Membrane estrogen receptor α signaling modulates the sensitivity to estradiol treatment in a dose- and tissue- dependent manner

Autor: Yiwen Jiang, Karin Horkeby, Petra Henning, Jianyao Wu, Lina Lawenius, Cecilia Engdahl, Priti Gupta, Sofia Movérare-Skrtic, Karin H. Nilsson, Ellis Levin, Claes Ohlsson, Marie K. Lagerquist

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)

Abstract Estradiol (E2) affects both reproductive and non-reproductive tissues, and the sensitivity to different doses of E2 varies between tissues. Membrane estrogen receptor α (mERα)-initiated signaling plays a tissue-specific role in mediating E

Externí odkaz: https://doaj.org/article/d2771fc646b5432c9142e280d23828b5

Reduction of Mature B Cells and Immunoglobulins Results in Increased Trabecular Bone

Autor: Marie K. Lagerquist, Priti Gupta, Edina Sehic, Karin L. Horkeby, Julia M. Scheffler, Jauquline Nordqvist, Lina Lawenius, Ulrika Islander, Carmen Corciulo, Petra Henning, Hans Carlsten, Cecilia Engdahl

Publikováno v: JBMR Plus, Vol 6, Iss 9, Pp n/a-n/a (2022)

ABSTRACT Inflammation has a significant effect on bone remodeling and can result in bone loss via increased stimulation of osteoclasts. Activated immunoglobulins, especially autoantibodies, can increase osteoclastogenesis and are associated with path

Externí odkaz: https://doaj.org/article/c8816c3fc0974aba9be50b47d700ee86

Development of a synbiotic that protects against ovariectomy-induced trabecular bone loss

Autor: Lina Lawenius, Karin L. Gustafsson, Jianyao Wu, Karin H. Nilsson, Sofia Movérare-Skrtic, Eric M. Schott, Maria J. Soto-Girón, Gerardo V. Toledo, Klara Sjögren, Claes Ohlsson

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 322:E344-E354

The gut microbiome has the capacity to regulate bone mass. The aim of this study was to develop a nutritional synbiotic dietary assemblage at an optimal dose to maintain bone mass in ovariectomized (Ovx) mice. We performed genomic analyses and in vit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d29f0cdbe5a29814f58dc5e1fd2a9ae
https://doi.org/10.1152/ajpendo.00366.2021

Bone and the microbiome

Autor: Klara Sjögren, Claes Ohlsson, Lina Lawenius, Roberto Pacifici

Publikováno v: Marcus and Feldman's Osteoporosis ISBN: 9780128130735

The gut microbiota (GM) could be regarded as a separate highly metabolic active organ harboring many more genes than the human genome and, in contrast to the human genome, the microbiome is adapting rapidly to environmental changes. Animal studies us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5b51eb9e6507f1c18755a985578cbff
https://doi.org/10.1016/b978-0-12-813073-5.00039-3

Pasteurized Akkermansia muciniphila protects from fat mass gain but not from bone loss

Autor: Julia M. Scheffler, Hubert Plovier, Patrice D. Cani, Ulrika Islander, Lina Lawenius, Willem M. de Vos, Klara Sjögren, Petra Henning, Karin H Nilsson, Hannah Colldén, Claes Ohlsson, Karin Gustafsson

Publikováno v: American Journal of Physiology. Endocrinology and Metabolism, 318(4), E480-E491
American Journal of Physiology. Endocrinology and Metabolism 318 (2020) 4
American Journal of Physiology-Endocrinology and Metabolism, Vol. 318, no.4, p. E480-E491 (2020)

Probiotic bacteria can protect from ovariectomy (ovx)-induced bone loss in mice. Akkermansia muciniphila is considered to have probiotic potential due to its beneficial effect on obesity and insulin resistance. The purpose of the present study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8a16eb42bc2a5bd189924162e54169
http://hdl.handle.net/10138/326336