Výsledky vyhledávání - "Lin L, Mantell"

Akademický článek

A Standardized Botanical Composition Mitigated Acute Inflammatory Lung Injury and Reduced Mortality through Extracellular HMGB1 Reduction

Autor: Mesfin Yimam, Teresa Horm, Alexandria O’Neal, Ping Jiao, Mei Hong, Lidia Brownell, Qi Jia, Mosi Lin, Alex Gauthier, Jiaqi Wu, Kranti Venkat Mateti, Xiaojian Yang, Katelyn Dial, Sidorela Zefi, Lin L. Mantell

Publikováno v: Molecules, Vol 28, Iss 18, p 6560 (2023)

HMGB1 is a key late inflammatory mediator upregulated during air-pollution-induced oxidative stress. Extracellular HMGB1 accumulation in the airways and lungs plays a significant role in the pathogenesis of inflammatory lung injury. Decreasing extrac

Externí odkaz: https://doaj.org/article/dd814b9fca4c4bbcb37f0f97fe0a2931

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Akademický článek

2-O, 3-O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1-compromised macrophage function

Autor: Mao Wang, Alex G. Gauthier, Thomas P. Kennedy, Haichao Wang, Uday Kiran Velagapudi, Tanaji T. Talele, Mosi Lin, Jiaqi Wu, LeeAnne Daley, Xiaojing Yang, Vivek Patel, Sung Soo Mun, Charles R. Ashby, Lin L. Mantell

Publikováno v: Molecular Medicine, Vol 27, Iss 1, Pp 1-17 (2021)

Abstract Background High mobility group box 1 protein (HMGB1) is an alarmin following its release by immune cells upon cellular activation or stress. High levels of extracellular HMGB1 play a critical role in impairing the clearance of invading pulmo

Externí odkaz: https://doaj.org/article/751de7d9c34541a58841dbf2cd260d81

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Akademický článek

From nicotine to the cholinergic anti-inflammatory reflex – Can nicotine alleviate the dysregulated inflammation in COVID-19?

Autor: Alex G. Gauthier, Mosi Lin, Jiaqi Wu, Thomas P. Kennedy, Lee-Anne Daley, Charles R. Ashby, Lin L. Mantell

Publikováno v: Journal of Immunotoxicology, Vol 18, Iss 1, Pp 23-29 (2021)

The coronavirus SARS-CoV-2 of 2019 (COVID-19) causes a pandemic that has been diagnosed in more than 70 million people worldwide. Mild-to-moderate COVID-19 symptoms include coughing, fever, myalgia, shortness of breath, and acute inflammatory lung in

Externí odkaz: https://doaj.org/article/3509f4ef45424e97a129709812198ef6

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Akademický článek

The α7 nicotinic acetylcholine receptor agonist GTS-21 improves bacterial clearance in mice by restoring hyperoxia-compromised macrophage function

Autor: Ravikumar A. Sitapara, Alex G. Gauthier, Vivek S. Patel, Mosi Lin, Michelle Zur, Charles R. Ashby, Lin L. Mantell

Publikováno v: Molecular Medicine, Vol 26, Iss 1, Pp 1-13 (2020)

Abstract Background Mechanical ventilation, in combination with supraphysiological concentrations of oxygen (i.e., hyperoxia), is routinely used to treat patients with respiratory distress, such as COVID-19. However, prolonged exposure to hyperoxia c

Externí odkaz: https://doaj.org/article/06e6f460ddf3479f99cc4617353a4274

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Akademický článek

The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation

Autor: Ravikumar A. Sitapara, Alex G. Gauthier, Sergio I. Valdés-Ferrer, Mosi Lin, Vivek Patel, Mao Wang, Ashley T. Martino, Jeanette C. Perron, Charles R. Ashby, Kevin J. Tracey, Valentin A. Pavlov, Lin L. Mantell

Publikováno v: Molecular Medicine, Vol 26, Iss 1, Pp 1-12 (2020)

Abstract Background Oxygen therapy, using supraphysiological concentrations of oxygen (hyperoxia), is routinely administered to patients who require respiratory support including mechanical ventilation (MV). However, prolonged exposure to hyperoxia r

Externí odkaz: https://doaj.org/article/b13b623bd7544973bd280f95bda287a6

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