Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Lin-Xia Zhao"'
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2309 (2023)
The use of nanomaterials in drug delivery systems for pain treatment is becoming increasingly common. This review aims to summarize how nanomaterial-based drug delivery systems can be used to effectively treat and relieve pain, whether via the delive
Externí odkaz:
https://doaj.org/article/2713a8c423fe4b5892d7f535de2ba8dd
Autor:
Yan Zhang, Hao Gong, Ji-Shuai Wang, Meng-Na Li, De-Li Cao, Jun Gu, Lin-Xia Zhao, Xin-Dan Zhang, Yu-Tao Deng, Fu-Lu Dong, Yong-Jing Gao, Wen-Xing Sun, Bao-Chun Jiang
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10148 (2023)
Phosphorylation of the serine 139 of the histone variant H2AX (γH2AX) is a DNA damage marker that regulates DNA damage response and various diseases. However, whether γH2AX is involved in neuropathic pain is still unclear. We found the expression o
Externí odkaz:
https://doaj.org/article/5877d149f6b04da0ae8bda7ac5bf8d62
Autor:
Gang Chen, Rou-Gang Xie, Yong-Jing Gao, Zhen-Zhong Xu, Lin-Xia Zhao, Sangsu Bang, Temugin Berta, Chul-Kyu Park, Mark Lay, Wei Chen, Ru-Rong Ji
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The cellular mechanisms underlying acute pain transitions to chronic pain are poorly understood. Here the authors show that the scaffolding protein β-arrestin 2 contributes to these processes via desensitization of NMDA receptors in spinal neurons.
Externí odkaz:
https://doaj.org/article/d71d3fc96fe3477b80fc968a12f53cb5
Autor:
Jiang, Yan Zhang, Hao Gong, Ji-Shuai Wang, Meng-Na Li, De-Li Cao, Jun Gu, Lin-Xia Zhao, Xin-Dan Zhang, Yu-Tao Deng, Fu-Lu Dong, Yong-Jing Gao, Wen-Xing Sun, Bao-Chun
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 10148
Phosphorylation of the serine 139 of the histone variant H2AX (γH2AX) is a DNA damage marker that regulates DNA damage response and various diseases. However, whether γH2AX is involved in neuropathic pain is still unclear. We found the expression o
Autor:
Ming Jiang, De-Li Cao, Yong-Jing Gao, Tong-Tong Chen, Lin-Xia Zhao, Xue-Qiang Bai, Zhi-Jun Zhang, Juan Wang, Jing Zhang, Hao Wu, Jian-Shuang Guo, Xiao-Bo Wu
Publikováno v:
Neuroscience Bulletin
Trigeminal neuropathic pain (TNP) is a significant health problem but the involved mechanism has not been completely elucidated. Toll-like receptors (TLRs) have recently been demonstrated to be expressed in the dorsal root ganglion and involved in ch
Autor:
Lin-Xia Zhao, Xue-Qiang Bai, De-Li Cao, Xiao-Bo Wu, Ming Jiang, Jing Zhang, Jian-Shuang Guo, Tong-Tong Chen, Hao Wu, Yong-Jing Gao, Zhi-Jun Zhang
Background: Trigeminal neuropathic pain (TNP) is a significant health problem whereas the involved mechanism has not been completely elucidated. Toll-like receptors (TLRs) are recently demonstrated to be expressed in the dorsal root ganglion and invo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4665c225943aa87c7de1daa11e8f3d64
https://doi.org/10.21203/rs.2.24451/v1
https://doi.org/10.21203/rs.2.24451/v1
Publikováno v:
Neurosci Bull
Chemokines and receptors have been implicated in the pathogenesis of chronic pain. Here, we report that spinal nerve ligation (SNL) increased CXCR3 expression in dorsal root ganglion (DRG) neurons, and intra-DRG injection of Cxcr3 shRNA attenuated th
Publikováno v:
Cellular and Molecular Neurobiology. 36:143-149
Ligustilide is a major component of Radix Angelica Sinensis and reported to have anti-inflammatory and anti-nociceptive effects. Toll-like receptor 4 (TLR4) has been shown to be expressed in the spinal cord and be involved in inflammatory pain and ne
Publikováno v:
Brain research bulletin. 135
Visceral hypersensitivity induced by inflammatory bowel disease (IBD) is a clinical challenge since the underlying mechanisms remain elusive. Chemokines and their receptors have been suggested to modulate inflammatory pain and neuropathic pain. How
Publikováno v:
Brain Research Bulletin. 109:54-60
Ligustilide is the main component of Danggui essential oil, and recently reported to have anti-inflammatory and neuroprotective effect. Increasing evidence suggests that glia-mediated neuroinflammation in the spinal cord plays a vital role in the pat