A phase 1 trial to determine the maximum tolerated dose and patient-specific dosimetry of [¹⁷⁷Lu]Lu-LNC1003 in patients with metastatic castration-resistant prostate cancer.

Autor: Zang, Jie, Wang, Guochang, Zhao, Tianzhi, Liu, Huipan, Lin, Xiuting, Yang, Yun, Shao, Zezhong, Wang, Chao, Chen, Haojun, Chen, Yue, Zhu, Zhaohui, Miao, Weibing, Chen, Xiaoyuan, Zhang, Jingjing

Publikováno v: European Journal of Nuclear Medicine & Molecular Imaging; Feb2024, Vol. 51 Issue 3, p871-882, 12p

A phase 1 trial to determine the maximum tolerated dose and patient-specific dosimetry of [ ¹⁷⁷ Lu]Lu-LNC1003 in patients with metastatic castration-resistant prostate cancer.

Autor: Zang J; Department of Nuclear Medicine, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian Province, China.; Department of Nuclear Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, Fujian Province, China., Wang G; Department of Nuclear Medicine, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian Province, China.; Department of Nuclear Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, Fujian Province, China.; Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100730, China., Zhao T; Departments of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore.; Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore.; Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore., Liu H; Department of Nuclear Medicine, the Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan Province, China.; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Sichuan Province, Luzhou, 646000, China.; Institute of Nuclear Medicine, Southwest Medical University, Luzhou, 646000, Sichuan Province, China.; Academician (Expert) Workstation of Sichuan Province, Luzhou, 646000, Sichuan Province, China., Lin X; Department of Nuclear Medicine, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian Province, China.; Department of Nuclear Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, Fujian Province, China., Yang Y; Department of Nuclear Medicine, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian Province, China.; Department of Nuclear Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, Fujian Province, China., Shao Z; Department of Nuclear Medicine, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian Province, China.; Department of Nuclear Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, Fujian Province, China., Wang C; Department of Nuclear Medicine, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian Province, China.; Department of Nuclear Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, Fujian Province, China., Chen H; Department of Nuclear Medicine and Minnan PET Center, Xiamen Cancer Center, First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361003, China., Chen Y; Department of Nuclear Medicine, the Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan Province, China.; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Sichuan Province, Luzhou, 646000, China.; Institute of Nuclear Medicine, Southwest Medical University, Luzhou, 646000, Sichuan Province, China.; Academician (Expert) Workstation of Sichuan Province, Luzhou, 646000, Sichuan Province, China., Zhu Z; Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100730, China. 13611093752@163.com., Miao W; Department of Nuclear Medicine, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian Province, China. miaoweibing@126.com.; Department of Nuclear Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, Fujian Province, China. miaoweibing@126.com.; Fujian Key Laboratory of Precision Medicine for Cancer, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian Province, China. miaoweibing@126.com., Chen X; Departments of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore. chen.shawn@nus.edu.sg.; Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore. chen.shawn@nus.edu.sg.; Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore. chen.shawn@nus.edu.sg.; Departments of Surgery, Chemical and Biomolecular Engineering, College of Design and Engineering, National University of Singapore, Singapore, 117597, Singapore. chen.shawn@nus.edu.sg.; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, 117597, Singapore. chen.shawn@nus.edu.sg.; Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), 61 Biopolis Drive, Proteos, 138673, Singapore, Singapore. chen.shawn@nus.edu.sg., Zhang J; Departments of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore. j.zhang@nus.edu.sg.; Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore. j.zhang@nus.edu.sg.; Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore. j.zhang@nus.edu.sg.

Publikováno v: European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2024 Feb; Vol. 51 (3), pp. 871-882. Date of Electronic Publication: 2023 Oct 21.