Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Limor Cohen"'
Autor:
Xin Peng, Xin Huang, Talal Ben Lulu, Wenqing Jia, Shaolu Zhang, Limor Cohen, Shengfan Huang, Jindian Fan, Xi Chen, Shanshan Liu, Yongzhe Wang, Kailin Wang, Sho Isoyama, Shingo Dan, Feng Wang, Zhe Zhang, Moshe Elkabets, Dexin Kong
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-23 (2024)
Abstract Background Phosphoinositide 3-kinases (PI3Ks) are critical regulators of diverse cellular functions and have emerged as promising targets in cancer therapy. Despite significant progress, existing PI3K inhibitors encounter various challenges
Externí odkaz:
https://doaj.org/article/8ff42a862e624392b12fa5dce4b9e982
Autor:
Girija Goyal, Pranav Prabhala, Gautam Mahajan, Bruce Bausk, Tal Gilboa, Liangxia Xie, Yunhao Zhai, Roey Lazarovits, Adam Mansour, Min Sun Kim, Aditya Patil, Danielle Curran, Jaclyn M. Long, Sanjay Sharma, Abidemi Junaid, Limor Cohen, Thomas C. Ferrante, Oren Levy, Rachelle Prantil‐Baun, David R. Walt, Donald E. Ingber
Publikováno v:
Advanced Science, Vol 9, Iss 14, Pp n/a-n/a (2022)
Abstract Lymphoid follicles (LFs) are responsible for generation of adaptive immune responses in secondary lymphoid organs and form ectopically during chronic inflammation. A human model of ectopic LF formation will provide a tool to understand LF de
Externí odkaz:
https://doaj.org/article/72989818cd824b03a101649325a3d3a1
Autor:
Barak Rotblat, Andreas Mock, Jerome Fayette, Limor Cohen, Idan Cohen, Elena Voronov, Jebrane Bouaoud, Lucas Michon, Pierre Saintigny, Luc G T Morris, Manu Prasad, Jonathan Zorea, Sankar Jagadeeshan, Avital B Shnerb, Sooraj Mathukkada, Ofra Novoplansky, Mai Badarni, Ksenia M Yegodayev, Sapir Tzadok, Libor Brezina, Andy Karabajakian, Tomer Cooks, Irit Allon, Orr Dimitstein, Benzion Joshua, Dexin Kong, Maurizio Scaltriti, Yaron Carmi, Cristina Conde-Lopez, Jochen Hess, Ina Kurth, Moshe Elkabets
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Although the mitogen-activated protein kinases (MAPK) pathway is hyperactive in head and neck cancer (HNC), inhibition of MEK1/2 in HNC patients has not shown clinically meaningful activity. Therefore, we aimed to characterize the effect o
Externí odkaz:
https://doaj.org/article/e52b0f83da384bc987314eeb1cc6f2e4
Autor:
Alissa Keegan, Padric Garden, Limor Cohen, Reiko Nishihara, Anika Adeni, Cloud Paweletz, Julianna Supplee, Pasi A Jänne, Mark M Awad, David R Walt
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Blood-based biomarkers of anti-solid tumor immune checkpoint blockade (ICB) response are lacking. We hypothesized that changes in systemic cytokine levels with the initial doses of programmed cell death protein 1 (PD-1) pathway inhibitors
Externí odkaz:
https://doaj.org/article/97ad95d9e28e4f6882c60ec31ab1624e
Autor:
Mai Badarni, Manu Prasad, Artemiy Golden, Baisali Bhattacharya, Liron Levin, Ksenia M. Yegodayev, Orr Dimitstein, Ben-Zion Joshua, Limor Cohen, Ekaterina Khrameeva, Dexin Kong, Angel Porgador, Alex Braiman, Jennifer R. Grandis, Barak Rotblat, Moshe Elkabets
Publikováno v:
Cancers, Vol 13, Iss 9, p 2250 (2021)
Over 50% of human papilloma positive head-and-neck cancer (HNCHPV+) patients harbor genomic-alterations in PIK3CA, leading to hyperactivation of the phosphatidylinositol-4, 5-bisphosphate 3-kinase (PI3K) pathway. Nevertheless, despite PI3K pathway ac
Externí odkaz:
https://doaj.org/article/d3a45bca557f421fbdc5d20ebbc8c3da
Autor:
Susmita Ghosh, Manu Prasad, Kiran Kundu, Limor Cohen, Ksenia M. Yegodayev, Jonathan Zorea, Ben-Zion Joshua, Batel Lasry, Orr Dimitstein, Anat Bahat-Dinur, Aviram Mizrachi, Vladimir Lazar, Moshe Elkabets, Angel Porgador
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Despite of remarkable progress made in the head and neck cancer (HNC) therapy, the survival rate of this metastatic disease remain low. Tailoring the appropriate therapy to patients is a major challenge and highlights the unmet need to have a good pr
Externí odkaz:
https://doaj.org/article/d2d5310777864ed694a8064ed507fa5f
Autor:
Ksenia M. Yegodayev, Ofra Novoplansky, Artemiy Golden, Manu Prasad, Liron Levin, Sankar Jagadeeshan, Jonathan Zorea, Orr Dimitstein, Ben-Zion Joshua, Limor Cohen, Ekaterina Khrameeva, Moshe Elkabets
Publikováno v:
Cancers, Vol 12, Iss 2, p 339 (2020)
Most head and neck cancer (HNC) patients are resistant to cetuximab, an antibody against the epidermal growth factor receptor. Such therapy resistance is known to be mediated, in part, by stromal cells surrounding the tumor cells; however, the mechan
Externí odkaz:
https://doaj.org/article/cd49b47db7834c8fa6eddce0e2065b9b
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35482 (2012)
Zinc enhances epithelial proliferation, protects the digestive epithelial layer and has profound antiulcerative and antidiarrheal roles in the colon. Despite the clinical significance of this ion, the mechanisms linking zinc to these cellular process
Externí odkaz:
https://doaj.org/article/59a30b57e2ad4fc69128f43b04e420aa
Autor:
David T. Ting, Benjamin D. Greenbaum, Peter J. Park, Kathleen H. Burns, David R. Walt, Shelley L. Berger, Theodore S. Hong, Martin J. Aryee, Miguel N. Rivera, Vikram Deshpande, Ryan B. Corcoran, David P. Ryan, Jennifer Y. Wo, Lipika Goyal, Jeffrey W. Clark, Lawrence S. Blaszkowsky, Jill N. Allen, Hui Zheng, Yasmeen Senussi, Padric M. Garden, Limor Cohen, Vishal Thapar, Matteo Ligorio, Kshitij S. Arora, Niyati Desai, Linda T. Nieman, Michael J. Raabe, Jasmin Joseph-Chazan, Chenyue Lu, Eric C. Tai, Kevin D. Vo, Emily E. Van Seventer, Richard Y. Ebright, Nova Xu, Antuan V. Tran, Stefanie Gerstberger, Annamaria Szabolcs, Charly R. Good, Katherine A. Alexander, Connie Wu, Martin S. Taylor, Christopher Jaicks, Katherine H. Xu, Chong Chu, Anupriya S. Kulkarni, Eunae You, Alexander Solovyov, Aparna R. Parikh, Mihir Rajurkar
Altered RNA expression of repetitive sequences and retrotransposition are frequently seen in colorectal cancer, implicating a functional importance of repeat activity in cancer progression. We show the nucleoside reverse transcriptase inhibitor 3TC t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872fbbb37783ee4cbd8e559e5d98142a
https://doi.org/10.1158/2159-8290.c.6549619.v1
https://doi.org/10.1158/2159-8290.c.6549619.v1
Autor:
David T. Ting, Benjamin D. Greenbaum, Peter J. Park, Kathleen H. Burns, David R. Walt, Shelley L. Berger, Theodore S. Hong, Martin J. Aryee, Miguel N. Rivera, Vikram Deshpande, Ryan B. Corcoran, David P. Ryan, Jennifer Y. Wo, Lipika Goyal, Jeffrey W. Clark, Lawrence S. Blaszkowsky, Jill N. Allen, Hui Zheng, Yasmeen Senussi, Padric M. Garden, Limor Cohen, Vishal Thapar, Matteo Ligorio, Kshitij S. Arora, Niyati Desai, Linda T. Nieman, Michael J. Raabe, Jasmin Joseph-Chazan, Chenyue Lu, Eric C. Tai, Kevin D. Vo, Emily E. Van Seventer, Richard Y. Ebright, Nova Xu, Antuan V. Tran, Stefanie Gerstberger, Annamaria Szabolcs, Charly R. Good, Katherine A. Alexander, Connie Wu, Martin S. Taylor, Christopher Jaicks, Katherine H. Xu, Chong Chu, Anupriya S. Kulkarni, Eunae You, Alexander Solovyov, Aparna R. Parikh, Mihir Rajurkar
Supplementary Figure from Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba166183bd8c52fab4bd2fa1beca42eb
https://doi.org/10.1158/2159-8290.22541353.v1
https://doi.org/10.1158/2159-8290.22541353.v1