Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Lin Y. Xie"'
Autor:
Thomas L. Campbell, Lin Y. Xie, Ralen H. Johnson, Christina M. Hultman, Edwin J. C. G. van den Oord, Karolina A. Aberg
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-8 (2024)
Abstract Adverse neonatal outcomes are a prevailing risk factor for both short- and long-term mortality and morbidity in infants. Given the importance of these outcomes, refining their assessment is paramount for improving prevention and care. Here w
Externí odkaz:
https://doaj.org/article/38c33bf8cd734436a0b6c0a9172b0c7e
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-9 (2021)
Abstract Background To avoid false-positive findings and detect cell-type specific associations in methylation and transcription investigations with bulk samples, it is critical to know the proportions of the major cell-types. Results We present a no
Externí odkaz:
https://doaj.org/article/5c00df12d99840e9bb04d3d5e34fa68f
Autor:
Karolina A. Aberg, Robin F. Chan, Andrey A. Shabalin, Min Zhao, Gustavo Turecki, Nicklas Heine Staunstrup, Anna Starnawska, Ole Mors, Lin Y. Xie, Edwin JCG van den Oord
Publikováno v:
Epigenetics, Vol 12, Iss 9, Pp 743-750 (2017)
We recently showed that, after optimization, our methyl-CpG binding domain sequencing (MBD-seq) application approximates the methylome-wide coverage obtained with whole-genome bisulfite sequencing (WGB-seq), but at a cost that enables adequately powe
Externí odkaz:
https://doaj.org/article/97145fdd83d9488bb768c3b9fc166d09
Autor:
Edwin J. C. G. van den Oord, Lin Y. Xie, Min Zhao, Thomas L. Campbell, Gustavo Turecki, Anna K. Kähler, Brian Dean, Ole Mors, Christina M. Hultman, Nicklas H. Staunstrup, Karolina A. Aberg
Publikováno v:
van den Oord, E J C G, Xie, L Y, Zhao, M, Campbell, T L, Turecki, G, Kähler, A K, Dean, B, Mors, O, Hultman, C M, Staunstrup, N H & Aberg, K A 2023, ' Genes implicated by a methylome-wide schizophrenia study in neonatal blood show differential expression in adult brain samples ', Molecular Psychiatry . https://doi.org/10.1038/s41380-023-02080-5
Schizophrenia is a disabling disorder involving genetic predisposition in combination with environmental influences that likely act via dynamic alterations of the epigenome and the transcriptome but its detailed pathophysiology is largely unknown. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4485538c9e98e8b886dd7588973f62
https://doi.org/10.1038/s41380-023-02080-5
https://doi.org/10.1038/s41380-023-02080-5
Publikováno v:
Addiction Biology. 28
Gene expression studies offer promising opportunities to better understand the processes underlying alcohol use disorder (AUD). As cell types differ in their function, gene expression profiles will typically vary across cell types. When studying bulk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24049677d7f8d984617fb9968b29fe62
https://doi.org/10.1111/adb.13250
https://doi.org/10.1111/adb.13250
Alcohol use disorder (AUD) is a significant public health problem. Gene expression studies offer promising opportunities to better understand the underlying pathogenic processes. As cell-types differ in their function, gene expression profiles will t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f33ed67580d0aa6c79d0546af94f7aa
https://doi.org/10.1101/2022.06.16.22272431
https://doi.org/10.1101/2022.06.16.22272431
Autor:
William E. Copeland, Brenda W.J.H. Penninx, Lin Y. Xie, Edwin J. C. G. van den Oord, Shaunna L. Clark, Robin F. Chan, Min Zhao, Karolina A. Aberg
Publikováno v:
Addict Biol
Clark, S L, Chan, R F, Zhao, M, Xie, L Y, Copeland, W E, Penninx, B W J H, Aberg, K A & van den Oord, E J C G 2022, ' Dual methylation and hydroxymethylation study of alcohol use disorder ', Addiction Biology, vol. 27, no. 2, e13114 . https://doi.org/10.1111/adb.13114
Addiction Biology, 27(2):e13114. Wiley-Blackwell
Clark, S L, Chan, R F, Zhao, M, Xie, L Y, Copeland, W E, Penninx, B W J H, Aberg, K A & van den Oord, E J C G 2022, ' Dual methylation and hydroxymethylation study of alcohol use disorder ', Addiction Biology, vol. 27, no. 2, e13114 . https://doi.org/10.1111/adb.13114
Addiction Biology, 27(2):e13114. Wiley-Blackwell
Background: Using a three-stage, multi-tissue design we sought to characterize methylation and hydroxymethylation changes in blood and brain associated with alcohol use disorder (AUD). Methods: In the discovery stage, we used epigenomic deconvolution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be07b82be1f196d19c1c4bab97033711
https://doi.org/10.1111/adb.13114
https://doi.org/10.1111/adb.13114
Publikováno v:
BMC Bioinformatics
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-9 (2021)
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-9 (2021)
Background To avoid false-positive findings and detect cell-type specific associations in methylation and transcription investigations with bulk samples, it is critical to know the proportions of the major cell-types. Results We present a novel appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05845bf7e9dab3add89521af983841fa
http://europepmc.org/articles/PMC8474864
http://europepmc.org/articles/PMC8474864
Autor:
Robin F. Chan, William E. Copeland, Edwin J. C. G. van den Oord, Karolina A. Aberg, Lin Y. Xie, Shaunna L. Clark, Min Zhao
Publikováno v:
J Am Acad Child Adolesc Psychiatry
Objective The impact of adolescent cannabis use is a pressing public health question owing to the high rates of use and links to negative outcomes. This study considered the association between problematic adolescent cannabis use and methylation. Met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eab68e82ab99ff43b6dc676a073a0d4
https://pubmed.ncbi.nlm.nih.gov/33631312
https://pubmed.ncbi.nlm.nih.gov/33631312
Autor:
Philip M. Gerk, Fay M. Jahr, Karolina A. Aberg, Mikhail G. Dozmorov, Elvin T. Price, Patricia W. Slattum, Palak S. Phansalkar, Joseph L. McClay, Mohamad M. Kronfol, Lin Y. Xie, MaryPeace McRae
Publikováno v:
GeroScience
Aging is associated with reduced liver function that may increase the risk for adverse drug reactions in older adults. We hypothesized that age-related changes to epigenetic regulation of genes involved in drug metabolism may contribute to this effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca38b3d3f8e787cfdcfca42b30e5390
https://pubmed.ncbi.nlm.nih.gov/32221779
https://pubmed.ncbi.nlm.nih.gov/32221779