In vitro and in silico studies of bis (indol-3-yl) methane derivatives as potential α-glucosidase and α-amylase inhibitors

Autor: Xin Zhang, Mei Feng, Lin-Sheng Lei, Xue-Tao Xu, Peng-Fei Zheng, Jing Lin, Xiao-Zheng Wu, Cui-ying Liao, Shao-Hua Wang, You-Cheng Zhang, Zhuang Xiong

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1938-1951 (2021)
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record

In this paper, bis (indol-3-yl) methanes (BIMs) were synthesised and evaluated for their inhibitory activity against α-glucosidase and α-amylase. All synthesised compounds showed potential α-glucosidase and α-amylase inhibitory activities. Compou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20345973742b84fce8793aa4f2564fc5
https://doaj.org/article/2fde9f14d73e494daa4d6eb8a3c3078b

The synthesis of cyanoformamides via a CsF-promoted decyanation/oxidation cascade of 2-dialkylamino-malononitriles

Autor: Lin-Sheng Lei, Wen Bao, Cao-Gen Xue, Abdullah M. Asiri, Shao-Hua Wang, Kun Zhang, Da-Ping Jin, Huan Liang, Xue-Tao Xu

Publikováno v: Organic & Biomolecular Chemistry. 17:3723-3726

A mild and efficient method for the synthesis of cyanoformamides from N,N-disubstituted aminomalononitriles with CsF as the promoter has been developed. This method features a wide substrate scope and high reaction efficiency, and will facilitate cor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f2fb6486bacd47a4d26c5f8778aa43
https://doi.org/10.1039/c9ob00510b

A catalytic asymmetric one-pot [3+2] cyclization/semipinacol rearrangement sequence: an efficient construction of a multi-substituted 3H-spiro[benzofuran-2,1'-cyclopentane] skeleton

Autor: Fu-Min Zhang, Ai-Jun Ma, Yong-Qiang Tu, Lin-Sheng Lei, Si-Zhan Liu, Shao-Hua Wang, Xiao-Ming Zhang, Lin Liu, Zong-Song Zhan, Yu-Xiao Wang

Publikováno v: Chemical communications (Cambridge, England). 55(26)

A facile and efficient method to form a chiral multi-substituted 3H-spiro[benzofuran-2,1′-cyclopentane] structural unit has been developed via a one-pot [3+2] cyclization/semipinacol rearrangement cascade. A catalysis system of Cu(II)/BOX has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d228e42f347d01357e0abe5e87c7d3
https://pubmed.ncbi.nlm.nih.gov/30864584

Copper-catalyzed cyclization of 2-cyanobenzaldehydes and 2-isocyanoacetates: an efficient strategy for the synthesis of substituted 1-aminoisoquinolines

Autor: Jun-Qi Wang, Wen Bao, Lin-Sheng Lei, Wei-Ting Liu, Xue-Tao Xu, Huan Liang, Bang-Hong Zhang, Kun Zhang, Shao-Hua Wang

Publikováno v: Chemical communications (Cambridge, England). 54(59)

A Cu(acac)2-catalyzed cyclization reaction of 2-cyanobenzaldehydes with 2-isocyanoacetates has been successfully developed providing an efficient strategy for the synthesis of substituted 1-aminoisoquinolines. The reaction proceeds smoothly under mil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ed2cdfcf8e05595c925376e8056639
https://pubmed.ncbi.nlm.nih.gov/29975389

Cyclooxygenase-2 gene silence induces apoptosis of human hepatocellular carcinoma cells

Autor: Dan GUO, Na-na CHEN, Shu-guang WU, Lin-sheng LEI

Publikováno v: Medical Journal of Chinese People's Liberation Army, Vol 37, Iss 7, Pp 545-549 (2012)

Objective To specifically silence COX-2 gene expression in cultured human hepatocellular carcinoma cells HepG2 by construction and transfection of COX-2 hairpin RNA (shRNA) expression vectors, and investigate the effects of knocking COX-2 down on cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::34392793b1eb6baf2cfe43621abeaf20
http://www.plamj.org/index.php/plamj/article/view/517