Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson’s disease

Autor: Lina A. Matschke, Marlene A. Komadowski, Annette Stöhr, Bolam Lee, Martin T. Henrich, Markus Griesbach, Susanne Rinné, Fanni F. Geibl, Wei-Hua Chiu, James B. Koprich, Jonathan M. Brotchie, Aytug K. Kiper, Amalia M. Dolga, Wolfgang H. Oertel, Niels Decher

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)

Abstract Parkinson’s disease (PD) is clinically defined by the presence of the cardinal motor symptoms, which are associated with a loss of dopaminergic nigrostriatal neurons in the substantia nigra pars compacta (SNpc). While SNpc neurons serve as

Externí odkaz: https://doaj.org/article/b4c64fe5027f4227873cb7742ebf70c7

Whole Exome Sequencing Identifies a Heterozygous Variant in the Cav1.3 Gene

Autor: Susanne, Rinné, Birgit, Stallmeyer, Alexandra, Pinggera, Michael F, Netter, Lina A, Matschke, Sven, Dittmann, Uwe, Kirchhefer, Ulrich, Neudorf, Joachim, Opp, Jörg, Striessnig, Niels, Decher, Eric, Schulze-Bahr

Publikováno v: International journal of molecular sciences. 23(22)

Cav1.3 voltage-gated L-type calcium channels (LTCCs) are involved in cardiac pacemaking, hearing and hormone secretion, but are also expressed postsynaptically in neurons. So far, homozygous loss of function mutations in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f72a5e5c5d63eef74d3ebe27428e2e7
https://pubmed.ncbi.nlm.nih.gov/36430690

The VAMP‐associated protein VAPB is required for cardiac and neuronal pacemaker channel function

Autor: Nicole, Silbernagel, Magdalena, Walecki, Martin K-H, Schäfer, Mirjam, Kessler, Mehrnoush, Zobeiri, Susanne, Rinné, Aytug K, Kiper, Marlene A, Komadowski, Kirsty S, Vowinkel, Konstantin, Wemhöner, Lisa, Fortmüller, Marcus, Schewe, Amalia M, Dolga, Jelena, Scekic-Zahirovic, Lina A, Matschke, Carsten, Culmsee, Thomas, Baukrowitz, Laurent, Monassier, Nina D, Ullrich, Luc, Dupuis, Steffen, Just, Thomas, Budde, Larissa, Fabritz, Niels, Decher

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2018, 32 (11), pp.6159-6173. ⟨10.1096/fj.201800246R⟩
FASEB Journal, 2018, 32 (11), pp.6159-6173. ⟨10.1096/fj.201800246R⟩
The FASEB Journal

International audience; Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels encode neuronal and cardiac pacemaker currents. The composition of pacemaker channel complexes in different tissues is poorly understood, and the presence of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e755c95be78f366a4d454f8d49fa2312
https://www.hal.inserm.fr/inserm-03376145/document

A concerted action of L- and T-type Ca2+ channels regulates locus coeruleus pacemaking

Autor: Niels Decher, Jochen Roeper, Lina A Matschke, Terrance P. Snutch, Wolfgang H. Oertel, Mirjam Bertoune, Susanne Rinné

Publikováno v: Molecular and Cellular Neuroscience. 68:293-302

Dysfunction of noradrenergic locus coeruleus (LC) neurons is involved in psychiatric and neurodegenerative diseases and is an early hallmark of Parkinson's disease (PD). The analysis of ion channels underlying the autonomous electrical activity of LC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4939f200851a9f2588b8154e6a93b1d9
https://doi.org/10.1016/j.mcn.2015.08.012

SK2 channels regulate mitochondrial respiration and mitochondrial Ca2+ uptake

Autor: Albert Gerding, Carsten Culmsee, Niels Decher, Birgit Honrath, Lena Magerhans, Tammo Meyer, Hans Zischka, Amalia M. Dolga, Cornelius Krasel, Barbara M. Bakker, Lina A Matschke, Fabiana Perocchi, Stefan Strack, Goutham K. Ganjam, Moritz Bünemann

Publikováno v: Cell Death Differ. 24, 761-773 (2017)
Cell death and differentiation, 24(5), 761-773. Nature Publishing Group

Mitochondrial calcium ([Ca(2+)]m) overload and changes in mitochondrial metabolism are key players in neuronal death. Small conductance calcium-activated potassium (SK) channels provide protection in different paradigms of neuronal cell death. Recent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1cf39d0fd3deebdb415573cb7eb0789
https://europepmc.org/articles/PMC5423111/