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Refining antipsychotic treatment strategies in schizophrenia: discovery of genetic biomarkers for enhanced drug response prediction.

Autor: Chen L; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China., Huai C; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China., Song C; The Fourth People's Hospital of Wuhu, Wuhu, China., Wu S; The Second People's Hospital of Lishui, Lishui, China., Xu Y; Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, China.; Department of Clinical Psychology, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen City, Guangdong Province, China., Yi Z; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Tang J; Department of Psychiatry, Sir Run-Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China., Fan L; The Affiliated Encephalopathy Hospital of Zhengzhou University, Zhumadian Second People's Hospital, Zhumadian, China., Wu X; Jiangsu Nantong Fourth People's Hospital, Nantong, Jiangsu Province, China., Ge Z; Jiangsu Nantong Fourth People's Hospital, Nantong, Jiangsu Province, China., Liu C; Department of Psychiatry, Jining Medical University School of Mental Health, Jining, China., Jiang D; Wenzhou Seventh People's Hospital, Wenzhou, China., Weng S; Fuzhou Neuro-psychiatric Hospital Affiliated to Fujian Medical University, Fuzhou, China., Wang G; Wuxi Mental Health Center Affiliated to Nanjing Medical University, Wuxi, China., Zhang X; Jingzhou Mental Health Center, Jingzhou, China., Zhao X; Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai, China., Shen L; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.; Institutes of Biomedical Sciences, Fudan University, Shanghai, China., Zhang N; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.; Shanghai Jiao Tong University Sichuan Research Institute (SJTUSRI), Chengdu, Sichuan Province, China., Wu H; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China., Wang Y; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China., Guo Z; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zhang S; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China., Jiang B; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China., Zhou W; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.; Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health & Department of Developmental and Behavioural Paediatric & Child Primary Care, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China., Ma J; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China., Li M; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China., Chu Y; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China., Zhou C; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China., Lv Q; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Xu Q; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhu W; The Fourth People's Hospital of Wuhu, Wuhu, China., Zhang Y; The Second People's Hospital of Lishui, Lishui, China., Lian W; The Second People's Hospital of Lishui, Lishui, China., Liu S; Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, China., Li X; Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, China., Gao S; The Affiliated Encephalopathy Hospital of Zhengzhou University, Zhumadian Second People's Hospital, Zhumadian, China., Liu A; The Affiliated Encephalopathy Hospital of Zhengzhou University, Zhumadian Second People's Hospital, Zhumadian, China., He L; The Affiliated Encephalopathy Hospital of Zhengzhou University, Zhumadian Second People's Hospital, Zhumadian, China., Yang Z; Department of Psychiatry, Jining Medical University School of Mental Health, Jining, China., Dai B; Wenzhou Seventh People's Hospital, Wenzhou, China., Ye J; Wenzhou Seventh People's Hospital, Wenzhou, China., Lin R; Fuzhou Neuro-psychiatric Hospital Affiliated to Fujian Medical University, Fuzhou, China., Lu Y; Wuxi Mental Health Center Affiliated to Nanjing Medical University, Wuxi, China., Yan Q; Jiangsu Nantong Fourth People's Hospital, Nantong, Jiangsu Province, China., Hu Y; Jiangsu Nantong Fourth People's Hospital, Nantong, Jiangsu Province, China., Xing Q; Children's Hospital of Fudan University and Institutes of Biomedical Sciences of Fudan University, Shanghai, China., Huang H; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. hhuang@broadinstitute.org.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. hhuang@broadinstitute.org.; Department of Medicine, Harvard Medical School, Boston, MA, USA. hhuang@broadinstitute.org., Qin S; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China. chinsir@sjtu.edu.cn.; Shanghai Jiao Tong University Sichuan Research Institute (SJTUSRI), Chengdu, Sichuan Province, China. chinsir@sjtu.edu.cn.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2024 Nov 19. Date of Electronic Publication: 2024 Nov 19.