patel, Daniela Rodriguez, Keyvan Yousefi, Krista John-Williams, Armando J. Mendez, Ronald B. Goldberg, Anastasios Lymperopoulos, Leonardo J. Tamariz, Jeffrey J. Goldberger, Robert J. Myerburg, Juhani Junttila, Lina A. Shehadeh
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
Background: Diabetes mellitus (DM) is associated with increased risk of sudden cardiac death (SCD), particularly in patients with heart failure with preserved ejection fraction (HFpEF). However, there are no known biomarkers in the population with DM
Externí odkaz:
https://doaj.org/article/b76e8fc3ec4142199460b3d0c6c4a50a