Internet-delivered cognitive behavioral therapy (iCBT) for common mental disorders and subsequent sickness absence: a systematic review and meta-analysis

Autor: Lina Udd-granat, Jouni Lahti, Michael Donnelly, Charlene Treanor, Sami P. Pirkola, Tea Lallukka, Anne Kouvonen

Publikováno v: Udd-Granat, L, Lahti, J, Donnelly, M, Treanor, C, Pirkola, S P, Lallukka, T & Kouvonen, A 2022, ' Internet-delivered cognitive behavioral therapy (iCBT) for common mental disorders and subsequent sickness absence: a systematic review and meta-analysis ', Scandinavian journal of public health, vol. 50, no. 1 . https://doi.org/10.1177/14034948221075016
Udd-granat, L, Lahti, J, Donnelly, M, Treanor, C, Pirkola, S P, Lallukka, T & Kouvonen, A 2022, ' Internet-delivered cognitive behavioral therapy (iCBT) for common mental disorders and subsequent sickness absence: a systematic review and meta-analysis ', Scandanavian Journal of Public Health . https://doi.org/10.1177/14034948221075016

Aim: The study aimed to critically review and synthesize the best available evidence about the effectiveness of therapist-guided internet-delivered cognitive behavioral therapy (iCBT) in terms of reducing sickness absence (SA). Methods: We searched M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78e5d3a73e8130aff282c4d8389f7a9
https://pure.qub.ac.uk/en/publications/internetdelivered-cognitive-behavioral-therapy-icbt-for-common-mental-disorders-and-subsequent-sickness-absence-a-systematic-review-and-metaanalysis(7e43add2-2d12-4874-8494-f2ebf2016d8b).html

The LKB1 tumor suppressor kinase in human disease

Autor: Tea Vallenius, Lina Udd, Kari Vaahtomeri, Tomi P. Mäkelä, Marianne Tiainen, Pekka Katajisto, Niklas Ekman

Publikováno v: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1775:63-75

Inactivating germline mutations in the LKB1 gene underlie Peutz-Jeghers syndrome characterized by hamartomatous polyps and an elevated risk for cancer. Recent studies suggest the involvement of LKB1 also in more common human disorders including diabe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285a49096db1322a7014b3e10934ff0f
https://doi.org/10.1016/j.bbcan.2006.08.003

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

Autor: Lina Udd, Jérôme Boudeau, Jose M. Lizcano, Simon A. Hawley, Olga Göransson, Rachel Toth, Tomi P. Mäkelä, Dario R. Alessi, D. Grahame Hardie, Maria Deak, Nick A. Morrice

Publikováno v: The EMBO Journal. 23:833-843

We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP-activated protein kinase (AMPK). A total of 12 human kinases (NUAK1, NUAK2, BRS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d7c6b8989476f0f9469a719cd8c233
https://doi.org/10.1038/sj.emboj.7600110

N-methylnitrosourea aggravates gastrointestinal polyposis in Lkb1+/- mice

Autor: Tomi P. Mäkelä, Lina Udd, Ari Ristimäki, Yajing Gao

Publikováno v: Carcinogenesis. 34(10)

Peutz-Jeghers patients develop hamartomatous polyps and carcinomas of the gastrointestinal tract. Cyclooxygenase-2 accelerates polyp growth in Lkb1 (+/-) mice modelling Peutz-Jeghers polyposis. In this study, we aimed to evaluate the effect of the mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82112c093099d863c0027a60dd638897
https://pubmed.ncbi.nlm.nih.gov/23722652

Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2

Autor: Derrick J. Rossi, Ari Ristimäki, Lina Udd, Antti Ylikorkala, Heikki Järvinen, Pekka Katajisto, Anna—Maria Lahesmaa, Anna Lepistö, Tomi P. Mäkelä

Publikováno v: Gastroenterology. 127(4)

Background & Aims: Peutz—Jeghers syndrome (PJS) is typically manifested as severe gastrointestinal polyposis. Polyps in PJS patients and in Lkb1 +/− mice that model PJS polyposis are frequently characterized by elevated cyclooxygenase-2 (COX-2).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d80dff988bc0d465f7c5b08aa6ef986
https://pubmed.ncbi.nlm.nih.gov/15480979