Suite of Biochemical and Cell-Based Assays for the Characterization of Kirsten Rat Sarcoma (KRAS) Inhibitors and Degraders.

Autor: Kidane M; Research and Development and Technology Transfer, Eurofins DiscoverX, LLC, 11180 Roselle Street Suite D, San Diego, California 92121, United States., Hoffman RM; Research and Development, Eurofins DiscoverX Products, LLC, 42501 Albrae Street, Fremont, California 94538, United States., Wolfe-Demarco JK; Research and Development and Technology Transfer, Eurofins DiscoverX, LLC, 11180 Roselle Street Suite D, San Diego, California 92121, United States., Huang TY; Eurofins Panlabs Discovery Services Taiwan, Ltd., 25 Wugong Sixth Road, Wugu District, New Taipei City 24891, Taiwan., Teng CL; Eurofins Panlabs Discovery Services Taiwan, Ltd., 25 Wugong Sixth Road, Wugu District, New Taipei City 24891, Taiwan., Samanta S; Research and Development, Eurofins DiscoverX Products, LLC, 42501 Albrae Street, Fremont, California 94538, United States., Gonzalez Lira LM; Research and Development and Technology Transfer, Eurofins DiscoverX, LLC, 11180 Roselle Street Suite D, San Diego, California 92121, United States., Lin-Jones J; Research and Development, Eurofins DiscoverX Products, LLC, 42501 Albrae Street, Fremont, California 94538, United States., Pallares G; Research and Development and Technology Transfer, Eurofins DiscoverX, LLC, 11180 Roselle Street Suite D, San Diego, California 92121, United States., Lamerdin JE; Research and Development, Eurofins DiscoverX Products, LLC, 42501 Albrae Street, Fremont, California 94538, United States., Servant NB; Research and Development and Technology Transfer, Eurofins DiscoverX, LLC, 11180 Roselle Street Suite D, San Diego, California 92121, United States., Lee CY; Eurofins Panlabs Discovery Services Taiwan, Ltd., 25 Wugong Sixth Road, Wugu District, New Taipei City 24891, Taiwan., Yang CT; Research and Development, Eurofins DiscoverX Products, LLC, 42501 Albrae Street, Fremont, California 94538, United States., Bernatchez JA; Research and Development and Technology Transfer, Eurofins DiscoverX, LLC, 11180 Roselle Street Suite D, San Diego, California 92121, United States.

Publikováno v: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2024 Dec 02; Vol. 7 (12), pp. 3921-3934. Date of Electronic Publication: 2024 Dec 02 (Print Publication: 2024).

Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3).

Autor: Kaniskan HÜ; Center for Chemical Biology and Drug Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States., Eram MS; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada., Zhao K; Novartis Institutes for Biomedical Research (China), Zhangjiang Hi-Tech Park , Pudong New Area, Shanghai 201203, China., Szewczyk MM; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada., Yang X; Center for Chemical Biology and Drug Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States., Schmidt K; Center for Chemical Biology and Drug Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States., Luo X; Novartis Institutes for Biomedical Research (China), Zhangjiang Hi-Tech Park , Pudong New Area, Shanghai 201203, China., Xiao S; Novartis Institutes for Biomedical Research (China), Zhangjiang Hi-Tech Park , Pudong New Area, Shanghai 201203, China., Dai M; Novartis Institutes for Biomedical Research (China), Zhangjiang Hi-Tech Park , Pudong New Area, Shanghai 201203, China., He F; Novartis Institutes for Biomedical Research (China), Zhangjiang Hi-Tech Park , Pudong New Area, Shanghai 201203, China., Zang I; Novartis Institutes for Biomedical Research (China), Zhangjiang Hi-Tech Park , Pudong New Area, Shanghai 201203, China., Lin Y; Novartis Institutes for Biomedical Research (China), Zhangjiang Hi-Tech Park , Pudong New Area, Shanghai 201203, China., Li F; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada., Dobrovetsky E; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada., Smil D; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada., Min SJ; Center for Chemical Biology and Drug Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States., Lin-Jones J; DiscoveRx Corporation , Fremont, California 94538, United States., Schapira M; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada.; Department of Pharmacology and Toxicology, University of Toronto , Toronto, ON M5S 1A8, Canada., Atadja P; Novartis Institutes for Biomedical Research (China), Zhangjiang Hi-Tech Park , Pudong New Area, Shanghai 201203, China., Li E; Novartis Institutes for Biomedical Research (China), Zhangjiang Hi-Tech Park , Pudong New Area, Shanghai 201203, China., Barsyte-Lovejoy D; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada., Arrowsmith CH; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada.; Department of Medical Biophysics, University of Toronto and Princess Margaret Cancer Centre , 101 College Street, MaRS South Tower, Suite 707, Toronto, ON M5G 1L7, Canada., Brown PJ; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada., Liu F; Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Soochow University , Suzhou, Jiangsu 215123, China., Yu Z; Novartis Institutes for Biomedical Research (China), Zhangjiang Hi-Tech Park , Pudong New Area, Shanghai 201203, China., Vedadi M; Structural Genomics Consortium, University of Toronto , Toronto, ON M5G 1L7, Canada.; Department of Pharmacology and Toxicology, University of Toronto , Toronto, ON M5S 1A8, Canada., Jin J; Center for Chemical Biology and Drug Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Feb 08; Vol. 61 (3), pp. 1204-1217. Date of Electronic Publication: 2018 Jan 05.

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Fascin 2b is a component of stereocilia that lengthens actin-based protrusions.

Autor: Chou SW; Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Hwang P, Gomez G, Fernando CA, West MC, Pollock LM, Lin-Jones J, Burnside B, McDermott BM Jr

Publikováno v: PloS one [PLoS One] 2011; Vol. 6 (4), pp. e14807. Date of Electronic Publication: 2011 Apr 26.