Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Lin Hua Zhang"'
Autor:
Si-Yue Yu, Tiffany Carlaw, Tyler Thomson, Alexandra Birkenshaw, Genc Basha, Daniel Kurek, Cassie Huang, Jayesh Kulkarni, Lin-Hua Zhang, Colin J.D. Ross
Publikováno v:
Molecular Therapy. 31:1159-1166
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0352ab3dd2123eb7ea046ef0234a675
https://doi.org/10.1016/j.ymthe.2023.02.009
https://doi.org/10.1016/j.ymthe.2023.02.009
Autor:
Si-Yue, Yu, Alexandra, Birkenshaw, Tyler, Thomson, Tiffany, Carlaw, Lin-Hua, Zhang, Colin J D, Ross
Publikováno v:
The CRISPR Journal. 5:187-202
Genome editing provides a new therapeutic strategy to cure genetic diseases. The recently developed CRISPR-Cas9 base editing technology has shown great potential to repair the majority of pathogenic point mutations in the patient's DNA precisely. Bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2dbc926d8bf1a18a8eada8b6c75ee8
https://doi.org/10.1089/crispr.2021.0109
https://doi.org/10.1089/crispr.2021.0109
Publikováno v:
Human Gene Therapy. 31:794-807
Recent advances in genome sequencing have greatly improved our ability to understand and identify the causes of genetic diseases. However, there remains an urgent need for innovative, safe, and effective treatments for these diseases. CRISPR-based ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699654488e8dc0ba43f1d4c032934cac
https://doi.org/10.1089/hum.2020.111
https://doi.org/10.1089/hum.2020.111
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 5, Pp 941-950 (2012)
The lipidation of apoA-I in liver greatly influences HDL biogenesis and plasma HDL levels by stabilizing the secreted apoA-I. Niacin is the most effective lipid-regulating agent clinically available to raise HDL. This study was undertaken to identify
Externí odkaz:
https://doaj.org/article/93e8fb8fc5c34ba38680dc2a67097473
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 8, Pp 2211-2222 (2010)
Pioglitazone, a hypoglycemic agent, has been shown to increase plasma HDL cholesterol, but the mechanism is incompletely understood. We further investigated effects of pioglitazone on transcriptional regulation of apolipoprotein (apo)A-I gene and fun
Externí odkaz:
https://doaj.org/article/2e1a662a4fc24e7c90b3b353e4a079fd
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 6, Pp 1195-1201 (2008)
Niacin is an effective agent for raising HDL, but its cellular target sites are largely unknown. We examined effects of niacin on the surface expression of ATP synthase β chain, a newly described HDL/apolipoprotein A-I (apoA-I) receptor for HDL endo
Externí odkaz:
https://doaj.org/article/03da20afc7c34848a97763e00288b5bd
Autor:
Cheryl L. Wellington, Yu-Zhou Yang, Stephen Zhou, Susanne M. Clee, Bing Tan, Kenichi Hirano, Karin Zwarts, Anita Kwok, Allison Gelfer, Michel Marcil, Scott Newman, Kirsten Roomp, Roshni Singaraja, Jennifer Collins, Lin-Hua Zhang, Albert K. Groen, Kees Hovingh, Alison Brownlie, Sherrie Tafuri, Jacques Genest, Jr., John J.P. Kastelein, Michael R. Hayden
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 11, Pp 1939-1949 (2002)
Mutations in ABCA1 uniformly decrease plasma HDL-cholesterol (HDL-C) and reduce cholesterol efflux, yet different mutations in ABCA1 result in different phenotypic effects in heterozygotes. For example, truncation mutations result in significantly lo
Externí odkaz:
https://doaj.org/article/a28f9b5721114433ab9269392ebf98fd
Autor:
Alan D. Attie, Yannick Hamon, Angela R. Brooks-Wilson, Mark P. Gray-Keller, Marcia L.E. MacDonald, Veronique Rigot, Angie Tebon, Lin-Hua Zhang, Jacob D. Mulligan, Roshni R. Singaraja, J.James Bitgood, Mark E. Cook, John J.P. Kastelein, Giovanna Chimini, Michael R. Hayden
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 10, Pp 1610-1617 (2002)
The Wisconsin hypoalpha mutant (WHAM) chicken has a >90% reduction in plasma HDL due to hypercatabolism by the kidney of lipid-poor apoA-I. The WHAM chickens have a recessive white skin phenotype caused by a single-gene mutation that maps to the chic
Externí odkaz:
https://doaj.org/article/cf7ebaa088c742f99091cc5643fa3af9
Publikováno v:
Water environment research : a research publication of the Water Environment FederationREFERENCES. 93(9)
This study investigated the relationship between acyl homoserine lactones (AHLs)-based quorum sensing (QS) and the properties of Anammox granular sludge at low temperatures (11-23°C). Results indicated that adding different concentrations of AHLs in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758319b6c8b773cbb77e1990d94c4b69
https://pubmed.ncbi.nlm.nih.gov/33595115
https://pubmed.ncbi.nlm.nih.gov/33595115
Autor:
Lin-Hua Zhang, Howard E. Henderson
Publikováno v:
BioTechniques, Vol 25, Iss 5, Pp 784-788 (1998)
Externí odkaz:
https://doaj.org/article/c0a93ffa965c478fad8cea4de6545504