Immunogenicity and efficacy of the COVID-19 candidate vector vaccine MVA-SARS-2-S in preclinical vaccination

Autor: Tscherne, Alina, Schwarz, Jan Hendrik, Rohde, Cornelius, Kupke, Alexandra, Kalodimou, Georgia, Limpinsel, Leonard, Okba, Nisreen M. A., Bošnjak, Berislav, Sandrock, Inga, Odak, Ivan, Halwe, Sandro, Sauerhering, Lucie, Brosinski, Katrin, Liangliang, Nan, Duell, Elke, Jany, Sylvia, Freudenstein, Astrid, Schmidt, Jörg, Werner, Anke, Serra, Michelle Gellhorn, Klüver, Michael, Guggemos, Wolfgang, Seilmaier, Michael, Wendtner, Clemens-Martin, Förster, Reinhold, Haagmans, Bart L., Becker, Stephan, Sutter, Gerd, Volz, Asisa

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2021 Jul . 118(28), 1-9.

Externí odkaz: https://www.jstor.org/stable/27052465

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Stabilized recombinant SARS-CoV-2 spike antigen enhances vaccine immunogenicity and protective capacity.

Autor: Meyer Zu Natrup C; Institute of Virology, University of Veterinary Medicine Hannover, Foundation, Hanover, Germany., Tscherne A; Division of Virology, Department of Veterinary Sciences, LMU Munich, Munich, Germany.; German Center for Infection Research, partner site Munich, and., Dahlke C; partner site Hamburg-Lübeck-Borstel-Riems.; University Medical Center Hamburg-Eppendorf, Institute for Infection Research and Vaccine Development (IIRVD), Hamburg, Germany., Ciurkiewicz M; Department of Pathology, University of Veterinary Medicine Hannover, Foundation, Hanover, Germany., Shin DL; Institute of Virology, University of Veterinary Medicine Hannover, Foundation, Hanover, Germany., Fathi A; partner site Hamburg-Lübeck-Borstel-Riems.; University Medical Center Hamburg-Eppendorf, Institute for Infection Research and Vaccine Development (IIRVD), Hamburg, Germany.; University Medical Center Hamburg-Eppendorf, Division of Infectious Diseases, Hamburg, Germany., Rohde C; German Center for Infection Research, partner site Gießen-Marburg-Langen.; Institute of Virology, Philipps University Marburg, Marburg, Germany., Kalodimou G; Division of Virology, Department of Veterinary Sciences, LMU Munich, Munich, Germany.; German Center for Infection Research, partner site Munich, and., Halwe S; Institute of Virology, Philipps University Marburg, Marburg, Germany., Limpinsel L; Division of Virology, Department of Veterinary Sciences, LMU Munich, Munich, Germany., Schwarz JH; Division of Virology, Department of Veterinary Sciences, LMU Munich, Munich, Germany., Klug M; German Center for Infection Research, partner site Tübingen.; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany., Esen M; German Center for Infection Research, partner site Tübingen.; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany., Schneiderhan-Marra N; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany., Dulovic A; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany., Kupke A; German Center for Infection Research, partner site Gießen-Marburg-Langen.; Institute of Virology, Philipps University Marburg, Marburg, Germany., Brosinski K; Division of Virology, Department of Veterinary Sciences, LMU Munich, Munich, Germany., Clever S; Institute of Virology, University of Veterinary Medicine Hannover, Foundation, Hanover, Germany., Schünemann LM; Institute of Virology, University of Veterinary Medicine Hannover, Foundation, Hanover, Germany., Beythien G; Department of Pathology, University of Veterinary Medicine Hannover, Foundation, Hanover, Germany., Armando F; Department of Pathology, University of Veterinary Medicine Hannover, Foundation, Hanover, Germany., Mayer L; partner site Hamburg-Lübeck-Borstel-Riems.; University Medical Center Hamburg-Eppendorf, Institute for Infection Research and Vaccine Development (IIRVD), Hamburg, Germany.; University Medical Center Hamburg-Eppendorf, Division of Infectious Diseases, Hamburg, Germany., Weskamm ML; partner site Hamburg-Lübeck-Borstel-Riems.; University Medical Center Hamburg-Eppendorf, Institute for Infection Research and Vaccine Development (IIRVD), Hamburg, Germany.; University Medical Center Hamburg-Eppendorf, Division of Infectious Diseases, Hamburg, Germany., Jany S; Division of Virology, Department of Veterinary Sciences, LMU Munich, Munich, Germany., Freudenstein A; Division of Virology, Department of Veterinary Sciences, LMU Munich, Munich, Germany., Tuchel T; Institute of Virology, University of Veterinary Medicine Hannover, Foundation, Hanover, Germany., Baumgärtner W; Department of Pathology, University of Veterinary Medicine Hannover, Foundation, Hanover, Germany., Kremsner P; German Center for Infection Research, partner site Tübingen.; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.; Centre de Recherches Médicales de Lambarene, Gabon., Fendel R; German Center for Infection Research, partner site Tübingen.; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany., Addo MM; University Medical Center Hamburg-Eppendorf, Institute for Infection Research and Vaccine Development (IIRVD), Hamburg, Germany.; German Center for Infection Research, partner site Tübingen., Becker S; German Center for Infection Research, partner site Gießen-Marburg-Langen.; Institute of Virology, Philipps University Marburg, Marburg, Germany., Sutter G; Division of Virology, Department of Veterinary Sciences, LMU Munich, Munich, Germany.; German Center for Infection Research, partner site Munich, and., Volz A; Institute of Virology, University of Veterinary Medicine Hannover, Foundation, Hanover, Germany.; German Center for Infection Research, partner site Hanover-Braunschweig.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2022 Dec 15; Vol. 132 (24). Date of Electronic Publication: 2022 Dec 15.