Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lin Rigby"'
Autor:
David M. Ashley, Grant A. McArthur, Michael Michael, Melissa J Ferguson, Andrea Muscat, Robyn Strong, Paul Wood, Lin Rigby, Elizabeth Algar
Publikováno v:
Cancer chemotherapy and pharmacology. 82(3)
This was an open label, phase I (3 + 3 design), multi-centre study evaluating panobinostat in pediatric patients with refractory solid tumors. Primary endpoints were to establish MTD, define and describe associated toxicities, including dose limiting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf47f1b5e9e9af60decd339fc85d983
https://pubmed.ncbi.nlm.nih.gov/29987369
https://pubmed.ncbi.nlm.nih.gov/29987369
Publikováno v:
Epigenetics. 7:875-882
LBH589 is one of the many histone deacetylase inhibitors (HDACi) that are currently in clinical trial. Despite their wide-spread use, there is little literature available describing the typical levels of histone acetylation in untreated peripheral bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61fa468b3528166fe025a70b976a31fe
https://doi.org/10.4161/epi.20983
https://doi.org/10.4161/epi.20983
Publikováno v:
Clinical Journal of the American Society of Nephrology. 5:34-38
Background and objectives: Previous studies of X-linked Alport syndrome demonstrated that “severe” COL4A5 mutations (large deletions and rearrangements, nonsense and frame-shift mutations, and glycine substitutions in the carboxy-terminal residue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043541c4d38ad29676d39817c5cb1c6b
https://doi.org/10.2215/cjn.01030209
https://doi.org/10.2215/cjn.01030209
Autor:
Diane Wilson, Yan Yan Wang, Tania Tabone, Richard G.H. Cotton, Stephen Tonna, Lin Rigby, Judy Savige
Publikováno v:
Pediatric Nephrology. 23:2201-2207
Thin-basement-membrane nephropathy (TBMN) is characterized by persistent dysmorphic hematuria, and the presence of proteinuria is a risk factor for renal impairment. TBMN is often due to mutations in the COL4A3 and COL4A4 genes, and this study determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d510dbb7f802da040ec5ec225fe432dd
https://doi.org/10.1007/s00467-008-0934-7
https://doi.org/10.1007/s00467-008-0934-7
Autor:
Michael Michael, Lin Rigby, Grant A. McArthur, Robyn Strong, Paul Wood, Elizabeth M. Algar, David M. Ashley, Andrea Muscat
Publikováno v:
Journal of Clinical Oncology. 32:10061-10061
10061 Background: Deregulated acetylation of histones plays a key role in the pathogenesis of haematological and solid tumors by changing the transcription of genes involved in cell cycle control, ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4dffb8a96b548c8aaa26b1cf09cb4d8
https://doi.org/10.1200/jco.2014.32.15_suppl.10061
https://doi.org/10.1200/jco.2014.32.15_suppl.10061
Autor:
David M. Ashley, David Thomas, Christopher D. Riffkin, Lavinia Gordon, Dean Popovski, Elizabeth M. Algar, Anissa Jabbour, Lin Rigby, Paul G Ekert, Pratiti Bandopadhayay, David N. Watkins, Marika Salmanidis
Publikováno v:
BMC Cancer
Background Desmoplastic small round cell tumor (DSRCT) is characterized by the presence of a fusion protein EWS/WT1, arising from the t (11;22) (p13;q12) translocation. Here we examine the oncogenic properties of two splice variants of EWS/WT1, EWS/W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9ef2725880cecd27b89a77f9e70e81a